Angiopoietin-like protein 4: a therapeutic target for triglycerides and coronary disease?

Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene

Kersten, S., Mandard, S., Tan, N. S., Escher, P., METZGER, D., Chambon, P., Gonzalez, F. J., Desvergne, B., & Wahli, W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004029200 · Cited by 560 · see citing works

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Romeo, S., Pennacchio, L. A., Fu, Y., Boerwinkle, E., Tybjaerg-Hansen, A., Hobbs, H. H., & Cohen, J. C. (2007) · Nature Genetics · doi:10.1038/ng1984 · Cited by 511 · see citing works

Inactivating Variants in <i>ANGPTL4</i> and Risk of Coronary Artery Disease

Dewey, F. E., Gusarova, V., O’Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C. V., Habegger, L., Buckler, D., Lai, K.-M. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1510926 · Cited by 497 · see citing works

Coding Variation in <i>ANGPTL4,</i> <i>LPL,</i> and <i>SVEP1</i> and the Risk of Coronary Disease

Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia Investigators (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1507652 · Cited by 493 · see citing works

Transgenic Angiopoietin-Like (Angptl)4 Overexpression and Targeted Disruption of Angptl4 and Angptl3: Regulation of Triglyceride Metabolism

Köster, A., Chao, Y. B., Mosior, M., Ford, A., Gonzalez-DeWhitt, P. A., Hale, J. E., Li, D., Qiu, Y., Fraser, C. C., Yang, D. D., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0476 · Cited by 427 · see citing works

Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue

Sukonina, V., Lõokene, A., Olivecrona, T., & Olivecrona, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604026103 · Cited by 402 · see citing works

Peroxisome Proliferator-Activated Receptor γ Target Gene Encoding a Novel Angiopoietin-Related Protein Associated with Adipose Differentiation

Yoon, J. C., Chickering, T. W., Rosen, E. D., Dussault, B. J., Qin, Y., Soukas, A. A., Friedman, J. M., Holmes, W. E., & Spiegelman, B. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5343-5349.2000 · Cited by 399 · see citing works

Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

Xu, A., Lam, M. C., Chan, K. W., Wang, Y., Zhang, J., Hoo, R. L. C., Xu, J. Y., Chen, B., Chow, W.-S., Tso, A. W. K., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408452102 · Cited by 315 · see citing works

Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

Peloso, G. M., Auer, P. L., Bis, J. C., Voorman, A., Morrison, A. C., Stitziel, N. O., Brody, J. A., Khetarpal, S. A., Crosby, J. R., Fornage, M., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.01.009 · Cited by 309 · see citing works

ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters

Huang, R.-L., Teo, Z., Chong, H. C., Zhu, P., Tan, M., Tan, C. K., Lam, C. R. I., Sng, M. K., Leong, D. T., Tan, S., et al. (2011) · Blood · doi:10.1182/blood-2011-01-328716 · Cited by 284 · see citing works

Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis

Kim, I., Kim, H.-G., Kim, H., Kim, H.-H., Park, S. K., Uhm, C.-S., Lee, Z. H., & Koh, G. Y. (2000) · Biochemical Journal · doi:10.1042/bj3460603 · Cited by 284 · see citing works

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

Lichtenstein, L., Mattijssen, F., de Wit, N. J. W., Georgiadi, A., Hooiveld, G. J. E. J., van der Meer, R., He, Y., Qi, L., Koster, A. M., Tamsma, J. T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.002 · Cited by 269 · see citing works

Angptl4 Upregulates Cholesterol Synthesis in Liver via Inhibition of LPL- and HL-Dependent Hepatic Cholesterol Uptake

Lichtenstein, L., Berbée, J. F. P., van Dijk, S. J., van Dijk, K. W., Bensadoun, A., Kema, I. P., Voshol, P. J., Müller, M. M., Rensen, P. C. N., & Kersten, S. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151894 · Cited by 196 · see citing works

Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice

Desai, U. S., Lee, E.-C., Chung, K., Gao, C., Gay, J. P., Key, B., Hansen, G. M., Machajewski, D., Platt, K. A., Sands, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705041104 · Cited by 192 · see citing works

Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function

Wu, Y., Romeo, S., Chang, S., Grishin, N. V., Hobbs, H. H., & Cohen, J. C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900553200 · Cited by 140 · see citing works

ANGPTL4 Induction by Prostaglandin E2 under Hypoxic Conditions Promotes Colorectal Cancer Progression

Kim, S.-H., Park, Y., Kim, S., Lee, J., Wang, D., & DuBois, R. N. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1262 · Cited by 131 · see citing works

Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4

Ge, H., Yang, G., Yu, X., Pourbahrami, T., & Li, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m400138-jlr200 · Cited by 115 · see citing works

Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample

Robciuc, M. R., Tahvanainen, E., Jauhiainen, M., & Ehnholm, C. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m002618 · Cited by 107 · see citing works

ANGPTL4 E40K and T266M

Talmud, P. J., Smart, M., Presswood, E., Cooper, J. A., Nicaud, V., Drenos, F., Palmen, J., Marmot, M. G., Boekholdt, S. M., Wareham, N. J., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.176917 · Cited by 103 · see citing works

Overexpression of Angiopoietin-Like Protein 4 Protects Against Atherosclerosis Development

Georgiadi, A., Wang, Y., Stienstra, R., Tjeerdema, N., Janssen, A. W. F., Stalenhoef, A. F. H., van der Vliet, J. A., Roos, A., Tamsma, J. T., Smit, J. W. A., et al. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.301698 · Cited by 102 · see citing works

Angptl4 serves as an endogenous inhibitor of intestinal lipid digestion

Mattijssen, F., Alex, S., Swarts, H. J., Groen, A. K., van Schothorst, E. M., & Kersten, S. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2013.11.004 · Cited by 88 · see citing works

Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis

Adachi, H., Fujiwara, Y., Kondo, T., Nishikawa, T., Ogawa, R., Matsumura, T., Ishii, N., Nagai, R., Miyata, K., Tabata, M., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.12.018 · Cited by 80 · see citing works

Differential Association of Plasma Angiopoietin-Like Proteins 3 and 4 With Lipid and Metabolic Traits

Mehta, N., Qamar, A., Qu, L., Qasim, A., Mehta, N. N., Reilly, M. P., & Rader, D. J. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.113.302802 · Cited by 80 · see citing works

The Relationship Between Plasma Angiopoietin-like Protein 4 Levels, Angiopoietin-like Protein 4 Genotype, and Coronary Heart Disease Risk

Smart, M., Robciuc, M. R., Cooper, J. A., Jauhiainen, M., Meena Kumari, B., Mika Kivimaki, B., Khaw, K., Boekholdt, S. M., Wareham, N. J., Gaunt, T. R., et al. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.212209 · Cited by 75 · see citing works

Variation in ANGPTL4 and risk of coronary heart disease: the Atherosclerosis Risk in Communities Study

Folsom, A. R., Peacock, J. M., Demerath, E. W., & Boerwinkle, E. (2008) · Metabolism · doi:10.1016/j.metabol.2008.06.016 · Cited by 73 · see citing works

Fatty Acids and Hypoxia Stimulate the Expression and Secretion of the Adipokine ANGPTL4 (Angiopoietin-Like Protein 4/ Fasting-Induced Adipose Factor) by Human Adipocytes

González‐Muniesa, P., de Oliveira, C., de Heredia, F. P., Thompson, M. P., & Trayhurn, P. (2011) · Lifestyle Genomics · doi:10.1159/000327774 · Cited by 66 · see citing works

Angiopoietin-like protein 4 significantly predicts future cardiovascular events in coronary patients

Muendlein, A., Saely, C. H., Leiherer, A., Fraunberger, P., Kinz, E., Rein, P., Vonbank, A., Zanolin, D., Malin, C., & Drexel, H. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.028 · Cited by 45 · see citing works

ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial

Study, T. L. A., Smart, M., Kelley-Hedgepeth, A., Montefusco, M. C., Cooper, J. A., Kopin, A. S., McCaffery, J. M., Balasubramanyam, A., Pownall, H. J., Nathan, D. M., et al. (2011) · BMC Medical Genetics · doi:10.1186/1471-2350-12-89 · Cited by 37 · see citing works

Longitudinal Changes in Triglycerides According to ANGPTL4[E40K] Genotype and Longitudinal Body Weight Change in the Atherosclerosis Risk in Communities Study

Nettleton, J. A., Volcik, K. A., Demerath, E. W., Boerwinkle, E., & Folsom, A. R. (2008) · Annals of Epidemiology · doi:10.1016/j.annepidem.2008.07.004 · Cited by 13 · see citing works

Clinical review on triglycerides

Laufs, U., Parhofer, K. G., Ginsberg, H. N., & Hegele, R. A. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz785 · Cited by 544 · see citing works

Lipid-Lowering Agents: Targets Beyond PCSK9

Hegele, R. A., & Tsimikas, S. (2019) · Circulation Research · doi:10.1161/circresaha.118.313171 · Cited by 171 · see citing works

