The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Effect of filaggrin breakdown products on growth of and protein expression by Staphylococcus aureus
Open accessAbstract
BACKGROUND: Colonization of the skin by Staphylococcus aureus in individuals with atopic dermatitis exacerbates inflammation. Atopic dermatitis is associated with loss-of-function mutations in the filaggrin (FLG) gene, accompanied by reduced levels of filaggrin breakdown products on the skin. OBJECTIVE: To assess the affect of growth in the presence of the filaggrin breakdown products urocanic acid (UCA) and pyrrolidone carboxylic acid (PCA) on fitness of and protein expression by S aureus. METHODS: S aureus was grown for 24 hours in the presence of UCA and PCA, and the density of the cultures was monitored by recording OD(600) values. Cell wall extracts and secreted proteins of S aureus were isolated and analyzed by SDS-PAGE. Cell wall-associated proteins known to be involved in colonization and immune evasion including clumping factor B, fibronectin binding proteins, protein A, iron-regulated surface determinant A, and the serine-aspartate repeat proteins were examined by Western immunoblotting. RESULTS: Acidification of growth media caused by the presence of UCA and PCA resulted in reduced growth rates and reduced final cell density of S aureus. At the lower pH, reduced expression of secreted and cell wall-associated proteins, including proteins involved in colonization (clumping factor B, fibronectin binding protein A) and immune evasion (protein A), was observed. Decreased expression of iron-regulated surface determinant A due to growth with filaggrin breakdown products appeared to be independent of the decreased pH. CONCLUSION: S aureus grown under mildly acidic conditions such as those observed on healthy skin expresses reduced levels of proteins that are known to be involved in immune evasion.
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Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978
Self-citationThe role of nasal carriage in Staphylococcus aureus infections
Wertheim, H. F., Melles, D. C., Vos, M. C., van Leeuwen, W., van Belkum, A., Verbrugh, H. A., & Nouwen, J. L. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70295-4 · Cited by 2,685
Lina, G., Piemont, Y., Godail-Gamot, F., Bes, M., Peter, M.-O., Gauduchon, V., Vandenesch, F., & Etienne, J. (1999) · Clinical Infectious Diseases · doi:10.1086/313461 · Cited by 2,489
Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1
Gómez, M. I., Lee, A., Reddy, B., Muir, A., Soong, G., Pitt, A., Cheung, A., & Prince, A. (2004) · Nature Medicine · doi:10.1038/nm1079 · Cited by 412
Filaggrin in atopic dermatitis
O'Regan, G. M., Sandilands, A., McLean, W. H. I., & Irvine, A. D. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.08.002 · Cited by 350
Self-citationCorrigan, R. M., Miajlovic, H., & Foster, T. J. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-22 · Cited by 226
Self-citationThe Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin
Clarke, S. R., Mohamed, R., Bian, L., Routh, A. F., Kokai-Kun, J. F., Mond, J. J., Tarkowski, A., & Foster, S. J. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.04.005 · Cited by 225 · cited 2×
“Expression of IsdA makes the surface of S aureus more hydrophilic, increasing resistance to lipids and cationic antimicrobial peptides found on skin.(13) A reduction in filaggrin breakdown products on AD skin, either because of FLG null alleles or secondary to a TH2 inflammation–driven decrease in FLG expression, may…”
BackgroundClarke, S. R., Brummell, K. J., Horsburgh, M. J., McDowell, P. W., Mohamad, S. A. S., Stapleton, M. R., Acevedo, J., Read, R. C., Day, N. P. J., Peacock, S. J., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/501471 · Cited by 208
Krien, P. M., & Kermici, M. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00083.x · Cited by 151
Clarke, S. R., Andre, G., Walsh, E. J., Dufrêne, Y. F., Foster, T. J., & Foster, S. J. (2009) · Infection and Immunity · doi:10.1128/iai.01304-08 · Cited by 105
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Cited by
Weidinger, S., & Novak, N. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00149-x · Cited by 1,908
Weidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0001-z · Cited by 1,549
Self-citationFilaggrin Mutations Associated with Skin and Allergic Diseases
Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217
Self-citationAtopic dermatitis: a disease of altered skin barrier and immune dysregulation
Boguniewicz, M., & Leung, D. Y. M. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01027.x · Cited by 1,073
One remarkable molecule: filaggrin
Brown, S. J., & Irwin McLean, W. H. (2012) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.393 · Cited by 527
Metadata
- Authors
- Miajlovic, H., Fallon, P. G., Irvine, A. D., & Foster, T. J.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 126
- Issue
- 6
- Pages
- 1184-1190.e3
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2115672863
- Cited by
- 241
- References
- 10
- FWCI
- 14.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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