Cited by 412Antimicrobial Resistance in StaphylococcusImmune Response and InflammationNF-κB Signaling Pathways

Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1

Gómez, Marisa I, Lee, Aram, Reddy, Bharat, Muir, Amanda, Soong, Grace, Pitt, Allyson, Cheung, Ambrose, Prince, Alice·2004·Nature Medicine

Abstract

Staphylococcus aureus is a major human pathogen that is associated with diverse types of local and systemic infection characterized by inflammation dominated by polymorphonuclear leukocytes. Staphylococci frequently cause pneumonia, and these clinical isolates often have increased expression of protein A, suggesting that this protein may have a role in virulence. Here we show that TNFR1, a receptor for tumor-necrosis factor-alpha (TNF-alpha) that is widely distributed on the airway epithelium, is a receptor for protein A. We also show that the protein A-TNFR1 signaling pathway has a central role in the pathogenesis of staphylococcal pneumonia.

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Crossref · 10.1038/nm1079

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Authors
Gómez, M. I., Lee, A., Reddy, B., Muir, A., Soong, G., Pitt, A., Cheung, A., & Prince, A.
Affiliations
  • Columbia University (US)
  • Dartmouth College (US)
Corresponding author
Prince, Alice
Venue
Nature Medicine
Published
2004-07-11
Volume
10
Issue
8
Pages
842-848
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
OpenAlex
W1988700176
Cited by
412
References
29
Citations by year
2026: 9 · 2025: 9 · 2024: 12 · 2023: 19 · 2022: 12 · 2021: 15 · 2020: 12 · 2019: 17 · 2018: 15 · 2017: 19 · 2016: 23 · 2015: 17 · 2014: 23 · 2013: 15 · 2012: 24
FWCI
15.03
Type
journal article
Language
en
Open access
closed
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL079395)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords
Staphylococcus aureus, protein A, TNFR1, airway epithelium, inflammation, staphylococcal pneumonia, virulence factors, receptor signaling, polymorphonuclear leukocytes
MeSH terms
Animals, Cell Line, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Humans, Immunohistochemistry, Lung, Mice, Inbred C57BL, Neutrophils, Pneumonia, Staphylococcal, Staphylococcal Protein A, Staphylococcus aureus, Blotting, Western, Signal Transduction, Interleukin-8, Receptors, Tumor Necrosis Factor, Microscopy, Confocal, Respiratory Mucosa, Mice

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