Angptl4 serves as an endogenous inhibitor of intestinal lipid digestion
Open accessAbstract
Dietary triglycerides are hydrolyzed in the small intestine principally by pancreatic lipase. Following uptake by enterocytes and secretion as chylomicrons, dietary lipids are cleared from the bloodstream via lipoprotein lipase. Whereas lipoprotein lipase is inhibited by several proteins including Angiopoietin-like 4 (Angptl4), no endogenous regulator of pancreatic lipase has yet been identified. Here we present evidence that Angptl4 is an endogenous inhibitor of dietary lipid digestion. Angptl4-/- mice were heavier compared to their wild-type counterparts without any difference in food intake, energy expenditure or locomotor activity. However, Angptl4-/- mice showed decreased lipid content in the stools and increased accumulation of dietary triglycerides in the small intestine, which coincided with elevated luminal lipase activity in Angptl4-/- mice. Furthermore, recombinant Angptl4 reduced the activity of pancreatic lipase as well as the lipase activity in human ileostomy output. In conclusion, our data suggest that Angptl4 is an endogenous inhibitor of intestinal lipase activity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ANGPTL4 inhibits pancreatic lipase, decreasing dietary fat absorption.
“It has also been shown to inhibit pancreatic lipase, decreasing dietary fat absorption [179].”
Cites
Bioconductor: open software development for computational biology and bioinformatics
Gentleman, R., Carey, V., Bates, D., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., et al. (2004) · Genome Biology · doi:10.1186/gb-2004-5-10-r80 · Cited by 13,133 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Irizarry, R. A. (2003) · Biostatistics · doi:10.1093/biostatistics/4.2.249 · Cited by 10,603 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · see citing works
Protein Inhibitors of Proteinases
Laskowski, M. C., & Kato, I. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.003113 · Cited by 2,238 · see citing works
Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
Dai, M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gni179 · Cited by 1,797 · see citing works
Pancreatic lipase inhibitors from natural sources: Unexplored potential
Birari, R. B., & Bhutani, K. K. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.07.024 · Cited by 871 · see citing works
Lipoprotein lipase: from gene to obesity
Wang, H., & Eckel, R. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90920.2008 · Cited by 862 · see citing works
Iqbal, J., & Hussain, M. M. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90899.2008 · Cited by 811 · see citing works
Human Pancreatic Digestive Enzymes
Whitcomb, D. C., & Lowe, M. E. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9589-z · Cited by 544 · see citing works
Carrière, F., Barrowman, J. A., Verger, R., & Laugier, R. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90908-u · Cited by 478 · see citing works
Beigneux, A. P., Davies, B. S. J., Gin, P., Weinstein, M. M., Farber, E., Qiao, X., Peale, F. V., Jr., Bunting, S., Walzem, R. L., Wong, J. S., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.002 · Cited by 470 · see citing works
Atypical angiopoietin-like protein that regulates ANGPTL3
Quagliarini, F., Wang, Y., Kozlitina, J., Grishin, N. V., Hyde, R., Boerwinkle, E., Valenzuela, D. M., Murphy, A. J., Cohen, J. C., & Hobbs, H. H. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217552109 · Cited by 451 · see citing works
Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Müller, M., & Kersten, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506519200 · Cited by 433 · see citing works
Köster, A., Chao, Y. B., Mosior, M., Ford, A., Gonzalez-DeWhitt, P. A., Hale, J. E., Li, D., Qiu, Y., Fraser, C. C., Yang, D. D., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0476 · Cited by 427 · see citing works
