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The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan

Open access
Li, Xiaochen, Xu, Shuyun, Yu, Muqing, Wang, Ke, Tao, Yu, Zhou, Ying, Shi, Jing, Zhou, Min, Wu, Bo, Yang, Zhenyu, Zhang, Cong, Yue, Junqing, Zhang, Zhiguo, Renz, Harald, Liu, Xiansheng, Xie, Jungang, Xie, Min, Zhao, Jianping·2020·Journal of Allergy and Clinical Immunology
DOI 10.1016/j.jaci.2020.04.006
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Abstract

Background In December 2019, the coronavirus disease 2019 (COVID-19) outbreak occurred in Wuhan. Data on the clinical characteristics and outcomes of patients with severe COVID-19 are limited. Objective We sought to evaluate the severity on admission, complications, treatment, and outcomes of patients with COVID-19. Methods Patients with COVID-19 admitted to Tongji Hospital from January 26, 2020, to February 5, 2020, were retrospectively enrolled and followed-up until March 3, 2020. Potential risk factors for severe COVID-19 were analyzed by a multivariable binary logistic model. Cox proportional hazard regression model was used for survival analysis in severe patients. Results We identified 269 (49.1%) of 548 patients as severe cases on admission. Older age, underlying hypertension, high cytokine levels (IL-2R, IL-6, IL-10, and TNF-α), and high lactate dehydrogenase level were significantly associated with severe COVID-19 on admission. The prevalence of asthma in patients with COVID-19 was 0.9%, markedly lower than that in the adult population of Wuhan. The estimated mortality was 1.1% in nonsevere patients and 32.5% in severe cases during the average 32 days of follow-up period. Survival analysis revealed that male sex, older age, leukocytosis, high lactate dehydrogenase level, cardiac injury, hyperglycemia, and high-dose corticosteroid use were associated with death in patients with severe COVID-19. Conclusions Patients with older age, hypertension, and high lactate dehydrogenase level need careful observation and early intervention to prevent the potential development of severe COVID-19. Severe male patients with heart injury, hyperglycemia, and high-dose corticosteroid use may have a high risk of death.

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Metadata

Authors
Li, X., Xu, S., Yu, M., Wang, K., Tao, Y., Zhou, Y., Shi, J., Zhou, M., Wu, B., Yang, Z., Zhang, C., Yue, J., Zhang, Z., Renz, H., Liu, X., Xie, J., Xie, M., & Zhao, J.
Venue
Journal of Allergy and Clinical Immunology
Publisher
Elsevier BV
Published
2020-07
Volume
146
Issue
1
Pages
110-118
ISSN
0091-6749 (ISSN-L)
DOI
10.1016/j.jaci.2020.04.006
OpenAlex
W3015696390
Cited by
2,219
References
10
FWCI
61.44
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. https://app.cochat.ai/papers/10.1016/j.jaci.2020.04.006
The paper
Li, X., Xu, S., Yu, M., Wang, K., Tao, Y., Zhou, Y., Shi, J., Zhou, M., Wu, B., Yang, Z., Zhang, C., Yue, J., Zhang, Z., Renz, H., Liu, X., Xie, J., Xie, M., & Zhao, J. (2020). Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2020.04.006

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.