The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
Open accessAbstract
Background Improvement in lung function following macrolide antibiotic therapy has been attributed to reduction in bronchial infection due to specific bacteria. However, the airway may be populated by a more diverse microbiota, and clinical features of asthma may be associated with characteristics of the airway microbiota present. Objective To determine if relationships exist between the composition of the airway bacterial microbiota and clinical features of asthma, using culture-independent tools capable of detecting the presence and relative abundance of most known bacteria. Methods In this pilot study, bronchial epithelial brushings were collected from sixty-five adults with sub-optimally controlled asthma participating in a multicenter study of the effects of clarithromycin on asthma control, and ten healthy subjects. A combination of high-density 16S rRNA microarray and parallel clone library-sequencing analysis was used to profile the microbiota and examine relationships with clinical measurements. Results Compared to controls, 16S rRNA amplicon concentrations (a proxy for bacterial burden) and bacterial diversity were significantly higher among asthmatic patients. In multivariate analyses, airway microbiota composition and diversity were significantly correlated with bronchial hyperresponsiveness. Specifically, the relative abundance of particular phylotypes, including members of the Comamonadaceae, Sphingomonadaceae, Oxalobacteraceae and other bacterial families, were highly correlated with the degree of bronchial hyperresponsiveness. Conclusion The composition of bronchial airway microbiota is associated with the degree of bronchial hyperresponsiveness among patients with sub-optimally controlled asthma. These findings support the need for further functional studies to examine the potential contribution of members of the airway microbiota in asthma pathogenesis.
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Cites
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Cited by
Microbiota in health and diseases
Hou, K., Wu, Z.-X., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00974-4 · Cited by 3,171
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“During states of ill health, such as viral upper respiratory tract infections, allergies, or sinus infections, the liquid flow from the nasal cavity increases, and this clearly has the potential to affect the lung microbiome, consistent with studies of rhinovirus infection and asthmatics that highlighted changes in th…”
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Metadata
- Authors
- Huang, Y. J., Nelson, C. E., Brodie, E. L., DeSantis, T. Z., Baek, M. S., Liu, J., Woyke, T., Allgaier, M., Bristow, J., Wiener-Kronish, J. P., Sutherland, E. R., King, T. S., Icitovic, N., Martin, R. J., Calhoun, W. J., Castro, M., Denlinger, L. C., DiMango, E., Kraft, M., Peters, S. P., Wasserman, S. I., Wechsler, M. E., Boushey, H. A., & Lynch, S. V.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 127
- Issue
- 2
- Pages
- 372-381.e3
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2158976881
- Cited by
- 696
- References
- 10
- FWCI
- 20.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Huang, Y. J., Nelson, C. E., Brodie, E. L., DeSantis, T. Z., Baek, M. S., Liu, J., Woyke, T., Allgaier, M., Bristow, J., Wiener-Kronish, J. P., Sutherland, E. R., King, T. S., Icitovic, N., Martin, R. J., Calhoun, W. J., Castro, M., Denlinger, L. C., DiMango, E., Kraft, M., . . . Lynch, S. V. (2011). Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2010.10.048
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