Sukonina, V., Lõokene, A., Olivecrona, T., & Olivecrona, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604026103 · Cited by 402 · see citing works
Yoshida, K., Shimizugawa, T., Ono, M., & Furukawa, H. (2002) · Journal of Lipid Research · doi:10.1194/jlr.c200010-jlr200 · Cited by 368 · see citing works
GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries
Davies, B. S. J., Beigneux, A. P., Barnes, R. H., Tu, Y., Gin, P., Weinstein, M. M., Nobumori, C., Nyrén, R., Goldberg, I. J., Olivecrona, G., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.016 · Cited by 362 · see citing works
Zhang, R. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.038 · Cited by 345 · see citing works
Interfacial & colloidal aspects of lipid digestion
Wilde, P. J., & Chu, B. S. (2011) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2011.02.004 · Cited by 337 · see citing works
Wang, Y., Quagliarini, F., Gusarova, V., Gromada, J., Valenzuela, D. M., Cohen, J. C., & Hobbs, H. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315292110 · Cited by 317 · see citing works
Alex, S., Lange, K., Amolo, T., Grinstead, J. S., Haakonsson, A. K., Szalowska, E., Koppen, A., Mudde, K., Haenen, D., Al-Lahham, S., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00858-12 · Cited by 300 · see citing works
Wong, H., & Schotz, M. C. (2002) · Journal of Lipid Research · doi:10.1194/jlr.r200007-jlr200 · Cited by 298 · see citing works
Natural Inhibitors of Pancreatic Lipase as New Players in Obesity Treatment
de la Garza, A. L., Milagro, F. I., Boqué, N., Campión, J., & Martínez, J. A. (2011) · Planta Medica · doi:10.1055/s-0030-1270924 · Cited by 285 · see citing works
Lichtenstein, L., Mattijssen, F., de Wit, N. J. W., Georgiadi, A., Hooiveld, G. J. E. J., van der Meer, R., He, Y., Qi, L., Koster, A. M., Tamsma, J. T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.002 · Cited by 269 · see citing works
New insights into the molecular mechanism of intestinal fatty acid absorption
Wang, T. Y., Liu, M., Portincasa, P., & Wang, D. Q. ‐. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12161 · Cited by 266 · see citing works
Lipases and lipolysis in the human digestive tract: where do we stand?
Armand, M. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3280177687 · Cited by 234 · see citing works
Plösch, T., Kok, T., Bloks, V. W., Smit, M. J., Havinga, R., Chimini, G., Groen, A. K., & Kuipers, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206522200 · Cited by 207 · see citing works
Kersten, S., Lichtenstein, L., Steenbergen, E., Mudde, K., Hendriks, H., Hesselink, M. K. C., Schrauwen, P., & Müller, M. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.182147 · Cited by 206 · see citing works
Lichtenstein, L., Berbée, J. F. P., van Dijk, S. J., van Dijk, K. W., Bensadoun, A., Kema, I. P., Voshol, P. J., Müller, M. M., Rensen, P. C. N., & Kersten, S. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.151894 · Cited by 196 · see citing works
Staiger, H., Haas, C., Machann, J., Werner, R., Weisser, M., Schick, F., Machicao, F., Stefan, N., Fritsche, A., & Häring, H.-U. (2009) · Diabetes · doi:10.2337/db07-1438 · Cited by 183 · see citing works
Regulation of triglyceride metabolism by Angiopoietin-like proteins
Mattijssen, F., & Kersten, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.10.010 · Cited by 180 · see citing works
Koliwad, S. K., Kuo, T., Shipp, L. E., Gray, N. E., Backhed, F., So, A. Y.-L., Farese, R. V., & Wang, J.-C. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.025452 · Cited by 164 · see citing works
Govers, M. J., & der Meet, R. V. (1993) · Gut · doi:10.1136/gut.34.3.365 · Cited by 145 · see citing works
