Associations between outdoor fungal spores and childhood and adolescent asthma hospitalizations
Open accessAbstract
Background Childhood asthma is a significant public health problem and severe exacerbations can result in diminished quality of life and hospitalization.Objective We sought to examine the contribution of outdoor fungi to childhood and adolescent asthma hospitalizations.Methods The Melbourne Air Pollen Children and Adolescent study is a case-crossover study of 644 children and adolescents (aged 2-17 years) hospitalized for asthma. The Melbourne Air Pollen Children and Adolescent study collected individual data on human rhinovirus infection and sensitization to Alternaria and Cladosporium and daily counts of ambient concentrations of fungal spores, pollen, and air pollutants. Conditional logistic regression models were used to assess associations with increases in spore counts while controlling for potential confounding and testing interactions.Results Exposure to Alternaria (adjusted odds ratio [aOR], 1.07; 95% CI, 1.03-1.11), Leptosphaeria (aOR, 1.05; 95% CI, 1.02-1.07), Coprinus (aOR, 1.04; 95% CI, 1.01-1.07), Drechslera (aOR, 1.03; 95% CI, 1.00-1.05), and total spores (aOR, 1.05; 95% CI, 1.01-1.09) was significantly associated with child asthma hospitalizations independent of human rhinovirus infection. There were significant lagged effects up to 3 days with Alternaria, Leptosphaeria, Cladosporium, Sporormiella, Coprinus, and Drechslera. Some of these associations were significantly greater in participants with Cladosporium sensitization.Conclusions Exposures to several outdoor fungal spore taxa, including some not reported in previous research, are associated with the risk of child and adolescent asthma hospitalization, particularly in individuals sensitized to Cladosporium. We need further studies to examine cross-reactivity causing asthma exacerbations. Identifying sensitization to multiple fungal allergens in children with asthma could support the design and implementation of more effective strategies to prevent asthma exacerbations.
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Asthmatic children are susceptible to exacerbations that lead to hospitalization when exposed to outdoor fungal spores.
“In relation to other outdoor allergens, increasing evidence indicates that asthmatic children are susceptible to exacerbations that lead to hospitalization when exposed to outdoor fungal spores (104).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [104]
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Fungal Spore Seasons Advanced Across the US Over Two Decades of Climate Change
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The Impact of Air Pollution and Aeroallergens Levels on Upper Airway Acute Diseases at Urban Scale
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Indoor and Outdoor Fungal Allergens and Impacts on Respiratory Allergic Disease
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Aeroallergens Exacerbate Histoplasma capsulatum Infection
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Unraveling the Exposome in Direct and Indirect Respiratory Effects of Climate Change
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- Authors
- Tham, R., Vicendese, D., Dharmage, S. C., Hyndman, R. J., Newbigin, E., Lewis, E., O'Sullivan, M., Lowe, A. J., Taylor, P., Bardin, P., Tang, M. L. K., Abramson, M. J., & Erbas, B.
- Affiliations
- The University of Melbourne (AU)
- La Trobe University (AU)
- Monash University (AU)
- Royal Children's Hospital (AU)
- Deakin University (AU)
- Monash Medical Centre (AU)
- Corresponding author
- Erbas, Bircan
- ORCID
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 139
- Issue
- 4
- Pages
- 1140-1147.e4
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2508618351
- Cited by
- 99
- References
- 41
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 9 · 2023: 8 · 2022: 11 · 2021: 16 · 2020: 12 · 2019: 14 · 2018: 13 · 2017: 3 · 2016: 1
- FWCI
- 8.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- childhood asthma, adolescent asthma, asthma hospitalization, asthma exacerbations, Alternaria, Cladosporium, fungal sensitization, Leptosphaeria, Coprinus, Drechslera, Sporormiella, lagged exposure effects, allergen cross-reactivity
- MeSH terms
- Adolescent, Air Pollutants, Asthma, Australia, Child, Child, Preschool, Environmental Exposure, Female, Hospitalization, Humans, Hypersensitivity, Male, Skin Tests, Spores, Fungal, Cross-Over Studies
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