CoChat
Sign Up
Cited by 136Sinusitis and nasal conditionsNasal Surgery and Airway StudiesCystic Fibrosis Research Advances

A systematic review of the use of intranasal steroids in the treatment of chronic rhinosinusitis

Joe, Stephanie A., Thambi, Rakhi, Huang, Jie·2008·Otolaryngology–Head and Neck Surgery
DOI 10.1016/j.otohns.2008.05.628
Open this paper in CoChat — free account

Abstract

Objective To determine if intranasal steroids (INS) are useful in the management of chronic rhinosinusitis without polyps and chronic rhinosinusitis (CRS) with polyps. Data sources Studies for inclusion were searched using Medline, EMBASE, Cochrane databases, and references of included studies. Review methods Initial screening of article titles and abstracts obtained from the literature search was performed independently by two reviewers (SAJ and RT) based on the research protocol criteria. These articles then underwent a second-stage review. Each article was read in detail and discussed by the two reviewers before inclusion in the study. Results The review yielded 13 studies regarding the treatment of sinonasal polyps with intranasal steroids. Six of these could be included in the meta-analysis. The outcome measure used for meta-analysis was change in polyp size from baseline compared between the treatment and control groups. Results from both conservative and optimistic selection of treatment effect are positive, providing significant improvement in polyp size in the treatment group as compared to controls. In the conservative estimate, the mean improvement in polyp size score between the treatment and placebo group is 0.43 with a 95% CI of [0.25, 0.61]. Of those treatment groups with the largest improvement, the mean improvement in polyp size score can go as high as 0.63 with a 95% CI of [0.43, 0.82]. Conclusion Intranasal steroids are beneficial in the treatment of chroni…

Integrity signals

Registry

Crossref · 10.1016/j.otohns.2008.05.628

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Intranasal corticosteroids improve NO, edema, polyp size, and recurrence after surgery.

    “They improve NO, as well as edema, polyp size [136,137], and recurrence after surgery [138].”

    From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [136]

Cites

  • Publication bias in clinical research

    Easterbrook, P. J., Gopalan, R., Berlin, J. A., & Matthews, D. R. (1991) · The Lancet · doi:10.1016/0140-6736(91)90201-y · Cited by 3,109 · cited 2× · see citing works

    “It has been said that reports with significant results are more likely to be published and receive more attention, resulting in potential publication bias.(17,18) However, we feel that restricting our study to the use of randomized, blinded, controlled studies minimizes this bias.”
    BackgroundResult

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Joe, S. A., Thambi, R., & Huang, J.
Affiliations
  • University of Illinois Chicago (US)
  • Northwestern University (US)
Corresponding author
Joe, Stephanie A.
Venue
Otolaryngology–Head and Neck Surgery
Publisher
Wiley
Published
2008-09
Volume
139
Issue
3
Pages
340-347
ISSN
  • 0161-6439 (ISSN-L)
  • 0194-5998
  • 1097-6817
DOI
10.1016/j.otohns.2008.05.628
OpenAlex
W2067311037
Cited by
136
References
1
Citations by year
2026: 3 · 2025: 6 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 7 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 14 · 2012: 13
FWCI
2.11
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Otolaryngology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
  • Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Keywords
intranasal corticosteroids, chronic rhinosinusitis, chronic rhinosinusitis with nasal polyps, sinonasal polyps, polyp size reduction
MeSH terms
Administration, Intranasal, Chronic Disease, Glucocorticoids, Humans, Rhinitis, Sinusitis, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review