The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Natural killer cell biology: An update and future directions
Open accessAbstract
Natural killer (NK) cells constitute a minor subset of normal lymphocytes that initiate innate immune responses toward tumor and virus-infected cells. They can mediate spontaneous cytotoxicity toward these abnormal cells and rapidly secrete numerous cytokines and chemokines to promote subsequent adaptive immune responses. Significant progress has been made in the past two decades to improve our understanding of NK cell biology. Here we review recent discoveries, including a better comprehension of the “education” of NK cells to achieve functional competence during their maturation and the discovery of “memory” responses by NK cells suggesting that they may also contribute to adaptive immunity. The improved understanding of NK cell biology has forged greater awareness that these cells play integral early roles in immune responses. In addition, several promising clinical therapies have been used to exploit NK cell functions in treating cancer patients. As our molecular understanding improves, these and future immunotherapies should continue to provide promising strategies to exploit the unique functions of NK cells to treat cancer, infections, and other pathological conditions.
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1 retracted
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Immunometabolism and natural killer cell responses
O’Brien, K. L., & Finlay, D. K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0139-2 · Cited by 435
Cancer Immunotherapy Based on Natural Killer Cells: Current Progress and New Opportunities
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Lo Nigro, C., Macagno, M., Sangiolo, D., Bertolaccini, L., Aglietta, M., & Merlano, M. C. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.01.42 · Cited by 268
On the immunological theory of aging
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Obesity associated disease risk: the role of inherent differences and location of adipose depots
Hill, J. H., Solt, C., & Foster, M. T. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0012 · Cited by 79
Metadata
- Authors
- Campbell, K. S., & Hasegawa, J.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 132
- Issue
- 3
- Pages
- 536-544
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2015912224
- Cited by
- 416
- References
- 112
- FWCI
- 16.99
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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