Genome-wide analysis of PPARα activation in murine small intestine
Bünger, M., den Bosch, H. D. V.-V., van der Meijde, J., Kersten, S., Hooiveld, G. J. E. J., & Müller, M. M. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00198.2006 · Cited by 143 · see citing works
Georgiadi, A., Lichtenstein, L., Degenhardt, T., Boekschoten, M. V., van Bilsen, M., Desvergne, B., Müller, M. M., & Kersten, S. (2010) · Circulation Research · doi:10.1161/circresaha.110.217380 · Cited by 141 · see citing works
Angiopoietin-like Protein 3 Mediates Hypertriglyceridemia Induced by the Liver X Receptor
Inaba, T., Matsuda, M., Shimamura, M., Takei, N., Terasaka, N., Ando, Y., Yasumo, H., Koishi, R., Makishima, M., & Shimomura, I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213202200 · Cited by 138 · see citing works
Regulation of the angiopoietin-like protein 3 gene by LXR
Kaplan, R. A., Zhang, T., Hernandez, M., Gan, F. X., Wright, S. D., Waters, M. G., & Cai, T. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200367-jlr200 · Cited by 127 · see citing works
Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight
Kim, H.-K., Youn, B., Shin, M.-S., NamKoong, C., Park, K. H., Baik, J., Kim, J. B., Park, J., Lee, K., Kim, Y., et al. (2010) · Diabetes · doi:10.2337/db10-0145 · Cited by 127 · see citing works
Demignot, S., Beilstein, F., & Morel, É. (2013) · Biochimie · doi:10.1016/j.biochi.2013.07.009 · Cited by 117 · see citing works
Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart
Yu, X., Burgess, S. C., Ge, H., Wong, K. K., Naseem, R. H., Garry, D. J., Sherry, A. D., Malloy, C. R., Berger, J. P., & Cai, L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409564102 · Cited by 114 · see citing works
[72] Human pancreatic secretory trypsin inhibitor
Greene, L. J., Pubols, M. H., & Bartelt, D. C. (1976) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(76)45075-9 · Cited by 108 · see citing works
Korecka, A., de Wouters, T., Cultrone, A., Lapaque, N., Pettersson, S., Dore, J. M., Blottière, H. M., & Arulampalam, V. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00293.2012 · Cited by 96 · see citing works
Vahouny, G. V., Satchithanandam, S., Chen, I., Tepper, S. A., Kritchevsky, D., Lightfoot, F. G., & Cassidy, M. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/47.2.201 · Cited by 93 · see citing works
Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase
Lafferty, M. J., Bradford, K. C., Erie, D. A., & Neher, S. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497602 · Cited by 88 · see citing works
Kroupa, O., Vorrsjö, E., Stienstra, R., Mattijssen, F., Nilsson, S. K., Sukonina, V., Kersten, S., Olivecrona, G., & Olivecrona, T. (2012) · BMC Physiology · doi:10.1186/1472-6793-12-13 · Cited by 82 · see citing works
Intestinal lipid absorption is not affected in CD36 deficient mice
Goudriaan, J. R., Dahlmans, V. E. H., Febbraio, M., Teusink, B., Romijn, J. A., Havekes, L. M., & Voshol, P. J. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1020575412789 · Cited by 72 · see citing works
Human Pancreatic Secretory Trypsin Inhibitor
Marchbank, T., Freeman, T. C., & Playford, R. J. (1998) · Digestion · doi:10.1159/000007485 · Cited by 65 · see citing works
Camp, J. G., Jazwa, A. L., Trent, C. M., & Rawls, J. F. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002585 · Cited by 58 · see citing works
Physiological parameters governing the action of pancreatic lipase
Brownlee, I. A., Forster, D. J., Wilcox, M. D., Dettmar, P. W., Seal, C. J., & Pearson, J. P. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000028 · Cited by 48 · see citing works
ANGPTL4 is produced by entero-endocrine cells in the human intestinal tract
Alex, S., Lichtenstein, L., Dijk, W., Mensink, R. P., Tan, N. S., & Kersten, S. (2013) · Histochemistry and Cell Biology · doi:10.1007/s00418-013-1157-y · Cited by 46 · see citing works
