Long-Haul Post–COVID-19 Symptoms Presenting as a Variant of Postural Orthostatic Tachycardia Syndrome
Open accessAbstract
Major clinical centers in Sweden have witnessed an inflow of patients with chronic symptoms following initial outpatient care for coronavirus disease-2019 (COVID-19) infection, suggestive of postural orthostatic tachycardia syndrome. This report presents the first case series of 3 Swedish patients diagnosed with postural orthostatic tachycardia syndrome more than 3 months after the primary COVID-2019 infections. (Level of Difficulty: Intermediate.)
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
POTS may have an immunological cause.
“Postural orthostatic tachycardia syndrome may have an immunological cause.”
From Diagnosis and management of postural orthostatic tachycardia syndrome (2022) · cites this paper as [30]
The Discussion (page unavailable) says a chronic inflammatory or autoimmune response may be involved in post–COVID-19 POTS. That supports an immunological cause as a possibility, but the paper limits this suggestion to post–COVID-19 POTS rather than POTS generally. (LLM, conf=0.83)
Experimental — accuracy not yet measuredMany patients with POTS describe a postviral onset.
“Many patients describe a postviral onset,29–32”
From Diagnosis and management of postural orthostatic tachycardia syndrome (2022) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Postural Orthostatic Tachycardia Syndrome
Bryarly, M., Phillips, L. T., Fu, Q., Vernino, S., & Levine, B. D. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.059 · Cited by 245 · see citing works
Autoimmunity in postural orthostatic tachycardia syndrome: Current understanding
Vernino, S., & Stiles, L. E. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.04.005 · Cited by 107 · cited 1× · see citing works
“The syndrome has been postulated to have post-viral autoimmune activation as a possible etiology (3).”
BackgroundPharmacotherapy for postural tachycardia syndrome
Miller, A. J., & Raj, S. R. (2018) · Autonomic Neuroscience · doi:10.1016/j.autneu.2018.04.008 · Cited by 91 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- [2]Bryarly M. Phillips L.T. Fu Q. Vernino S. Levine B.D. Postural orthostatic tachycardia syndrome: JACC focus seminar J Am Coll Cardiol 73 2019 1207 1228 30871704
- [4]Wiersinga W.J. Rhodes A. Cheng A.C. Peacock S.J. Prescott H.C. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review JAMA 324 2020 782 793 32648899
- [5]Olshansky B. Cannom D. Fedorowski A. Postural orthostatic tachycardia syndrome (POTS): a critical assessment Prog Cardiovasc Dis 63 2020 263 270 32222376 PMC9012474
- [6]Miglis M.G. Prieto T. Shaik R. Muppidi S. Sinn D.I. Jaradeh S. A case report of postural tachycardia syndrome after COVID-19 Clin Auton Res 30 2020 449 451 32880754 PMC7471493
- [7]Kanjwal K. Jamal S. Kichloo A. Grubb B.P. New-onset postural orthostatic tachycardia syndrome following coronavirus disease 2019 infection J Innov Card Rhythm Manag 11 2020 4302 4304 33262898 PMC7685310
- [8]Watson J. Richter A. Deeks J. Testing for SARS-CoV-2 antibodies BMJ 370 2020 m3325 32900692
Cited by
Sorted by citations
Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
Yong, S. J. (2021) · Infectious Diseases · doi:10.1080/23744235.2021.1924397 · Cited by 1,339 · see citing works
Post-COVID-19 Tachycardia Syndrome: A Distinct Phenotype of Post-Acute COVID-19 Syndrome
Ståhlberg, M., Reistam, U., Fedorowski, A., Villacorta, H., Horiuchi, Y., Bax, J., Pitt, B., Matskeplishvili, S., Lüscher, T. F., Weichert, I., et al. (2021) · The American Journal of Medicine · doi:10.1016/j.amjmed.2021.07.004 · Cited by 183 · see citing works
Self-citationNguyen, N. N., Hoang, V. T., Dao, T. L., Dudouet, P., Eldin, C., & Gautret, P. (2022) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-022-04417-4 · Cited by 91 · see citing works
Diagnosis and management of postural orthostatic tachycardia syndrome
Raj, S. R., Fedorowski, A., & Sheldon, R. S. (2022) · Canadian Medical Association Journal · doi:10.1503/cmaj.211373 · Cited by 95 · see citing works
Self-citationSinus Tachycardia: a Multidisciplinary Expert Focused Review
Mayuga, K. A., Fedorowski, A., Ricci, F., Gopinathannair, R., Dukes, J. W., Gibbons, C., Hanna, P., Sorajja, D., Chung, M., Benditt, D., et al. (2022) · Circulation: Arrhythmia and Electrophysiology · doi:10.1161/circep.121.007960 · Cited by 59 · see citing works
Self-citation
- Authors
- Johansson, M., Ståhlberg, M., Runold, M., Nygren-Bonnier, M., Nilsson, J., Olshansky, B., Bruchfeld, J., & Fedorowski, A.
- Affiliations
- Lund University (SE)
- Karolinska University Hospital (SE)
- University of Iowa (US)
- Corresponding author
- Johansson, Madeleine
- ORCID
- Venue
- JACC: Case Reports
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 3
- Issue
- 4
- Pages
- 573-580
- ISSN
- 2666-0849 (ISSN-L)
- PMC
- PMC7946344
- OpenAlex
- W3133623762
- Cited by
- 193
- References
- 3
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 25 · 2023: 44 · 2022: 59 · 2021: 38
- FWCI
- 38.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- JACC Case Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- long COVID, postural orthostatic tachycardia syndrome, COVID-19 pandemic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
