The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Pathological Evidence for SARS-CoV-2 as a Cause of Myocarditis
Open accessAbstract
To investigate whether severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)–induced myocarditis constitutes an important mechanism of cardiac injury, a review was conducted of the published data and the authors’ experience was added from autopsy examination of 16 patients dying of SARS-CoV-2 infection. Myocarditis is an uncommon pathologic diagnosis occurring in 4.5% of highly selected cases undergoing autopsy or endomyocardial biopsy. Although polymerase chain reaction–detectable virus could be found in the lungs of most coronavirus disease-2019 (COVID-19)–infected subjects in our own autopsy registry, in only 2 cases was the virus detected in the heart. It should be appreciated that myocardial inflammation alone by macrophages and T cells can be seen in noninfectious deaths and COVID-19 cases, but the extent of each is different, and in neither case do such findings represent clinically relevant myocarditis. Given its extremely low frequency and unclear therapeutic implications, the authors do not advocate use of endomyocardial biopsy to diagnose myocarditis in the setting of COVID-19.
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Cites
Pathological findings of COVID-19 associated with acute respiratory distress syndrome
Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Liu, S., Zhao, P., Liu, H., Zhu, L., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30076-x · Cited by 8,545
Endothelial cell infection and endotheliitis in COVID-19
Varga, Z., Flammer, A. J., Steiger, P., Haberecker, M., Andermatt, R., Zinkernagel, A. S., Mehra, M. R., Schuepbach, R. A., Ruschitzka, F., & Moch, H. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30937-5 · Cited by 6,358
Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China
Shi, S., Qin, M., Shen, B., Cai, Y., Liu, T., Yang, F., Gong, W., Liu, X., Liang, J., Zhao, Q., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.0950 · Cited by 4,349
Chen, L., Li, X., Chen, M., Feng, Y., & Xiong, C. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa078 · Cited by 1,163 · cited 1×
“In addition to the possibility of false-negative PCR results during tissue sampling, it is also likely that given the low overall expression of ACE2 receptor in myocardial cells, tropism of SARS CoV-2 for the heart is not likely (32).”
BackgroundCytokine Storm in COVID-19: The Current Evidence and Treatment Strategies
Tang, Y., Liu, J., Zhang, D., Xu, Z., Ji, J., & Wen, C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01708 · Cited by 1,094
Myocarditis: The Dallas criteria
Thomas Aretz, H. (1987) · Human Pathology · doi:10.1016/s0046-8177(87)80363-5 · Cited by 809
Cited by
Symptomatic Acute Myocarditis in 7 Adolescents After Pfizer-BioNTech COVID-19 Vaccination
Marshall, M., Ferguson, I. D., Lewis, P., Jaggi, P., Gagliardo, C., Collins, J. S., Shaughnessy, R., Caron, R., Fuss, C., Corbin, K. J. E., et al. (2021) · Pediatrics · doi:10.1542/peds.2021-052478 · Cited by 367
Blagova, O. V., Kogan, E. A., Lutokhina, Y. A., Kukleva, A. D., Ainetdinova, D. H., Novosadov, V. M., Rud`, R. S., Zaitsev, A. Y., Zaidenov, V. A., Kupriyanova, A. G., et al. (2021) · Kardiologiia · doi:10.18087/cardio.2021.6.n1659 · Cited by 34
Myocarditis mortality with and without COVID-19: insights from a national registry
Bemtgen, X., Kaier, K., Rilinger, J., Rottmann, F., Supady, A., von zur Mühlen, C., Westermann, D., Wengenmayer, T., & Staudacher, D. L. (2024) · Clinical Research in Cardiology · doi:10.1007/s00392-022-02141-9 · Cited by 23
Metadata
- Authors
- Kawakami, R., Sakamoto, A., Kawai, K., Gianatti, A., Pellegrini, D., Nasr, A., Kutys, B., Guo, L., Cornelissen, A., Mori, M., Sato, Y., Pescetelli, I., Brivio, M., Romero, M., Guagliumi, G., Virmani, R., & Finn, A. V.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 77
- Issue
- 3
- Pages
- 314-325
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W3123993889
- Cited by
- 233
- References
- 6
- FWCI
- 32.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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