Wang, J., Ohmuraya, M., Hirota, M., Baba, H., Zhao, G., Takeya, M., Araki, K., & Yamamura, K. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0425-8 · Cited by 33 · see citing works
Effects of dietary history on energy metabolism and physiological parameters in C57BL/6J mice
Hoevenaars, F. P. M., Keijer, J., Swarts, H. J. M., Snaas‐Alders, S., Bekkenkamp‐Grovenstein, M., & van Schothorst, E. M. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.069518 · Cited by 33 · see citing works
Santas, J., Espadaler, J., Cuñé, J., & Rafecas, M. (2012) · Lipids · doi:10.1007/s11745-012-3682-1 · Cited by 15 · see citing works
Production and secretion of pancreatic secretory trypsin inhibitor in normal human small intestine
Bohe, H., Bohe, M., Lundberg, E., Polling, Å., & OHLSSON, K. (1997) · Journal of Gastroenterology · doi:10.1007/bf02934111 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 58 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Inactivating Variants in <i>ANGPTL4</i> and Risk of Coronary Artery Disease
Dewey, F. E., Gusarova, V., O’Dushlaine, C., Gottesman, O., Trejos, J., Hunt, C., Van Hout, C. V., Habegger, L., Buckler, D., Lai, K.-M. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1510926 · Cited by 497 · see citing works
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
Funcke, J., & Scherer, P. E. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r094060 · Cited by 337 · see citing works
Probiotics and Prebiotics: Present Status and Future Perspectives on Metabolic Disorders
Yoo, J. Y., & Kim, S. S. (2016) · Nutrients · doi:10.3390/nu8030173 · Cited by 330 · see citing works
Chakaroun, R., Massier, L., & Kovacs, P. L. (2020) · Nutrients · doi:10.3390/nu12041082 · Cited by 297 · see citing works
Gonzalez-Gil, A. M., & Elizondo-Montemayor, L. (2020) · Nutrients · doi:10.3390/nu12061899 · Cited by 278 · see citing works
Western diets, gut dysbiosis, and metabolic diseases: Are they linked?
Martinez, K., Leone, V., & Chang, E. B. (2017) · Gut Microbes · doi:10.1080/19490976.2016.1270811 · Cited by 274 · see citing works
Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
Li, H., Zhang, L., Li, J., Wu, Q., Qian, L., He, J., Ni, Y., Kovatcheva‐Datchary, P., Yuan, R. R., Liu, S., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-00988-y · Cited by 270 · see citing works
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
Cândido, F. G., Valente, F. X., Grześkowiak, Ł., Moreira, A. P. B., Rocha, D. M. U. P., & Alfenas, R. D. C. G. (2017) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2017.1343286 · Cited by 241 · see citing works
Lipoprotein lipase and its regulators: an unfolding story
Wu, S. A., Kersten, S., & Qi, L. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.11.005 · Cited by 225 · see citing works
Regulation of lipoprotein lipase by Angptl4
Dijk, W., & Kersten, S. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2013.12.005 · Cited by 199 · see citing works
The role of the gut microbiota in metabolic health
Janssen, A. W. F., & Kersten, S. (2015) · The FASEB Journal · doi:10.1096/fj.14-269514 · Cited by 199 · see citing works
Regulation of lipid metabolism by angiopoietin-like proteins
Dijk, W., & Kersten, S. (2016) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000290 · Cited by 194 · see citing works
Causality of small and large intestinal microbiota in weight regulation and insulin resistance
Scheithauer, T. P. M., Dallinga-Thie, G. M., de Vos, W. M., Nieuwdorp, M., & van Raalte, D. H. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.06.002 · Cited by 188 · see citing works
“Therefore, Angptl4 is able not only to inhibit systemic LPL activity (lipid storage), but also to inhibit luminal LPL (lipid digestion and uptake) [84,86].”
