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Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
Abstract
Stress-inducible MICA, a distant homolog of major histocompatibility complex (MHC) class I, functions as an antigen for γδ T cells and is frequently expressed in epithelial tumors. A receptor for MICA was detected on most γδ T cells, CD8 + αβ T cells, and natural killer (NK) cells and was identified as NKG2D. Effector cells from all these subsets could be stimulated by ligation of NKG2D. Engagement of NKG2D activated cytolytic responses of γδ T cells and NK cells against transfectants and epithelial tumor cells expressing MICA. These results define an activating immunoreceptor-MHC ligand interaction that may promote antitumor NK and T cell responses.
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Research works printed but not linked: 23
- 10.1146/annurev.immunol.16.1.359 · DOI · Paper page
- Yokoyama W. M., Curr. Opin. Immunol. 10, 298 (1998). · DOI
- 10.1126/science.7716543 · DOI · Paper page
- ; N. Wagtmann et al. Immunity 2 439 (1995). · DOI · Paper page
- Chang C., Eur. J. Immunol. 25, 2433 (1995); · doi:10.1002/eji.1830250904
- Brooks A. G., Posch P. E., Scorzelli C. J., Borrego F., Coligan J. E., J. Exp. Med. 185, 795 (1997). · DOI · Paper page
- V. M. Braud et al. Nature 391 795 (1998) · DOI · Paper page
- N. Lee et al. Proc. Natl. Acad. Sci. U.S.A. 95 5199 (1998). · DOI · Paper page
- 10.1126/science.7716542 · DOI · Paper page
- Carena I., Shamshiev A., Donda A., Colonna M., De Libero G., J. Exp. Med. 186, 1769 (1997); · DOI
- 10.1038/319675a0 · DOI · Paper page
- V. Groh et al. Proc. Natl. Acad. Sci. U.S.A. 93 12445 (1996). · DOI · Paper page
- 10.1126/science.279.5357.1737 · DOI · Paper page
- V. Groh et al. Proc. Natl. Acad. Sci. U.S.A. 96 6879 (1999). · DOI · Paper page
- Bauer S., Willie S. T., Spies T., Strong R. K., Acta Crystallogr. D 54, 451 (1998); · doi:10.1107/s0907444997015229
- Hubank M., Schatz D. G., Nucleic Acids Res. 22, 5640 (1994); · DOI · Paper page
- 10.1126/science.8438152 · DOI · Paper page
- 10.1084/jem.173.4.1017 · DOI · Paper page
- ; T. Yabe et al. Immunogenetics 37 455 (1993). · DOI
- 10.1126/science.285.5428.730 · DOI · Paper page
- 10.1126/science.270.5233.105 · DOI
- Lanier L. L., Corliss B., Wu J., Phillips J. H., Immunity 8, 693 (1998). · DOI · Paper page
- M. J. Robertson et al. Exp. Hematol. 24 406 (1996). · doi:10.1177/009182969602400315
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Self-citation
Metadata
- Authors
- Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L., & Spies, T.
- Venue
- Science
- Published
- 1999-07-30
- Volume
- 285
- Issue
- 5428
- Pages
- 727-729
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2170069789
- Cited by
- 2,999
- References
- 0
- FWCI
- 31.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bauer, S., Groh, V., Wu, J., Steinle, A., Phillips, J. H., Lanier, L. L., & Spies, T. (1999). Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA. Science. https://doi.org/10.1126/science.285.5428.727
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