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Mepolizumab, a humanized anti–IL-5 mAb, as a treatment option for severe nasal polyposis
Open accessAbstract
Background Approximately 85% of nasal polyps (NPs) in white subjects are characterized by prominent eosinophilia. IL-5 is the key driver of eosinophilic differentiation and survival. Objective We sought to investigate the therapeutic potential of inhibiting IL-5 with a humanized mAb as treatment for severe nasal polyposis. Methods Thirty patients with severe nasal polyposis (grade 3 or 4 or recurrent after surgery) refractory to corticosteroid therapy were randomized in a double-blind fashion to receive either 2 single intravenous injections (28 days apart) of 750 mg of mepolizumab (n = 20) or placebo (n = 10). Change from baseline in NP score was assessed monthly until 1 month after the last dose (week 8). Computed tomographic scans were also performed at week 8. Results Twelve of 20 patients receiving mepolizumab had a significantly improved NP score and computed tomographic scan score compared with 1 of 10 patients receiving placebo at week 8 versus baseline. Conclusion Mepolizumab achieved a statistically significant reduction in NP size for at least 1 month after dosing in 12 of 20 patients. IL-5 inhibition is a potential novel therapeutic approach in patients with severe eosinophilic nasal polyposis.
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“These biological treatments have a potentially major effect on NO and the size of NP.”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [182]
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Metadata
- Authors
- Gevaert, P., Van Bruaene, N., Cattaert, T., Van Steen, K., Van Zele, T., Acke, F., De Ruyck, N., Blomme, K., Sousa, A. R., Marshall, R. P., & Bachert, C.
- Affiliations
- Ghent University (BE)
- University of Liège (BE)
- GlaxoSmithKline (United Kingdom) (GB)
- Corresponding author
- Gevaert, Philippe
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 128
- Issue
- 5
- Pages
- 989-995.e8
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W1968876836
- Cited by
- 629
- References
- 31
- Citations by year
- 2026: 21 · 2025: 26 · 2024: 31 · 2023: 45 · 2022: 29 · 2021: 73 · 2020: 80 · 2019: 56 · 2018: 64 · 2017: 55 · 2016: 52 · 2015: 36 · 2014: 15 · 2013: 16 · 2012: 27
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Lirias (submittedVersion)
- ORBi (University of Liège) (submittedVersion)
- Funders
- GlaxoSmithKline
- Fonds De La Recherche Scientifique - FNRS
- Fonds Wetenschappelijk Onderzoek
- Vlaamse regering
- Topics
- Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Keywords
- mepolizumab, IL-5 inhibition, nasal polyps, eosinophilic rhinosinusitis, humanized monoclonal antibody, corticosteroid-refractory disease, eosinophilia, anti-IL-5 therapy
- MeSH terms
- Double-Blind Method, Eosinophilia, Female, Humans, Male, Middle Aged, Nasal Polyps, Interleukin-5, Eosinophil Cationic Protein, Antibodies, Monoclonal, Humanized
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