BackgroundPaglia, L. L., Listì, A., Caruso, S., Amodeo, V., Passiglia, F., Bazan, V., & Fanale, D. (2017) · PPAR Research · doi:10.1155/2017/8187235 · Cited by 174 · see citing works
Zheng, Z., Lyu, W., Ren, Y., Li, X., Zhao, S., Yang, H., & Xiao, Y. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.690138 · Cited by 171 · see citing works
Berger, E., Colosetti, P., Jalabert, A., Meugnier, E., Wiklander, O. P. B., Jouhet, J., Errazuriz-Cerda, E., Chanon, S., Gupta, D., Rautureau, G. J. P., et al. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.08.009 · Cited by 161 · see citing works
Regulation of lipoprotein metabolism by ANGPTL3, ANGPTL4, and ANGPTL8
Sylvers-Davie, K. L., & Davies, B. S. J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00195.2021 · Cited by 149 · see citing works
Shelton, C. D., Sing, E., Mo, J., Shealy, N. G., Yoo, W., Thomas, J., Fitz, G. N., Castro, P. R., Hickman, T. T., Torres, T. P., et al. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.09.002 · Cited by 121 · see citing works
Janssen, A. W. F., Katiraei, S., Bartosinska, B., Eberhard, D., Willems van Dijk, K., & Kersten, S. (2018) · Diabetologia · doi:10.1007/s00125-018-4583-5 · Cited by 96 · see citing works
Self-citationGut Dysbiosis and Immune System in Atherosclerotic Cardiovascular Disease (ACVD)
Yoo, J. Y., Sniffen, S. E., Percy, K. C. M., Chidipi, B., & Pallaval, V. B. (2022) · Microorganisms · doi:10.3390/microorganisms10010108 · Cited by 86 · see citing works
Potential mediators linking gut bacteria to metabolic health: a critical view
Janssen, A. W. F., & Kersten, S. (2016) · The Journal of Physiology · doi:10.1113/jp272476 · Cited by 82 · see citing works
Association between intestinal microbiota and inflammatory bowel disease
Zhang, Y., Si, X., Yang, L., Wang, H., Sun, Y. Q., & Liu, N. (2022) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12255 · Cited by 79 · see citing works
Digestion of human milk fat in healthy infants
He, X., McClorry, S., Hernell, O., Lönnerdal, B. L., & Slupsky, C. M. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.08.002 · Cited by 78 · see citing works
Gut microbiota and associated metabolites: key players in high-fat diet-induced chronic diseases
Du, W., Zou, Z., Ye, B., & Zhou, Y. Q. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2494703 · Cited by 78 · see citing works
Triglyceride metabolism and angiopoietin-like proteins in lipoprotein lipase regulation
Li, J., Li, L., Guo, D., Li, S., Zeng, Y., Liu, C., Fu, R., Huang, M., & Xie, W. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.12.029 · Cited by 66 · see citing works
The Gut Microbiome, Energy Homeostasis, and Implications for Hypertension
Riedl, R. A., Atkinson, S. N., Burnett, C. M. L., Grobe, J. L., & Kirby, J. R. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0721-6 · Cited by 58 · see citing works
Zwartjes, M. S. Z., Gerdes, V. E. A., & Nieuwdorp, M. (2021) · Metabolites · doi:10.3390/metabo11080531 · Cited by 50 · see citing works
Jahn, D., Dorbath, D., Schilling, A.-K., Gildein, L., Meier, C. F., Vuille-dit-Bille, R. N., Schmitt, J., Kraus, D., Fleet, J. C., Hermanns, H. M., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.03.007 · Cited by 44 · see citing works
Gut microbiota and obesity: Involvement of the adipose tissue
Guida, S., & Venema, K. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.02.014 · Cited by 43 · see citing works
Role of the Gut in Diabetic Dyslipidemia
Stahel, P., Xiao, C., Nahmias, A., & Lewis, G. F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00116 · Cited by 39 · see citing works
Metabolomics to Explore Impact of Dairy Intake
Zheng, H. X., Clausen, M. R., Dalsgaard, T. K., & Bertram, H. C. (2015) · Nutrients · doi:10.3390/nu7064875 · Cited by 36 · see citing works
Liu, S., Chiu, C., Shi, C.-M., & Chiang, M. (2018) · Marine Drugs · doi:10.3390/md16080251 · Cited by 35 · see citing works
Angiopoietin-like protein 4: a therapeutic target for triglycerides and coronary disease?
Olshan, D. S., & Rader, D. J. (2018) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2018.01.012 · Cited by 30 · see citing works
Rong, B., Wu, Q., Reiter, R. J., & Sun, C. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.06.024 · Cited by 30 · see citing works
Can targeting ANGPTL proteins improve glucose tolerance?
