Fungi: the neglected allergenic sources
Open accessAbstract
Allergic diseases are considered the epidemics of the twentieth century estimated to affect more than 30% of the population in industrialized countries with a still increasing incidence. During the past two decades, the application of molecular biology allowed cloning, production and characterization of hundreds of recombinant allergens. In turn, knowledge about molecular, chemical and biologically relevant allergens contributed to increase our understanding of the mechanisms underlying IgE-mediated type I hypersensitivity reactions. It has been largely demonstrated that fungi are potent sources of allergenic molecules covering a vast variety of molecular structures including enzymes, toxins, cell wall components and phylogenetically highly conserved cross-reactive proteins. Despite the large knowledge accumulated and the compelling evidence for an involvement of fungal allergens in the pathophysiology of allergic diseases, fungi as a prominent source of allergens are still largely neglected in basic research as well as in clinical practice. This review aims to highlight the impact of fungal allergens with focus on asthma and atopic dermatitis.
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Use of purified recombinant A. fumigatus allergens has the potential to substantially increase the specificity and sensitivity of diagnosis of A. fumigatus-related diseases, including ABPA.
“Use of purified recombinant A. fumigatus allergens (see the allergome database www.allergome.org for the recombinant A. fumigatus allergens, developed by R. Crameri [52, 53]) has the potential to substantially increase the specificity and sensitivity of diagnosis of A. fumigatus-related diseases, including ABPA.”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [52]
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Aspergillus fumigatus and Aspergillosis in 2019
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Self-citation
- Authors
- Crameri, R., Garbani, M., Rhyner, C., & Huitema, C.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Crameri, R.
- Venue
- Allergy
- Publisher
- Wiley
- Published
- 2013-11-29
- Volume
- 69
- Issue
- 2
- Pages
- 176-185
- ISSN
- 0105-4538 (ISSN-L)
- OpenAlex
- W1994151427
- Cited by
- 207
- References
- 157
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 19 · 2023: 20 · 2022: 18 · 2021: 15 · 2020: 16 · 2019: 13 · 2018: 14 · 2017: 19 · 2016: 21 · 2015: 15 · 2014: 9
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- green
- zenodo.org
- Licence
- Locations
- Allergy (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
- Keywords
- fungal allergens, allergic diseases, asthma, atopic dermatitis, IgE-mediated hypersensitivity, immediate hypersensitivity, recombinant allergens, mycotoxins, fungal enzymes, fungal cell wall components
- MeSH terms
- Antigens, Fungal, Fungi, Humans, Hypersensitivity, Molecular Sequence Data
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