The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Advances in asthma: New understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management
Abstract
The last two years yielded a proliferation of high-quality asthma research. These include new understandings of the incidence and natural history of asthma, findings on the effects of exposure to air pollution, allergens, and intake of acetaminophen, soy isoflavones, polyunsaturated fatty acids, and exposure to microbial products. The past two years have benefitted from great strides in determining potential mechanisms of asthma development and asthma exacerbations. These novel understandings led to identification and development of exciting new avenues for potential therapeutic intervention. Finally, there has been significant progress made in the development of tools to facilitate the diagnosis of asthma and measurement of airway physiology and in precision diagnostic approaches. Asthma guidelines were updated and new insights into the pharmacologic management of patients, including biologics, were reported. We review the most notable advances in the natural history of asthma, risk factors for the development asthma, underlying mechanisms, diagnostic approaches, and treatments. While greater knowledge of the mechanisms underlying responses and nonresponses to novel therapeutics and across asthma phenotypes would be beneficial, the progress over just the past two years has been immense and impactful.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma
Menzies-Gow, A., Corren, J., Bourdin, A., Chupp, G., Israel, E., Wechsler, M. E., Brightling, C. E., Griffiths, J. M., Hellqvist, Å., Bowen, K., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2034975 · Cited by 1,056
Innate lymphoid cells: A new paradigm in immunology
Eberl, G., Colonna, M., Di Santo, J. P., & McKenzie, A. N. J. (2015) · Science · doi:10.1126/science.aaa6566 · Cited by 878
Cloutier, M. M., Baptist, A. P., Blake, K. V., Brooks, E. G., Bryant-Stephens, T., DiMango, E., Dixon, A. E., Elward, K. S., Hartert, T., Krishnan, J. A., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.10.003 · Cited by 854
Zhu, Z., Guo, Y., Shi, H., Liu, C.-L., Panganiban, R. A., Chung, W., O'Connor, L. J., Himes, B. E., Gazal, S., Hasegawa, K., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.09.035 · Cited by 362
Pividori, M., Schoettler, N., Nicolae, D. L., Ober, C., & Im, H. K. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(19)30055-4 · Cited by 345
Busse, W. W., Bleecker, E. R., FitzGerald, J. M., Ferguson, G. T., Barker, P., Sproule, S., Olsson, R. F., Martin, U. J., Goldman, M., Yañez, A., et al. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30406-5 · Cited by 314
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment
Persson, E. K., Verstraete, K., Heyndrickx, I., Gevaert, E., Aegerter, H., Percier, J.-M., Deswarte, K., Verschueren, K. H. G., Dansercoer, A., Gras, D., et al. (2019) · Science · doi:10.1126/science.aaw4295 · Cited by 310
Prevalence and characterization of asthma in hospitalized and nonhospitalized patients with COVID-19
Chhiba, K. D., Patel, G. B., Vu, T. H. T., Chen, M. M., Guo, A., Kudlaty, E., Mai, Q., Yeh, C., Muhammad, L. N., Harris, K. E., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.06.010 · Cited by 308
Khatri, S., Moore, W., Gibson, P. G., Leigh, R., Bourdin, A., Maspero, J., Barros, M., Buhl, R., Howarth, P., Albers, F. C., et al. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.09.033 · Cited by 304
Patrick, D. M., Sbihi, H., Dai, D. L. Y., Al Mamun, A., Rasali, D., Rose, C., Marra, F., Boutin, R. C. T., Petersen, C., Stiemsma, L. T., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30052-7 · Cited by 250
Metadata
- Authors
- Miller, R. L., Grayson, M. H., & Strothman, K.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2021-12
- Volume
- 148
- Issue
- 6
- Pages
- 1430-1441
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W3205669838
- Cited by
- 365
- References
- 78
- FWCI
- 20.62
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Advances in asthma: New understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management. https://app.cochat.ai/papers/10.1016/j.jaci.2021.10.001
- The paper
- Miller, R. L., Grayson, M. H., & Strothman, K. (2021). Advances in asthma: New understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2021.10.001
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