Davies, B. S. J. (2018) · Diabetologia · doi:10.1007/s00125-018-4604-4 · Cited by 30 · see citing works
Deng, M., Kutrolli, E., Sadewasser, A., Michel, S., Joibari, M. M., Jaschinski, F., Olivecrona, G., Nilsson, S. K., & Kersten, S. (2022) · Journal of Lipid Research · doi:10.1016/j.jlr.2022.100237 · Cited by 29 · see citing works
Chen, H., Zhao, H., Qi, X., Sun, Y., Ma, Y., & Li, Q. (2023) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12538 · Cited by 28 · see citing works
Yang, H. J., Xiao, L., & Xu, D. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-07001-0 · Cited by 26 · see citing works
Direct Derivatization vs Aqueous Extraction Methods of Fecal Free Fatty Acids for GC–MS Analysis
Amer, B., Nebel, C., Bertram, H. C., Mortensen, G., & Dalsgaard, T. K. (2015) · Lipids · doi:10.1007/s11745-015-4029-5 · Cited by 26 · see citing works
Blædel, T., Holm, J. B., Sundekilde, U. K., Schmedes, M. S., Hess, A. L., Lorenzen, J. K., Kristiansen, K., Dalsgaard, T. K., Astrup, A., & Larsen, L. H. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.38 · Cited by 22 · see citing works
Janssen, A. W. F., Dijk, W., Boekhorst, J., Kuipers, F., Groen, A. K., Lukovac, S., Hooiveld, G. J. E. J., & Kersten, S. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.07.005 · Cited by 23 · see citing works
Bai, Y.-F., Yue, Z.-L., Wang, Y., Li, Y., Li, C., Liu, X., Shi, R.-H., Huo, N.-N., Li, D.-D., Gao, S., et al. (2022) · Food & Function · doi:10.1039/d2fo03031d · Cited by 20 · see citing works
Kaviani, S., Taylor, C. M., Stevenson, J. L., Cooper, J. A., & Paton, C. M. (2019) · BMC Nutrition · doi:10.1186/s40795-018-0262-7 · Cited by 20 · see citing works
Nakamoto, M., Ishihara, K., Watanabe, T., Hirosue, A., Hino, S., Shinohara, M., Nakayama, H., & Nakao, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169225 · Cited by 16 · see citing works
Postprandial consequences of lipid absorption in the onset of obesity: Role of intestinal CD36
Lebrun, L. J., Milheiro, S. M., Tavernier, A., & Niot, I. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159154 · Cited by 15 · see citing works
Hepatokines, bile acids and ketone bodies are novel Hormones regulating energy homeostasis
Garruti, G., Baj, J., Cignarelli, A., Perrini, S., & Giorgino, F. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1154561 · Cited by 15 · see citing works
Raspberry Polyphenolic Extract Regulates Obesogenic Signals in Hepatocytes
Fotschki, B., Laparra, J. M., & Sójka, M. (2018) · Molecules · doi:10.3390/molecules23092103 · Cited by 13 · see citing works
Ma, C., Chen, X., Zheng, M., Zhang, S., Liu, Q., Lyu, J., Pang, X., & Wang, Y. (2024) · Foods · doi:10.3390/foods13244058 · Cited by 12 · see citing works
Lickwar, C. R., Davison, J. M., Kelly, C., Mercado, G. P., Wen, J., Davis, B. R., Tillman, M., Semova, I., Andres, S. F., Vale, G., et al. (2021) · bioRxiv · doi:10.1016/j.jcmgh.2022.04.013 · Cited by 11 · see citing works
Contribution of organokines in the development of NAFLD/NASH associated hepatocellular carcinoma
Vachher, M., Bansal, S., Kumar, B., Yadav, S., Arora, T. K., Wali, N. M., & Burman, A. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30252 · Cited by 11 · see citing works
Medium chain fatty acids from milk induce angiopoietin-like 4 (ANGPTL4) gene expression
Nielsen, S. D.-H., Amer, B., Young, J. F., Mortensen, G., Petersen, R. K., Kristiansen, K., & Dalsgaard, T. K. (2014) · International Dairy Journal · doi:10.1016/j.idairyj.2014.10.011 · Cited by 10 · see citing works
