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Fourth universal definition of myocardial infarction (2018)

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Thygesen, Kristian, Alpert, Joseph S, Jaffe, Allan S, Chaitman, Bernard R, Bax, Jeroen J, Morrow, David A, White, Harvey D, ESC Scientific Document Group, Thygesen, Kristian, Alpert, Joseph S, Jaffe, Allan S, Chaitman, Bernard R, Bax, Jeroen J, Morrow, David A, White, Harvey D, Mickley, Hans, Crea, Filippo, Van de Werf, Frans, Bucciarelli-Ducci, Chiara, Katus, Hugo A, Pinto, Fausto J, Antman, Elliott M, Hamm, Christian W, De Caterina, Raffaele, Januzzi, James L, Apple, Fred S, Alonso Garcia, Maria Angeles, Underwood, S Richard, Canty, John M, Lyon, Alexander R, Devereaux, P J, Zamorano, Jose Luis, Lindahl, Bertil, Weintraub, William S, Newby, L Kristin, Virmani, Renu, Vranckx, Pascal, Cutlip, Don, Gibbons, Raymond J, Smith, Sidney C, Atar, Dan, Luepker, Russell V, Robertson, Rose Marie, Bonow, Robert O, Steg, P Gabriel, O’Gara, Patrick T, Fox, Keith A A, Hasdai, David, Aboyans, Victor, Achenbach, Stephan, Agewall, Stefan, Alexander, Thomas, Avezum, Alvaro, Barbato, Emanuele, Bassand, Jean-Pierre, Bates, Eric, Bittl, John A, Breithardt, Güenter, Bueno, Héctor, Bugiardini, Raffaele, Cohen, Mauricio G, Dangas, George, de Lemos, James A, Delgado, Victoria, Filippatos, Gerasimos, Fry, Edward, Granger, Christopher B, Halvorsen, Sigrun, Hlatky, Mark A, Ibanez, Borja, James, Stefan, Kastrati, Adnan, Leclercq, Christophe, Mahaffey, Kenneth W, Mehta, Laxmi, Müller, Christian, Patrono, Carlo, Piepoli, Massimo Francesco, Piñeiro, Daniel, Roffi, Marco, Rubboli, Andrea, Sharma, Samin, Simpson, Iain A, Tendera, Michael, Valgimigli, Marco, van der Wal, Allard C, Windecker, Stephan, Chettibi, Mohamed, Hayrapetyan, Hamlet, Roithinger, Franz Xaver, Aliyev, Farid, Sujayeva, Volha, Claeys, Marc J, Smajić, Elnur, Kala, Petr, Iversen, Kasper Karmak, El Hefny, Ehab, Marandi, Toomas, Porela, Pekka, Antov, Slobodan, Gilard, Martine, Blankenberg, Stefan, Davlouros, Periklis, Gudnason, Thorarinn, Alcalai, Ronny, Colivicchi, Furio, Elezi, Shpend, Baitova, Gulmira, Zakke, Ilja, Gustiene, Olivija, Beissel, Jean, Dingli, Philip, Grosu, Aurel, Damman, Peter, Juliebø, Vibeke, Legutko, Jacek, Morais, Joäo, Tatu-Chitoiu, Gabriel, Yakovlev, Alexey, Zavatta, Marco, Nedeljkovic, Milan, Radsel, Peter, Sionis, Alessandro, Jemberg, Tomas, Müller, Christian, Abid, Leila, Abaci, Adnan, Parkhomenko, Alexandr, Corbett, Simon·2019·European Heart Journal
DOI 10.1093/eurheartj/ehy462
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Abstract

