Cited by 629Sinusitis and nasal conditionsAsthma and respiratory diseasesCystic Fibrosis Research Advances

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Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis

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Gevaert, Philippe, Van Bruaene, Nicholas, Cattaert, Tom, Van Steen, Kristel, Van Zele, Thibaut, Acke, Frederic, De Ruyck, Natalie, Blomme, Katrien, Sousa, Ana R., Marshall, Richard P., Bachert, Claus·2011·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2011.07.056

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Abstract

Background Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival. Objective We sought to investigate the therapeutic potential of inhibiting IL-5 with a humanized mAb as treatment for severe nasal polyposis. Methods Thirty patients with severe nasal polyposis (grade 3 or 4 or recurrent after surgery) refractory to corticosteroid therapy were randomized in a double-blind fashion to receive either 2 single intravenous injections (28 days apart) of 750 mg of mepolizumab (n = 20) or placebo (n = 10). Change from baseline in NP score was assessed monthly until 1 month after the last dose (week 8). Computed tomographic scans were also performed at week 8. Results Twelve of 20 patients receiving mepolizumab had a significantly improved NP score and computed tomographic scan score compared with 1 of 10 patients receiving placebo at week 8 versus baseline. Conclusion Mepolizumab achieved a statistically significant reduction in NP size for at least 1 month after dosing in 12 of 20 patients. IL-5 inhibition is a potential novel therapeutic approach in patients with severe eosinophilic nasal polyposis.

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Authors: Gevaert, P., Van Bruaene, N., Cattaert, T., Van Steen, K., Van Zele, T., Acke, F., De Ruyck, N., Blomme, K., Sousa, A. R., Marshall, R. P., & Bachert, C.
Affiliations: Ghent University (BE)
University of Liège (BE)
GlaxoSmithKline (United Kingdom) (GB)
Corresponding author: Gevaert, Philippe
ORCID: Gevaert, Philippe
Acke, Frederic
Sousa, Ana R.
Marshall, Richard P.
Bachert, Claus
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2011-11
Volume: 128
Issue: 5
Pages: 989-995.e8
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2011.07.056
OpenAlex: W1968876836
Cited by: 629
References: 31
Citations by year: 2026: 21 · 2025: 26 · 2024: 31 · 2023: 45 · 2022: 29 · 2021: 73 · 2020: 80 · 2019: 56 · 2018: 64 · 2017: 55 · 2016: 52 · 2015: 36 · 2014: 15 · 2013: 16 · 2012: 27
FWCI: 17.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Lirias (submittedVersion)
ORBi (University of Liège) (submittedVersion)
Funders: GlaxoSmithKline
Fonds De La Recherche Scientifique - FNRS
Fonds Wetenschappelijk Onderzoek
Vlaamse regering
Topics: Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Keywords: mepolizumab, IL-5 inhibition, nasal polyps, eosinophilic rhinosinusitis, humanized monoclonal antibody, corticosteroid-refractory disease, eosinophilia, anti-IL-5 therapy
MeSH terms: Double-Blind Method, Eosinophilia, Female, Humans, Male, Middle Aged, Nasal Polyps, Interleukin-5, Eosinophil Cationic Protein, Antibodies, Monoclonal, Humanized

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Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis

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