Evolution of IgE responses to multiple allergen components throughout childhood
Open accessAbstract
BACKGROUND: There is a paucity of information about longitudinal patterns of IgE responses to allergenic proteins (components) from multiple sources. OBJECTIVES: This study sought to investigate temporal patterns of component-specific IgE responses from infancy to adolescence, and their relationship with allergic diseases. METHODS: In a population-based birth cohort, we measured IgE to 112 components at 6 follow-ups during childhood. We used a Bayesian method to discover cross-sectional sensitization patterns and their longitudinal trajectories, and we related these patterns to asthma and rhinitis in adolescence. RESULTS: We identified 1 sensitization cluster at age 1, 3 at age 3, 4 at ages 5 and 8, 5 at age 11, and 6 at age 16 years. "Broad" cluster was the only cluster present at every follow-up, comprising components from multiple sources. "Dust mite" cluster formed at age 3 years and remained unchanged to adolescence. At age 3 years, a single-component "Grass" cluster emerged, which at age 5 years absorbed additional grass components and Fel d 1 to form the "Grass/cat" cluster. Two new clusters formed at age 11 years: "Cat" cluster and "PR-10/profilin" (which divided at age 16 years into "PR-10" and "Profilin"). The strongest contemporaneous associate of asthma at age 16 years was sensitization to dust mite cluster (odds ratio: 2.6; 95% CI: 1.2-6.1; P < .05), but the strongest early life predictor of subsequent asthma was sensitization to grass/cat cluster (odds ratio: 3.5; 95% CI: 1.6-7.4; P < .01). CONCLUSIONS: We describe the architecture of the evolution of IgE responses to multiple allergen components throughout childhood, which may facilitate development of better diagnostic and prognostic biomarkers for allergic diseases.
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Studies using component-resolved diagnostics have identified different cross-sectional and longitudinal patterns of component-specific IgE responses associated with different risk of asthma presence, persistence and severity in children.
“Further studies using component-resolved diagnostics rather than standard skin and blood tests to whole allergen extracts have identified different cross-sectional and longitudinal patterns of component-specific IgE responses associated with different risk of asthma presence, persistence and severity in children (90–93).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [92]
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- Authors
- Howard, R., Belgrave, D., Papastamoulis, P., Simpson, A., Rattray, M., & Custovic, A.
- Affiliations
- University of Manchester (GB)
- Imperial College London (GB)
- Manchester Academic Health Science Centre (GB)
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 142
- Issue
- 4
- Pages
- 1322-1330
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC6170973
- OpenAlex
- W2786087662
- Cited by
- 75
- References
- 41
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 10 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 12 · 2019: 11 · 2018: 5
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc-nd)
- Funders
- UK Medical Research Council (MR/K002449/1, MR/LO12693/1)
- MRC Health eResearch Centre (MR/K006665/1)
- MRC Career Development (MRC MR/M015181/1)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Keywords
- IgE sensitization, allergen components, pediatric allergy, asthma, rhinitis, dust mites, grass pollen, Fel d 1, cat allergen, profilin, PR-10, birth cohort
- MeSH terms
- Adolescent, Allergens, Asthma, Bayes Theorem, Child, Child, Preschool, Humans, Immunoglobulin E, Infant, Male, Rhinitis
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