Gut Microbiota Is a Major Contributor to Adiposity in Pigs

Yang, H., Xiang, Y., Robinson, K., Wang, J., Zhang, G., Zhao, J., & Xiao, Y. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03045 · Cited by 96 · see citing works

Targeted pharmacotherapy for ischemia reperfusion injury in acute myocardial infarction

Rout, A., Tantry, U. S., Novaković, M., Sukhi, A., & Gurbel, P. A. (2020) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2020.1787987 · Cited by 74 · see citing works

Gut Microbiota Influence Lipid Metabolism of Skeletal Muscle in Pigs

Wu, C., Lyu, W., Hong, Q., Zhang, X., Yang, H., & Xiao, Y. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.675445 · Cited by 65 · see citing works

Biomarkers of dysfunctional visceral fat

Gugliucci, A. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.03.001 · Cited by 58 · see citing works

ANGPTL4 regulate glutamine metabolism and fatty acid oxidation in nonsmall cell lung cancer cells

Song, X., Nai‐dong, W., Jin‐Xiang, Y., Long, T., Lu, X., Hong, G., Jie‐Cheng, Y., & Fei, Z. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16879 · Cited by 49 · see citing works

Engineered exosomes as a prospective therapy for diabetic foot ulcers

Guo, L., Xiao, D., Xing, H., Yang, G., & Yang, X. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae023 · Cited by 39 · see citing works

Novel aspects of PCSK9 and lipoprotein receptors in renal disease-related dyslipidemia

Shrestha, P., van de Sluis, B., Dullaart, R. P. F., & van den Born, J. (2018) · Cellular Signalling · doi:10.1016/j.cellsig.2018.12.001 · Cited by 33 · see citing works

Cardio- and Neurometabolic Adipobiology: Consequences and Implications for Therapy

Fröhlich, J., Chaldakov, G. N., & Vinciguerra, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084137 · Cited by 26 · see citing works

Journal of Diabetes & Metabolism

(2019) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156 · Cited by 22 · see citing works

ANGPTL4 gene E40K variation protects against obesity‐associated dyslipidemia in participants with obesity

Bailetti, D., Bertoccini, L., Mancina, R. M., Barchetta, I., Capoccia, D., Cossu, E., Pujia, A., Lenzi, A., Leonetti, F., Cavallo, M. G., et al. (2018) · Obesity Science & Practice · doi:10.1002/osp4.311 · Cited by 19 · see citing works

ANGPTL4 Expression Is Increased in Epicardial Adipose Tissue of Patients with Coronary Artery Disease

Katanasaka, Y., Saito, A., Sunagawa, Y., Sari, N., Funamoto, M., Shimizu, S., Shimizu, K., Akimoto, T., Ueki, C., Kitano, M., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092449 · Cited by 18 · see citing works

Deficiency of angiopoietin‐like 4 enhances CD8 + T cell bioactivity via metabolic reprogramming for impairing tumour progression

Ding, S., Lin, Z., Zhang, X., Jia, X., Li, H., Fu, Y., Wang, X., Zhu, G., Lu, G., Xiao, W., et al. (2023) · Immunology · doi:10.1111/imm.13650 · Cited by 16 · see citing works

Angiopoietin‐2 and angiopoietin‐like 4 protein provide prognostic information in patients with suspected acute coronary syndrome

Aarsetoey, R., Ueland, T., Aukrust, P., Michelsen, A. E., de la Fuente, R. L., Pönitz, V., Brügger‐Andersen, T., Grundt, H., Staines, H., & Nilsen, D. W. T. (2021) · Journal of Internal Medicine · doi:10.1111/joim.13339 · Cited by 15 · see citing works

Brain-acting hepatokines: its impact on energy balance and metabolism

Giovanini, L., Wanionok, N. E., Perelló, M., & Cornejo, M. P. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1589110 · Cited by 14 · see citing works

When to lower triglycerides?