... ... ... ... In the late 19th century, post-mortem examinations demonstrated a possible relationship between thrombotic occlusion of a coronary artery and myocardial infarction (MI).1 However, it was not until the beginning of the 20th century that the first clinical descriptions appeared describing a connection between the formation of a thrombus in a coronary artery and its associated clinical features.2 , 3 Despite these landmark observations, considerable time elapsed before general clinical acceptance of this entity was achieved, in part due to one autopsy study that showed no thrombi in the coronary arteries of 31% of deceased patients with an MI.4 The clinical entity was referred to as coronary thrombosis, although use of the term ‘MI’ ultimately prevailed. Over the years, several different definitions of MI have been used, leading to controversy and confusion. Hence, a general and worldwide definition for MI was needed. This occurred for the first time in the 1950–70s, when working groups from the World Health Organization (WHO) established a primarily electrocardiographic (ECG)-based definition of MI intended for epidemiological use.5 The original description, with minor modifications, is still used in epidemiological surveys (Figure 1).6–8

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Metadata

Authors
Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., ESC Scientific Document Group, Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., Mickley, H., Crea, F., Van de Werf, F., Bucciarelli-Ducci, C., Katus, H. A., Pinto, F. J., Antman, E. M., Hamm, C. W., De Caterina, R., Januzzi, J. L., Apple, F. S., Alonso Garcia, M. A., Underwood, S. R., Canty, J. M., Lyon, A. R., Devereaux, P. J., Zamorano, J. L., Lindahl, B., Weintraub, W. S., Newby, L. K., Virmani, R., Vranckx, P., Cutlip, D., Gibbons, R. J., Smith, S. C., Atar, D., Luepker, R. V., Robertson, R. M., Bonow, R. O., Steg, P. G., O’Gara, P. T., Fox, K. A. A., Hasdai, D., Aboyans, V., Achenbach, S., Agewall, S., Alexander, T., Avezum, A., Barbato, E., Bassand, J.-P., Bates, E., Bittl, J. A., Breithardt, G., Bueno, H., Bugiardini, R., Cohen, M. G., Dangas, G., de Lemos, J. A., Delgado, V., Filippatos, G., Fry, E., Granger, C. B., Halvorsen, S., Hlatky, M. A., Ibanez, B., James, S., Kastrati, A., Leclercq, C., Mahaffey, K. W., Mehta, L., Müller, C., Patrono, C., Piepoli, M. F., Piñeiro, D., Roffi, M., Rubboli, A., Sharma, S., Simpson, I. A., Tendera, M., Valgimigli, M., van der Wal, A. C., Windecker, S., Chettibi, M., Hayrapetyan, H., Roithinger, F. X., Aliyev, F., Sujayeva, V., Claeys, M. J., Smajić, E., Kala, P., Iversen, K. K., El Hefny, E., Marandi, T., Porela, P., Antov, S., Gilard, M., Blankenberg, S., Davlouros, P., Gudnason, T., Alcalai, R., Colivicchi, F., Elezi, S., Baitova, G., Zakke, I., Gustiene, O., Beissel, J., Dingli, P., Grosu, A., Damman, P., Juliebø, V., Legutko, J., Morais, J., Tatu-Chitoiu, G., Yakovlev, A., Zavatta, M., Nedeljkovic, M., Radsel, P., Sionis, A., Jemberg, T., Müller, C., Abid, L., Abaci, A., Parkhomenko, A., & Corbett, S.
Venue
European Heart Journal
Publisher
Oxford University Press (OUP)
Published
2018-08-25
Volume
40
Issue
3
Pages
237-269
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
DOI
10.1093/eurheartj/ehy462
OpenAlex
W2888543854
Cited by
5,880
References
8
FWCI
428.89
Type
journal article
Language
en
Open access
bronze
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)

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CoChat. (2026). Citation check: Fourth universal definition of myocardial infarction (2018). https://app.cochat.ai/papers/10.1093/eurheartj/ehy462
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Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., ESC Scientific Document Group, Thygesen, K., Alpert, J. S., Jaffe, A. S., Chaitman, B. R., Bax, J. J., Morrow, D. A., White, H. D., Mickley, H., Crea, F., Van de Werf, F., Bucciarelli-Ducci, C., . . . Corbett, S. (2019). Fourth universal definition of myocardial infarction (2018). European Heart Journal. https://doi.org/10.1093/eurheartj/ehy462

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