The DOI matches its Crossref record; 302 of the 302 references it cites were found in a registry or an index.
Physiology and Pathophysiology of Itch
Open accessAbstract
Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly understood and appreciated. The pathophysiological consequences of itch impact quality of life as much as pain. These dynamics have led to increasingly deep dives into the mechanisms that underlie and contribute to the sensation of itch. When the prior review on the physiology of itching was published in this journal in 1941, itch was a black box of interest to a small number of neuroscientists and dermatologists. Itch is now appreciated as a complex and colorful Rubik’s cube. Acute and chronic itch are being carefully scratched apart and reassembled by puzzle solvers across the biomedical spectrum. New mediators are being identified. Mechanisms blur boundaries of the circuitry that blend neuroscience and immunology. Measures involve psychophysics and behavioral psychology. The efforts associated with these approaches are positively impacting the care of itchy patients. There is now the potential to markedly alleviate chronic itch, a condition that does not end life, but often ruins it. We review the itch field and provide a current understanding of the pathophysiology of itch. Itch is a disease, not only a symptom of disease.
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1 retracted
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Cited by
Peripheral itch sensitization in atopic dermatitis
Tominaga, M., & Takamori, K. (2022) · Allergology International · doi:10.1016/j.alit.2022.04.003 · Cited by 160
Itch in Atopic Dermatitis – What Is New?
Legat, F. J. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.644760 · Cited by 82
Expectancies and avoidance: Towards an integrated model of chronic somatic symptoms
Nadinda, P. G., van Laarhoven, A. I. M., Van den Bergh, O., Vlaeyen, J. W. S., Peters, M. L., & Evers, A. W. M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105808 · Cited by 15
Metadata
- Authors
- Cevikbas, F., & Lerner, E. A.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2020-07-01
- Volume
- 100
- Issue
- 3
- Pages
- 945-982
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2997548580
- Cited by
- 282
- References
- 302
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Cevikbas, F., & Lerner, E. A. (2020). Physiology and Pathophysiology of Itch. Physiological Reviews. https://doi.org/10.1152/physrev.00017.2019
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
