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Substance P activates Mas-related G protein–coupled receptors to induce itch
Open accessAbstract
Background Substance P (SP) is linked to itch and inflammation through activation of receptors on mast cells and sensory neurons. There is increasing evidence that SP functions through Mas‐related G protein–coupled receptors (Mrgprs) in addition to its conventional receptor, neurokinin‐1. Objective Because Mrgprs mediate some aspects of inflammation that had been considered mediated by neurokinin‐1 receptor (NK‐1R), we sought to determine whether itch induced by SP can also be mediated by Mrgprs. Methods Genetic and pharmacologic approaches were used to evaluate the contribution of Mrgprs to SP‐induced scratching behavior and activation of cultured dorsal root ganglion neurons from mice. Results SP‐induced scratching behavior and activation of cultured dorsal root ganglion neurons was dependent on Mrgprs rather than NK‐1R. Conclusion We deduce that SP activates MrgprA1 on sensory neurons rather than NK‐1R to induce itch.
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Citations
Cited by
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Bieber, T. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00266-6 · Cited by 623
Perner, C., Flayer, C. H., Zhu, X., Aderhold, P. A., Dewan, Z. N. A., Voisin, T., Camire, R. B., Chow, O. A., Chiu, I. M., & Sokol, C. L. (2020) · Immunity · doi:10.1016/j.immuni.2020.10.001 · Cited by 313
Physiology and Pathophysiology of Itch
Cevikbas, F., & Lerner, E. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00017.2019 · Cited by 282
Self-citationThe Itch–Scratch Cycle: A Neuroimmune Perspective
Mack, M. R., & Kim, B. S. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.10.001 · Cited by 255
Peripheral itch sensitization in atopic dermatitis
Tominaga, M., & Takamori, K. (2022) · Allergology International · doi:10.1016/j.alit.2022.04.003 · Cited by 160
Metadata
- Authors
- Azimi, E., Reddy, V. B., Pereira, P. J. S., Talbot, S., Woolf, C. J., & Lerner, E. A.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 140
- Issue
- 2
- Pages
- 447-453.e3
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2589947839
- Cited by
- 197
- References
- 0
- FWCI
- 11.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Azimi, E., Reddy, V. B., Pereira, P. J. S., Talbot, S., Woolf, C. J., & Lerner, E. A. (2017). Substance P activates Mas-related G protein–coupled receptors to induce itch. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2016.12.980
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