Dyslipidemia management in women of reproductive potential: An Expert Clinical Consensus from the National Lipid Association
Open accessAbstract
Cardiovascular disease (CVD) is the leading cause of death among women and its incidence has been increasing recently, particularly among younger women. Across major professional society guidelines, dyslipidemia management remains a central tenet for atherosclerotic CVD prevention for both women and men. Despite this, women, particularly young women, who are candidates for statin therapy are less likely to be treated and less likely to achieve their recommended therapeutic objectives for low-density lipoprotein cholesterol (LDL-C) levels. Elevated LDL-C and triglycerides are the two most common dyslipidemias that should be addressed during pregnancy due to the increased risk for adverse pregnancy outcomes, such as preeclampsia, gestational diabetes mellitus, and pre-term delivery, as well as pancreatitis in the presence of severe hypertriglyceridemia. In this National Lipid Association Expert Clinical Consensus, we review the roles of nutrition, physical activity, and pharmacotherapy as strategies to address elevated levels of LDL-C and/or triglycerides among women of reproductive age. We include a special focus on points to consider during the shared decision-making discussion regarding pharmacotherapy for dyslipidemia during preconception planning, pregnancy, and lactation.
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Individuals of childbearing potential are less likely to be treated with statins or achieve their LDL cholesterol goals based on their cardiovascular risk.
“Individuals of childbearing potential are less likely to be treated with statins or achieve their LDL cholesterol goals based on their cardiovascular risk (138–140).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [138]
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- Authors
- Agarwala, A., Dixon, D. L., Gianos, E., Kirkpatrick, C. F., Michos, E. D., Satish, P., Birtcher, K. K., Braun, L. T., Pillai, P., Watson, K., Wild, R., & Mehta, L. S.
- Affiliations
- Heart Hospital Baylor Plano (US)
- Virginia Commonwealth University (US)
- Northwell Health (US)
- Idaho State University (US)
- Johns Hopkins University (US)
- The University of Texas at Austin (US)
- University of Houston (US)
- Rush University Medical Center (US)
- University of California, Los Angeles (US)
- University of Oklahoma Health Sciences Center (US)
- The Ohio State University Wexner Medical Center (US)
- Corresponding author
- Agarwala, Anandita
- ORCID
- Venue
- Journal of Clinical Lipidology
- Publisher
- Elsevier BV
- Published
- 2024-09
- Volume
- 18
- Issue
- 5
- Pages
- e664-e684
- ISSN
- 1876-4789 (ISSN-L)
- 1933-2874
- OpenAlex
- W4399215613
- Cited by
- 57
- References
- 138
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 4
- FWCI
- 23.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of clinical lipidology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- dyslipidemia management, women of reproductive age, cardiovascular disease in women, LDL cholesterol, triglycerides, hypertriglyceridemia, pregnancy, preconception planning, lactation, statin therapy, atherosclerotic cardiovascular disease prevention, shared decision-making, nutrition, physical activity, preeclampsia, gestational diabetes mellitus, pancreatitis
- MeSH terms
- Female, Humans, Pregnancy, Dyslipidemias
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