Nielsen, S. D.-H., Amer, B., Blaabjerg, K., Dalsgaard, T. K., Jessen, R., Petrat-Melin, B., Rasmussen, M. K., Poulsen, H. D., & Young, J. F. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04135 · Cited by 8 · see citing works
Yang, S., Su, X., Lai, M., Liu, X., & Cheng, Y. (2025) · Frontiers in Bioscience-Landmark · doi:10.31083/fbl25862 · Cited by 7 · see citing works
Zhao, X., Liu, H., Pan, Y., Liu, Y., Zhang, F., Ao, H., Zhang, J., Xing, K., & Wang, C. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2021.753725 · Cited by 7 · see citing works
Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4−/−Gpihbp1−/− mice
Cushing, E. M., Sylvers-Davie, K. L., Chi, X., Shetty, S. K., & Davies, B. S. J. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m084749 · Cited by 7 · see citing works
Pereyra, A. S., Wang, Z.-M., Messi, M. L., Zhang, T., Wu, H., Register, T. C., Forbes, E., Devarie‐Baez, N. O., Files, D. C., Abba, M. C., et al. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw192 · Cited by 7 · see citing works
Tong, Z., Peng, J., Lan, H., Sai, W.-W., Li, Y., Xie, J., Tan, Y., Zhang, W., Zhong, M., & Wang, Z. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-02739-z · Cited by 6 · see citing works
Adipose Factor ANGPTL4: Its Role in Aging Mechanisms and Associated Diseases
Wang, X., Chang, H.-C., Gu, X., Zhang, Y., & Bao, Z. (2025) · Clinical Interventions in Aging · doi:10.2147/cia.s522049 · Cited by 5 · see citing works
Emerging role of E4BP4/NFIL3 in metabolic homeostasis
Ran, S., Wang, S., Jin, Q., Liu, G., Xue, X., Qu, P., Peng, L., & Meng, H. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156390 · Cited by 5 · see citing works
Xia, Q., Dong, H., Guo, Y., Fang, K., Hu, M., Xu, L., Lu, F., & Gong, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1007856 · Cited by 5 · see citing works
Gao, N., Zhang, J., Shandilya, U. K., Lumsden, J. S., Bazrgar, A. B., Huyben, D. C., & Karrow, N. A. (2024) · Fishes · doi:10.3390/fishes9120495 · Cited by 5 · see citing works
Liu, S., Feng, S.-A., Chiu, C., & Chiang, M. (2021) · Molecules · doi:10.3390/molecules26165033 · Cited by 5 · see citing works
Shi, K., Zhou, X. M., Dai, J., Gao, Y., Gao, L., Shen, Y., & Chen, S. (2025) · Animals · doi:10.3390/ani15091341 · Cited by 4 · see citing works
Zheng, Z., Lyu, W., Hong, Q., Yang, H., Li, Y., Zhao, S., Ren, Y., & Xiao, Y. (2023) · Animal Bioscience · doi:10.5713/ab.23.0057 · Cited by 3 · see citing works
Villo, L., Risti, R., Reimund, M., Kukk, K., Samel, N., & Lõokene, A. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.158553 · Cited by 3 · see citing works
Secretion of angiopoietin-like 4 protein from intestinal cells
Nielsen, S. D.-H., Jessen, R., Dalsgaard, T. K., & Young, J. F. (2015) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v5i2.171 · Cited by 2 · see citing works
Zhu, J., Lyu, W., Wang, W., Ma, L., Lu, L. Z., Yang, H., & Xiao, Y. (2022) · British Poultry Science · doi:10.1080/00071668.2022.2102888 · Cited by 2 · see citing works
Endogenous and exogenous factors affecting lipoprotein lipase activity
Larsson, M. (2014) · KTH Publication Database DiVA (KTH Royal Institute of Technology) · Cited by 2 · see citing works
Angiopoietin-like 4: An endogenous break of intestinal lipid digestion
Kotzbeck, P., & Zechner, R. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.01.009 · Cited by 1 · see citing works
