Cited by 2,425MicroRNA in disease regulationRNA Interference and Gene DeliveryPlant Molecular Biology Research

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MicroRNA

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Lu, Thomas X., Rothenberg, Marc E.·2018·Journal of Allergy and Clinical Immunology

DOI 10.1016/j.jaci.2017.08.034PMC PMC5889965

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Abstract

MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development. MiRNA mimics and miRNA inhibitors currently in preclinical development have shown promise as novel therapeutic agents. Multiple technological platforms have been developed for miRNA isolation, miRNA quantitation, miRNA profiling, miRNA target detection, and modulating miRNA levels in vitro and in vivo. Here we will review the major technological platforms with consideration given for the advantages and disadvantages of each platform.

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Authors: Lu, T. X., & Rothenberg, M. E.
Affiliations: University of Chicago (US)
Cincinnati Children's Hospital Medical Center (US)
Corresponding author: Rothenberg, Marc E.
ORCID: Lu, Thomas X.
Rothenberg, Marc E.
Venue: Journal of Allergy and Clinical Immunology
Publisher: Elsevier BV
Published: 2018-04
Volume: 141
Issue: 4
Pages: 1202-1207
ISSN: 0091-6749 (ISSN-L)
DOI: 10.1016/j.jaci.2017.08.034
PMC: PMC5889965
OpenAlex: W4247544731
Cited by: 2,425
References: 43
Citations by year: 2026: 168 · 2025: 300 · 2024: 397 · 2023: 455 · 2022: 478 · 2021: 431 · 2020: 184 · 2019: 11 · 2018: 1
FWCI: 5.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Allergy and Clinical Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R37AI045898, R01AI124355)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA, allergy, post-transcriptional regulation, biomarkers, miRNA mimics, miRNA inhibitors, miRNA expression profiling
MeSH terms: Gene Expression Regulation, Genetic Markers, Humans, Hypersensitivity, MicroRNAs, In Vitro Techniques

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