Psoriasis-associated impairment of CCL27/CCR10-derived regulation leads to IL-17A/IL-22-producing skin T-cell overactivation
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Over-active IL-17A+ T cell responses also increase skin inflammation in CCR10EGFP/EGFP mice in an imiquimod-induced model of psoriasis.
“Consistent with this finding, we previously found that over-active IL-17A+ T cell responses also increase skin inflammation in CCR10EGFP/EGFP mice in an imiquimod-induced model of psoriasis.44”
From Skin-resident T cells play an important role in controlling skin colonization of Candidozyma (Candida) auris (2026) · cites this paper as [44]
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Cites
Jin, Y., Xia, M., Sun, A., Saylor, C. M., & Xiong, N. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001612 · Cited by 74 · see citing works
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Research works printed but not linked: 8
- [1]Xiong N, Fu Y, Hu S, Xia M, Yang J. CCR10 and its ligands in regulation of epithelial immunity and diseases. Protein Cell. 2012; 3(8): 571– 80. 22684736 PMC4430102
- [2]Homey B, Alenius H, Muller A, Soto H, Bowman EP, Yuan W, CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med. 2002; 8(2): 157– 65. 11821900
- [3]Gudjonsson JE, Ding J, Johnston A, Tejasvi T, Guzman AM, Nair RP, Assessment of the psoriatic transcriptome in a large sample: additional regulated genes and comparisons with in vitro models. J Invest Dermatol. 2010; 130(7): 1829– 40. 20220767 PMC3128718
- [4]Riis JL, Johansen C, Vestergaard C, Bech R, Kragballe K, Iversen L. Kinetics and differential expression of the skin-related chemokines CCL27 and CCL17 in psoriasis, atopic dermatitis and allergic contact dermatitis. Exp Dermatol. 2011; 20(10): 789– 94. 21707761
- [6]Xia M, Hu S, Fu Y, Jin W, Yi Q, Matsui Y, CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin. J Allergy Clin Immunol. 2014; 134(3): 634– 44 e10. 24767879 PMC4149943
- [7]Yang J, Hu S, Zhao L, Kaplan DH, Perdew GH, Xiong N. Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation. Nat Immunol. 2016; 17(1): 48– 56. 26523865 PMC4838393
- [8]van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol. 2009; 182(9): 5836– 45. 19380832
- [9]Coyne J, Davis B, Kauffman D, Zhao N, Wang Y. Polymer Microneedle Mediated Local Aptamer Delivery for Blocking the Function of Vascular Endothelial Growth Factor. ACS Biomater Sci Eng. 2017; 3(12): 3395– 403. 29707631 PMC5912260
Cited by
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Xie, J., Yan, L., Kadosh, D., & Xiong, N. (2026) · iScience · doi:10.1016/j.isci.2026.115862 · Cited by 1 · see citing works
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- Authors
- Li, C., Xu, M., Coyne, J., Wang, W.-B., Davila, M. L., Wang, Y., & Xiong, N.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Wang, Yong
- Xiong, Na
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 147
- Issue
- 2
- Pages
- 759-763.e9
- ISSN
- 0091-6749 (ISSN-L)
- PMC
- PMC7726097
- OpenAlex
- W3035574908
- Cited by
- 30
- References
- 1
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 7
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (AR064831, R01AR070887, R01AR073364)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- psoriasis, CCL27, CCR10, IL-17A, IL-22, immune regulation, skin inflammation, chemokine signaling
- MeSH terms
- Interleukin-22, Animals, Interleukins, Lymphocyte Activation, Psoriasis, Skin, T-Lymphocytes, Interleukin-17, Mice, Chemokine CCL27, Receptors, CCR10
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