Pettersson, S., Alexson, S. E. H., Cannon, B., & Rhen, M. (2014)
The role of angiopoietin-like 4 in inflammation
Phua, T. (2017) · doi:10.32657/10356/72319
Effect of Natural Food Components to Reduce the Risk of Obesity: A Review
Limbachiya, P., Kabariya, J. H., Hazra, T., & Ramani, V. M. (2019) · International Journal of Current Microbiology and Applied Sciences · doi:10.20546/ijcmas.2019.809.291
Knockdown of ANGPTL4 May Reduce the Expression of LPL during Differentiation of 3T3-L1 Preadipocyte
Zhao, X., Zhang, F., Liu, Y., Liu, H., Wang, C., Ao, H., & Xing, K. (2021) · Austin Journal of Veterinary Science & Animal Husbandry · doi:10.26420/austinjvetscianimhusb.2021.1076
Evolution of the Angiopoietin-Like Gene Family and Their Role in Lipid Metabolism in PigsPreprint
Zheng, Z., Lyu, W., Hong, Q., Yang, H., Li, Y., Zhao, S., Ren, Y., & Xiao, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-538958/v1
RELATIONSHIP OF LEAKY GUT SYNDROME AND METABOLIC SYNDROME
Tolloto, G. H. V., & Saragiotto, L. (2022) · Health and Society · doi:10.51249/hs.v2i01.661
Lin, H. C., & Lin, D. M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.727174792.793561058
Evolution of The Angiopoietin-Like Gene Family and Their Role in Lipid Metabolism in PigsPreprint
Zheng, Z., Lyu, W., Hong, Q., Yang, H., Li, Y., Zhao, S., Ren, Y., & Xiao, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-538958/v2
Anti-Obesity Activities of Probiotics and Dairy Based Ingredients
Makwana, S., Prajapati, J. B., & Hati, S. (2022) · Springer eBooks · doi:10.1007/978-981-16-8444-9_2
Scheithauer, T. P. M. (2023) · doi:10.5463/thesis.82
Zhu, R. Y., Wang, X., Ma, J., Shi, X., Zhang, Y., Jin, J., & Zhou, H. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1598164
Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up
Ahrens, A. P., Dias, R., Hyötyläinen, T., White, P. A., Orešič, M., Triplett, E. W., & Ludvigsson, J. (2026) · mSystems · doi:10.1128/msystems.01424-25
Muniraj, A., Elango, S. V., Iyer, M., Rani, M. R., Vinayagam, S., Gnanasekaran, L., Yadav, M. K., Rao, K. R. S. S., Vellingiri, B., Mukherjee, A. G., et al. (2026) · Comprehensive physiology · doi:10.1002/cph4.70220 · Cited by 1 · see citing works
Shetty, S. K., Sylvers-Davie, K. L., & Davies, B. S. J. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101124
- Authors
- Mattijssen, F., Alex, S., Swarts, H. J., Groen, A. K., van Schothorst, E. M., & Kersten, S.
- Affiliations
- Wageningen University & Research (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Kersten, Sander
- Venue
- Molecular Metabolism
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 3
- Issue
- 2
- Pages
- 135-144
- ISSN
- 2212-8778 (ISSN-L)
- PMC
- PMC3953698
- OpenAlex
- W2136342596
- Cited by
- 88
- References
- 58
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 12 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 5
- FWCI
- 4.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecular Metabolism (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc-nd)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
- Funders
- Netherlands Nutrigenomics Centre
- Netherlands Organization for Scientific Research (NWO) (40-00812-98-08030)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- ANGPTL4, pancreatic lipase inhibition, dietary triglycerides, lipoprotein lipase, chylomicrons, enterocytes, fat malabsorption
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review