Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis
Open accessAbstract
Background Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival. Objective We sought to investigate the therapeutic potential of inhibiting IL-5 with a humanized mAb as treatment for severe nasal polyposis. Methods Thirty patients with severe nasal polyposis (grade 3 or 4 or recurrent after surgery) refractory to corticosteroid therapy were randomized in a double-blind fashion to receive either 2 single intravenous injections (28 days apart) of 750 mg of mepolizumab (n = 20) or placebo (n = 10). Change from baseline in NP score was assessed monthly until 1 month after the last dose (week 8). Computed tomographic scans were also performed at week 8. Results Twelve of 20 patients receiving mepolizumab had a significantly improved NP score and computed tomographic scan score compared with 1 of 10 patients receiving placebo at week 8 versus baseline. Conclusion Mepolizumab achieved a statistically significant reduction in NP size for at least 1 month after dosing in 12 of 20 patients. IL-5 inhibition is a potential novel therapeutic approach in patients with severe eosinophilic nasal polyposis.
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Biological treatments have a potentially major effect on nasal obstruction and the size of nasal polyps in chronic rhinosinusitis with nasal polyps.
“These biological treatments have a potentially major effect on NO and the size of NP.”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [182]
The Primary end point: TPS section (page not available in our copy) reports a significant reduction in polyp score with mepolizumab versus placebo. The Symptom scores and nPIF section reports trends toward less congestion and better nasal airflow, but neither was statistically significant. This supports potential benefit from mepolizumab, not a major effect on obstruction or a general effect of biological treatments. (LLM, conf=0.86)
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- Authors
- Gevaert, P., Van Bruaene, N., Cattaert, T., Van Steen, K., Van Zele, T., Acke, F., De Ruyck, N., Blomme, K., Sousa, A. R., Marshall, R. P., & Bachert, C.
- Affiliations
- Ghent University (BE)
- University of Liège (BE)
- GlaxoSmithKline (United Kingdom) (GB)
- Corresponding author
- Gevaert, Philippe
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 128
- Issue
- 5
- Pages
- 989-995.e8
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1968876836
- Cited by
- 629
- References
- 31
- Citations by year
- 2026: 21 · 2025: 26 · 2024: 31 · 2023: 45 · 2022: 29 · 2021: 73 · 2020: 80 · 2019: 56 · 2018: 64 · 2017: 55 · 2016: 52 · 2015: 36 · 2014: 15 · 2013: 16 · 2012: 27
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Lirias (submittedVersion)
- ORBi (University of Liège) (submittedVersion)
- Funders
- GlaxoSmithKline
- Fonds De La Recherche Scientifique - FNRS
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Keywords
- mepolizumab, IL-5 inhibition, nasal polyps, eosinophilic rhinosinusitis, humanized monoclonal antibody, corticosteroid-refractory disease, eosinophilia, anti-IL-5 therapy
- MeSH terms
- Double-Blind Method, Eosinophilia, Female, Humans, Male, Middle Aged, Nasal Polyps, Interleukin-5, Eosinophil Cationic Protein, Antibodies, Monoclonal, Humanized
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