Cited by 88Lipid metabolism and disordersLipid metabolism and biosynthesisFatty Acid Research and Health

Angptl4 serves as an endogenous inhibitor of intestinal lipid digestion

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Mattijssen, Frits, Alex, Sheril, Swarts, Hans J., Groen, Albert K., van Schothorst, Evert M., Kersten, Sander·2014·Molecular Metabolism

Abstract

Dietary triglycerides are hydrolyzed in the small intestine principally by pancreatic lipase. Following uptake by enterocytes and secretion as chylomicrons, dietary lipids are cleared from the bloodstream via lipoprotein lipase. Whereas lipoprotein lipase is inhibited by several proteins including Angiopoietin-like 4 (Angptl4), no endogenous regulator of pancreatic lipase has yet been identified. Here we present evidence that Angptl4 is an endogenous inhibitor of dietary lipid digestion. Angptl4-/- mice were heavier compared to their wild-type counterparts without any difference in food intake, energy expenditure or locomotor activity. However, Angptl4-/- mice showed decreased lipid content in the stools and increased accumulation of dietary triglycerides in the small intestine, which coincided with elevated luminal lipase activity in Angptl4-/- mice. Furthermore, recombinant Angptl4 reduced the activity of pancreatic lipase as well as the lipase activity in human ileostomy output. In conclusion, our data suggest that Angptl4 is an endogenous inhibitor of intestinal lipase activity.

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Crossref · 10.1016/j.molmet.2013.11.004

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Authors
Mattijssen, F., Alex, S., Swarts, H. J., Groen, A. K., van Schothorst, E. M., & Kersten, S.
Affiliations
  • Wageningen University & Research (NL)
  • University Medical Center Groningen (NL)
Corresponding author
Kersten, Sander
Venue
Molecular Metabolism
Publisher
Elsevier BV
Published
2014-04
Volume
3
Issue
2
Pages
135-144
ISSN
2212-8778 (ISSN-L)
OpenAlex
W2136342596
Cited by
88
References
58
Citations by year
2026: 4 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 12 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 5
FWCI
4.53
Type
journal article
Language
en
Open access
Locations
  • Molecular Metabolism (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc-nd)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc-nd)
  • Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
Funders
  • Netherlands Nutrigenomics Centre
  • Netherlands Organization for Scientific Research (NWO) (40-00812-98-08030)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
ANGPTL4, pancreatic lipase inhibition, dietary triglycerides, lipoprotein lipase, chylomicrons, enterocytes, fat malabsorption

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