Abnormal serum lipid profile in Brazilian police officers with post-traumatic stress disorder
Open accessAbstract
Background To measure the serum lipid composition of a sample of Brazilian police officers with and without PTSD regularly exposed to potentially traumatic situations. Methods A cross-sectional survey was conducted with 118 active duty male police officers. Serum concentrations for total cholesterol, LDL-C, HDL-C, and triglycerides were enzymatically determined. Body mass index (BMI) was obtained for each participant. Results Officers with PTSD exhibited significantly higher serum total cholesterol, LDL-C and triglycerides levels than those without PTSD. Total cholesterol and triglycerides, but not LDL-C, remained associated with PTSD diagnosis after controlling for confounding influences (i.e. socio-demographics, BMI, and tobacco, alcohol and medication use). Limitations The sample size was small. A nutritional interview was employed instead of established scales to assess alimentary habits, tobacco or alcohol consumption. A self-report screening tool was used to assess the prevalence of PTSD. Conclusions The association between PTSD and abnormal serum lipid profile and a tendency to exhibit higher BMI suggests that individuals with PTSD may be at increased risk for developing metabolic syndrome, a condition that by itself could account for many of the most serious PTSD-related physical health problems.
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Chronic distress is associated with detrimental processes, including hypercoagulability, dyslipidemia, impaired glucose control, and increased inflammatory processes and impaired immune responses.
“Specifically, chronic distress is associated with detrimental processes, including hypercoagulability, dyslipidemia, 112-114 impaired glucose control, 115,116 and increased inflammatory processes and impaired immune responses. 95,117,118”
From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [112]
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- Berger W, Mendlowicz M, Souza W, Figueira I. Equivalência semântica da versão em português da PTSD Checklist- Civilian Version (PCL-C) para rastreamento do transtorno de estresse pós-traumático. Revista de Psiquiatria do Rio Grande do Sul. 2004;26(2) [Google Scholar]
- Blanchard EB, Jones-Alexander J, Buckley TC, Forneris CA. Psychometric properties of the PTSD Checklist (PCL) Behav Res Ther. 1996;34(8):669–673. doi: 10.1016/0005-7967(96)00033-2. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
- Kagan BL, Leskin G, Haas B, Wilkins J, Foy D. Elevated lipid levels in Vietnam veterans with chronic posttraumatic stress disorder. Biol Psychiatry. 1999;45(3):374–377. doi: 10.1016/s0006-3223(98)00059-6. [DOI] [PubMed] [Google Scholar] · DOI
- Karlovic D, Buljan D, Martinac M, Marcinko D. Serum lipid concentrations in Croatian veterans with post-traumatic stress disorder,post-traumatic stress disorder comorbid with major depressive disorder,or major depressive disorder. J Korean Med Sci. 2004a;19(3):431–436. doi: 10.3346/jkms.2004.19.3.431. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
- Karlovic D, Martinac M, Buljan D, Zoricic Z. Relationship between serum lipid concentrations and posttraumatic stress disorder symptoms in soldiers with combat experiences. Acta Med Okayama. 2004b;58(1):23–27. doi: 10.18926/AMO/32118. [DOI] [PubMed] [Google Scholar] · DOI
- Rosmond R. Role of stress in the pathogenesis of the metabolic syndrome. Psychoneuroendocrinology. 2005;30(1):1–10. doi: 10.1016/j.psyneuen.2004.05.007. [DOI] [PubMed] [Google Scholar] · DOI
- Schnurr PP, Green BL. Trauma and Health: Physical Health Consequences of Exposure to Extreme Stress. American Psychological Association; Washington, DC: 2004. [Google Scholar]
- Tochigi M, Umekage T, Otani T, Kato T, Iwanami A, Asukai N, Sasaki T, Kato N. Serum cholesterol, uric acid and cholinesterase in victims of the Tokyo subway sarin poisoning: a relation with post-traumatic stress disorder. Neurosci Res. 2002;44(3):267–272. doi: 10.1016/s0168-0102(02)00146-3. [DOI] [PubMed] [Google Scholar] · DOI
- Tochigi M, Otani T, Yamasue H, Kasai K, Kato T, Iwanami A, Kato N, Sasaki T. Support for relationship between serum cholinesterase and posttraumatic stress disorder; 5-year follow-ups of victims of the Tokyo subway sarin poisoning. Neurosci Res. 2005;52(2):129–131. doi: 10.1016/j.neures.2005.03.012. [DOI] [PubMed] [Google Scholar] · DOI
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- Authors
- Maia, D. B., Marmar, C. R., Mendlowicz, M. V., Metzler, T., Nóbrega, A., Peres, M. C., Coutinho, E. S., Volchan, E., & Figueira, I.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- University of California, San Francisco (US)
- Escola Nacional de Saúde Pública Sergio Arouca (BR)
- