Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis
Gevaert, Philippe, Van Bruaene, Nicholas, Cattaert, Tom, Van Steen, Kristel, Van Zele, Thibaut, Acke, Frederic, De Ruyck, Natalie, Blomme, Katrien, Sousa, Ana R., Marshall, Richard P., Bachert, Claus·2011·Journal of Allergy and Clinical Immunology
Cited by (629)
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- Comparative efficacy and safety of monoclonal antibodies biologic therapies for chronic rhinosinusitis with nasal polyps: A systematic review and network meta-analysisAbdulhakeem Almutairi, Lina Yousef Aloraini, Bader Muzhier Alshahrani, Maan Omar Alzuhairi, Rabab Hussain Alzanadi, Khalid Alanazi, Yahya Ali Khubrani, Ahmed Y. Azzam · 2025 · American Journal of Otolaryngology
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- Additional file 1 of Mepolizumab improvements in health-related quality of life and disease symptoms in a patient population with very severe chronic rhinosinusitis with nasal polyps: psychometric and efficacy analyses from the SYNAPSE studyWytske Johanna Fokkens, Andrew Trigg, Lee, Stella E., Robert H. Chan, Diamant, Zuzana, Claire L Hopkins, Howarth, Peter, Valerie Joan Lund, Bhabita Mayer, Ana R. Sousa et al. · 2023 · Figshare
- Aspirin-Exacerbated Respiratory DiseaseMark Arnold, Joshua M. Levy · 2025 · Springer eBooks
- Outcomes of Maximal Conventional Therapy Before Biological Treatment in Recurrent Chronic Rhinosinusitis With Nasal PolypsYunus Emre Topan, Nuray Bayar Muluk, Ramazan Yavuz, Necat Alataş, Cemal Cingi · 2026 · Journal of Craniofacial Surgery
- Polypose naso-sinusienne : rôle des facteurs inflammatoires dans les dysfonctions épithéliales et perspectives thérapeutiquesÉmilie Béquignon · 2019 · theses.fr (ABES)
- Impact du microbiote et de la réponse inflammatoire de type 2 (lgE et éosinophiles) en contexte allo-immun : l'exemple de la transplantation rénaleLuc Colas · 2021 · theses.fr (ABES)
- Targeting Type-2 inflammation in chronic rhinosinusitis with nasal polyps: mechanisms, eosinophilia, and emerging therapiesSahar Khorasani, Mohammad Hasan Yousefi, Somayeh Safarirad, Hamed Afkhami, Azin Khodadadi · 2026 · European journal of medical research
- Real-world impact of mepolizumab on symptom control and health utility in severe chronic rhinosinusitis with nasal polyps: the RINOSUR 2.0 multicenter cohort studyRocio Corrales-Millán, Juan Maza‐Solano, Juan Ramón Benito Navarro, Virginia García‐García, María José Gámiz-Maroto, Juan Andrés Márquez-Moyano, Lucía Prieto-Sánchez-de-Puerta, Andrés Caballero García, Dionisio Guillamón-Fernández, Manuel Ortiz-Rueda et al. · 2026 · European Archives of Oto-Rhino-Laryngology
- Real-Life Effectiveness of Mepolizumab in Severe Type-2 Chronic Rhinosinusitis with Nasal Polyps: Clinical Outcomes and Predictors of ResponseSante De Santis, Stefania Galassi, Jacopo Cambi · 2026 · International Archives of Allergy and Immunology
- Eosinophils as immunoregulatory players in allergic rhinitis: beyond cytotoxicityX D Han, Feng Li, Feihu Wu, Chunsong Liu, Qiqi Yang, Yan Ruan, Weiping He, Wenda Feng, Gang Liu, Chunqiao Li · 2026 · Frontiers in Immunology
- Improved VO 2 max following anti-IL-5 therapy in severe eosinophilic CRSwNP: exploratory associations with cardiac inflammatory biomarkersJens Even Tidemandsen, K Rossing, Anne‐Sophie Homøe, Morten Hostrup, Vibeke Backer · 2026 · European Clinical Respiratory Journal
- Uncontrolled Status, Disease Burden, and Associated Risk Factors Among Patients with Asthma Receiving Medium-to-High Dose ICS or ICS/LABA: A Retrospective AnalysisHonglei Shi, Ying Wang, Min Wang, Dan Shen, Huang Kw · 2026 · Advances in Therapy
- Dose tapering and treatment de-escalation of biologic therapies in chronic rhinosinusitis with nasal polyps: a narrative reviewSalma Alsharhan, Hussain J Aljubran · 2026 · Frontiers in Surgery
- Postoperative Management of Patients with Eosinophilic Chronic RhinosinusitisKosuke Akiyama · 2026 · Practica Oto-Rhino-Laryngologica
- Role of Nasal Endoscopy in Diagnosis of ENPSara Maurantonio, Goran Latif Omer, Sahand Soran Ali, Rekawt Hama Rashid Kareem, Iacopo Dallan, Stefano Di Girolamo, Roy R. Casiano · 2026 · Springer eBooks
- Biologic Therapies for ENP: Anti–IL-4, IL-5, and IL-13 PathwaysMohamed Samy Elwany, Mohamed Shehata Taha · 2026 · Springer eBooks
- Chronic Rhinosinusitis with Nasal Polyps: T-Cell Dysregulation and Regulatory T-Cell DysfunctionEbrahim Farashi, Tolani F. Olonisakin, Joshua M. Levy, Nyall R. London · 2026 · Current Otorhinolaryngology Reports