Ganda, O. P. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000694 · Cited by 11 · see citing works

Longitudinal analysis of genetic and environmental interplay in human metabolic profiles and the implication for metabolic health

Wang, J., Zenere, A., Wang, X.-Y., Bergström, G., Edfors, F., Uhlén, M., & Zhong, W. (2024) · Genome Medicine · doi:10.1186/s13073-025-01492-y · Cited by 9 · see citing works

Angiopoietin-Like Protein 4 May Be an Interplay Between Serum Uric Acid and Triglyceride-Rich Lipoprotein Cholesterol

Peng, Y., Hu, D., Luo, Q., & Peng, D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.863687 · Cited by 6 · see citing works

Hypocholesterolemia and dysregulated production of angiopoietin-like proteins in sickle cell anemia patients

Vendrame, F., Olops, L., Saad, S. T. O., Costa, F. F., & Fertrin, K. Y. (2019) · Cytokine · doi:10.1016/j.cyto.2019.04.014 · Cited by 6 · see citing works

The Effect of Protease-Activated Receptor-1 (PAR-1) Inhibition on Endothelial-Related Biomarkers in Patients with Coronary Artery Disease

Nilsen, D. W. T., Røysland, M., Ueland, T., Aukrust, P., Michelsen, A. E., Staines, H., Barvik, S., Kontny, F. P., Nordrehaug, J. E., & Bonarjee, V. (2022) · Thrombosis and Haemostasis · doi:10.1055/s-0042-1760256 · Cited by 5 · see citing works

Assessment of Two Potential Probiotic Strains As Anti-Obesity Supplements Under High-Fat Feeding Conditions

Alsuhaymi, N., Darwish, A. M., & Khattab, A. E.-N. A. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09912-w · Cited by 5 · see citing works

Beyond Statins: Who and When to Prescribe?

Ganda, O. P. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1087-0 · Cited by 5 · see citing works

Elevated Plasma Angiopoietin-like 4 Protein Levels in Adult Patients with Dengue

Khaing, W., Lau, S. H., Thein, T.-L., Tan, N. S., Alonso, S., Vasoo, S. S., Chia, P. Y., Lye, D. C., Leo, Y. S., & Chow, V. T. K. (2025) · Viruses · doi:10.3390/v17020226 · Cited by 4 · see citing works

Serum ANGPTL4 and SIRT1 factor levels and the Carotid Atherosclerotic plaque stability relationship analysis

Chen, J., Li, J., Wang, Y., Zhang, Z., Yang, H., Li, Z., Wang, T., Peng, T., Mo, X., & Xu, F. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.9.9 · Cited by 4 · see citing works

Antibodies to cyclic citrullinated peptide and angiopoietin-like protein type 4 as markers of immune inflammation and osteoporotic processes in rheumatoid arthritis patients

Osmanova, G. Y., Андреевич, А. В., Александров, А. В., Shilova, L. N., Черкесова, Е. Г., Владимировна, А. Н., & Zborovskaya, I. A. (2023) · Medical Immunology (Russia) · doi:10.15789/1563-0625-atc-2862 · Cited by 3 · see citing works

Avaliação do papel das lipoproteínas nas doenças falciformes

Vendrame, F. (2018) · doi:10.47749/t/unicamp.2018.1063280

ANGPTL4 supports glutamine metabolism and promotes fatty acid oxidation in nonsmall cell lung cancer cellsPreprint

Song, X. M., Nai-Dong, W., Yan, J.-X., Long, T., Lu, X., Gao, H. Z., Jie‐Cheng, Y., & Zhang, F. (2020) · Research Square · doi:10.21203/rs.3.rs-106033/v1

Anagrelide alleviates myocardial ischaemia–reperfusion injury by inhibiting reticulated platelets

Zhang, P., Xu, H., Zhao, X., Qi, Z., Yao, Y., Zhao, Q., Sun, P., Fan, B., Wu, H., & Ge, J. (2023) · Medical Hypotheses · doi:10.1016/j.mehy.2023.111193

Fucoidan from Fucus vesiculosus Protects Retinal Pigment Epithelium from Lipid-Induced Damage Related to AMD

Hacker, F., Roider, J. B., Klettner, A., & Dörschmann, P. (2026) · Marine Drugs · doi:10.3390/md24020064

Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism

Kersten, S. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100150 · Cited by 146 · see citing works

Angiopoietin-like proteins as therapeutic targets for cardiovascular disease: focus on lipid disorders

Morelli, M. B., Chavez, C., & Santulli, G. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1707806 · Cited by 64 · see citing works

Research Progress on the Involvement of ANGPTL4 and Loss-of-Function Variants in Lipid Metabolism and Coronary Heart Disease: Is the “Prime Time” of ANGPTL4-Targeted Therapy for Coronary Heart Disease Approaching?

Yang, H. J., Xiao, L., & Xu, D. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07001-0 · Cited by 26 · see citing works

New insights into angiopoietin-like proteins in lipid metabolism and cardiovascular disease risk

Kersten, S. (2019) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000600 · Cited by 94 · see citing works

Impacts of angiopoietin-like proteins on lipoprotein metabolism and cardiovascular events

Miida, T., & Hirayama, S. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328333269e · Cited by 59 · see citing works