The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Protein crystallization promotes type 2 immunity and is reversible by antibody treatment
Open accessAbstract
A crystal-clear ingredient for allergy?: Charcot-Leyden crystals (CLCs) are formed from the eosinophil granule protein galectin-10 (Gal10) and found in severe eosinophil-associated diseases like asthma and chronic rhinosinusitis. Whether CLCs actively contribute to disease pathogenesis is unknown. Persson et al. found that lab-grown Gal10 crystals are biosimilar to CLCs (see the Perspective by Allen and Sutherland). When given to mice, the crystals acted as a type 2 adjuvant, mimicking many of the features of human asthma. In contrast, a Gal10 mutein unable to crystallize had no effect. Antibodies against epitopes crucial for Gal10 autocrystallization could dissolve both in vitro–generated Gal10 crystals and patient-derived CLCs. Furthermore, these anti-Gal10 antibodies reversed the effects of Gal10 crystals in a humanized mouse model of asthma, suggesting a potential therapeutic approach for crystallopathies more broadly. Science , this issue p. eaaw4295 ; see also p. 738
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Self-citationLinking Crystallographic Model and Data Quality
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Miller, R. L., Grayson, M. H., & Strothman, K. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.10.001 · Cited by 365
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Metadata
- Authors
- Persson, E. K., Verstraete, K., Heyndrickx, I., Gevaert, E., Aegerter, H., Percier, J.-M., Deswarte, K., Verschueren, K. H. G., Dansercoer, A., Gras, D., Chanez, P., Bachert, C., Gonçalves, A., Van Gorp, H., De Haard, H., Blanchetot, C., Saunders, M., Hammad, H., Savvides, S. N., & Lambrecht, B. N.
- Venue
- Science
- Published
- 2019-05-24
- Volume
- 364
- Issue
- 6442
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2946429186
- Cited by
- 310
- References
- 10
- FWCI
- 22.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Persson, E. K., Verstraete, K., Heyndrickx, I., Gevaert, E., Aegerter, H., Percier, J.-M., Deswarte, K., Verschueren, K. H. G., Dansercoer, A., Gras, D., Chanez, P., Bachert, C., Gonçalves, A., Van Gorp, H., De Haard, H., Blanchetot, C., Saunders, M., Hammad, H., Savvides, S. N., & Lambrecht, B. N. (2019). Protein crystallization promotes type 2 immunity and is reversible by antibody treatment. Science. https://doi.org/10.1126/science.aaw4295
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