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Cited by 61Sinusitis and nasal conditionsCystic Fibrosis Research AdvancesAsthma and respiratory diseases

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Cross-talk between TH2 and TH17 pathways in patients with chronic rhinosinusitis with nasal polyps

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Wang, Min, Zhang, Nan, Zheng, Ming, Li, Ying, Meng, Lingling, Ruan, Yu, Han, Jinbo, Zhao, Na, Wang, Xiangdong, Zhang, Luo, Bachert, Claus·2019·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2019.06.023
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Abstract

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease with a spectrum of endotypes. T H 2- and T H 17-related cytokines are 2 central regulators involved in the inflammation associated with CRSwNP. Objective We sought to investigate the interregulation of T H 2 and T H 17 pathways in Chinese patients with CRSwNP. Methods Levels of key T H 2- and T H 17-related factors were measured in homogenates of polyp tissue obtained from patients with CRSwNP. The relationship of these factors and their expression in groups classified according to tissue IL-5 and IL-17 concentrations were analyzed. Cross-regulation of T H 2 and T H 17 cytokines and the effects of dexamethasone treatment were studied in dispersed nasal polyp cells. Associations between T H 2- and T H 17 related factors and comorbid atopic status and asthma, disease recurrence, and edema scores were also explored. Results Four CRSwNP groups were classified based on expression or nonexpression of mutually exclusive T H 2- and T H 17-related factors. The T H 2 cytokines IL-4 and IL-13 inhibited expression of T H 17-related factors, whereas the T H 17 cytokines IL-17 and TGF-β1 enhanced expression of T H 2-related factors. Dexamethasone treatment inhibited both the T H 2 and T H 17 pathways. A patient's atopic status was related to their T H 2 immune response. Edema scores were positively correlated with the T H 2 pathway and negatively correlated with the T H 17 pathway. Conclusion The T H 2 and T H 17 pathways are mutually exclusive and regulate each other, favoring the development of a T H 2 immune response in Chinese patients with CRSwNP.

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    “serologic anti-microbial antibodies are common in patients with CD and are associated with and predictive of intestinal strictures152,153”

    From Fibrosis: from mechanisms to medicines (2020) · cites this paper as [153]

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Metadata

Authors
Wang, M., Zhang, N., Zheng, M., Li, Y., Meng, L., Ruan, Y., Han, J., Zhao, N., Wang, X., Zhang, L., & Bachert, C.
Affiliations
  • Beijing Tongren Hospital (CN)
  • Ghent University Hospital (BE)
  • Capital Medical University (CN)
  • Karolinska University Hospital (SE)
Corresponding author
  • Wang, Xiangdong
  • Zhang, Luo
ORCID
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2019-11
Volume
144
Issue
5
Pages
1254-1264
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2019.06.023
OpenAlex
W2954471812
Cited by
61
References
41
Citations by year
2026: 5 · 2025: 8 · 2024: 11 · 2023: 9 · 2022: 7 · 2021: 10 · 2020: 10 · 2019: 1
FWCI
5.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Allergy and Clinical Immunology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion)
Funders
  • National Key R&D Program of China (2016YFC20160905200)
  • Program for the Changjiang scholars and Innovative Research Team (IRT13082)
  • National Natural Science Foundation of China (81420108009, 81630023, 81570893, 81570894)
  • Beijing Municipal Administration of Hospitals' Mission Plan (SML20150203)
  • Beijing Advanced Innovation Center for Food Nutrition and Human Health
  • Beijing Technology and Business University (20181045)
  • Capital Health Research and Development of Special (2014-4-1092)
  • Beijing Natural Science Foundation (7162042, 7172054)
Topics
  • Health Sciences › Medicine › Otorhinolaryngology › Sinusitis and nasal conditions
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords
chronic rhinosinusitis with nasal polyps, Th2 pathway, Th17 pathway, IL-4, IL-13, IL-17, TGF-β1, dexamethasone, nasal polyp tissue, atopy, asthma comorbidity, nasal edema, recurrence, Chinese patients
MeSH terms
Adult, Cells, Cultured, Chronic Disease, Female, Humans, Male, Middle Aged, Nasal Polyps, Rhinitis, Sinusitis, Interleukin-5, Th2 Cells, Paracrine Communication, Interleukin-17, Th17 Cells

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