The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Environmental factors in epithelial barrier dysfunction
Abstract
The main interfaces controlling and attempting to homeostatically balance communications between the host and the environment are the epithelial barriers of the skin, gastrointestinal system, and airways. The epithelial barrier constitutes the first line of physical, chemical, and immunologic defenses and provides a protective wall against environmental factors. Following the industrial revolution in the 19th century, urbanization and socioeconomic development have led to an increase in energy consumption, and waste discharge, leading to increased exposure to air pollution and chemical hazards. Particularly after the 1960s, biological and chemical insults from the surrounding environment-the exposome-have been disrupting the physical integrity of the barrier by degrading the intercellular barrier proteins at tight and adherens junctions, triggering epithelial alarmin cytokine responses such as IL-25, IL-33, and thymic stromal lymphopoietin, and increasing the epithelial barrier permeability. A typical type 2 immune response develops in affected organs in asthma, rhinitis, chronic rhinosinusitis, eosinophilic esophagitis, food allergy, and atopic dermatitis. The aim of this article was to discuss the effects of environmental factors such as protease enzymes of allergens, detergents, tobacco, ozone, particulate matter, diesel exhaust, nanoparticles, and microplastic on the integrity of the epithelial barriers in the context of epithelial barrier hypothesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2015) · Springer eBooks · doi:10.1007/978-3-319-16510-3 · Cited by 3,502
Plastic and Human Health: A Micro Issue?
Wright, S. L., & Kelly, F. J. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b00423 · Cited by 3,413
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature Reviews Immunology · doi:10.1038/nri3608 · Cited by 3,173
Atmospheric transport and deposition of microplastics in a remote mountain catchment
Allen, S., Allen, D., Phoenix, V. R., Le Roux, G., Durántez Jiménez, P., Simonneau, A., Binet, S., & Galop, D. (2019) · Nature Geoscience · doi:10.1038/s41561-019-0335-5 · Cited by 2,319
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
Chassaing, B., Koren, O., Goodrich, J. K., Poole, A. C., Srinivasan, S., Ley, R. E., & Gewirtz, A. T. (2015) · Nature · doi:10.1038/nature14232 · Cited by 2,055
Intestinal barrier function: molecular regulation and disease pathogenesis
Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775
Airway Mucus Function and Dysfunction
Fahy, J. V., & Dickey, B. F. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0910061 · Cited by 1,722
Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Filaggrin Mutations Associated with Skin and Allergic Diseases
Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217
Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice
Jin, Y., Lu, L., Tu, W., Luo, T., & Fu, Z. (2019) · Science of The Total Environment · doi:10.1016/j.scitotenv.2018.08.353 · Cited by 1,100
Cited by
Microplastics and Oxidative Stress—Current Problems and Prospects
Kadac-Czapska, K., Ośko, J., Knez, E., & Grembecka, M. (2024) · Antioxidants · doi:10.3390/antiox13050579 · Cited by 341
Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns
Gargano, D., Appanna, R., Santonicola, A., De Bartolomeis, F., Stellato, C., Cianferoni, A., Casolaro, V., & Iovino, P. (2021) · Nutrients · doi:10.3390/nu13051638 · Cited by 169
Dysregulation of the epithelial barrier by environmental and other exogenous factors
Mitamura, Y., Ogulur, I., Pat, Y., Rinaldi, A. O., Ardicli, O., Cevhertas, L., Brüggen, M., Traidl‐Hoffmann, C., Akdis, M., & Akdis, C. A. (2021) · Contact Dermatitis · doi:10.1111/cod.13959 · Cited by 85
Self-citationThe role of the environment in allergic skin disease
Faraz, K., Seely, M., & Marano, A. L. (2024) · Current Allergy and Asthma Reports · doi:10.1007/s11882-024-01147-9 · Cited by 20
(2022) · Asian Pacific Journal of Allergy and Immunology · doi:10.12932/ap-060922-1448 · Cited by 12
Metadata
- Authors
- Celebi Sözener, Z., Cevhertas, L., Nadeau, K., Akdis, M., & Akdis, C. A.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 145
- Issue
- 6
- Pages
- 1517-1528
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W3033954215
- Cited by
- 384
- References
- 118
- FWCI
- 20.99
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Environmental factors in epithelial barrier dysfunction. https://app.cochat.ai/papers/10.1016/j.jaci.2020.04.024
- The paper
- Celebi Sözener, Z., Cevhertas, L., Nadeau, K., Akdis, M., & Akdis, C. A. (2020). Environmental factors in epithelial barrier dysfunction. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2020.04.024
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
