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MicroRNA
Open accessAbstract
MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development. MiRNA mimics and miRNA inhibitors currently in preclinical development have shown promise as novel therapeutic agents. Multiple technological platforms have been developed for miRNA isolation, miRNA quantitation, miRNA profiling, miRNA target detection, and modulating miRNA levels in vitro and in vivo. Here we will review the major technological platforms with consideration given for the advantages and disadvantages of each platform.
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“Non-coding microRNAs (miRNAs) can post-transcriptionally regulate the mRNA expression by targeting the 3ʹ-UTR region, and thus play a significant role in various cellular functions such as differentiation, proliferation and apoptosis.15,16”
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Metadata
- Authors
- Lu, T. X., & Rothenberg, M. E.
- Affiliations
- University of Chicago (US)
- Cincinnati Children's Hospital Medical Center (US)
- Corresponding author
- Rothenberg, Marc E.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 141
- Issue
- 4
- Pages
- 1202-1207
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC5889965
- OpenAlex
- W4247544731
- Cited by
- 2,425
- References
- 43
- Citations by year
- 2026: 168 · 2025: 300 · 2024: 397 · 2023: 455 · 2022: 478 · 2021: 431 · 2020: 184 · 2019: 11 · 2018: 1
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R37AI045898, R01AI124355)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- microRNA, allergy, post-transcriptional regulation, biomarkers, miRNA mimics, miRNA inhibitors, miRNA expression profiling
- MeSH terms
- Gene Expression Regulation, Genetic Markers, Humans, Hypersensitivity, MicroRNAs, In Vitro Techniques
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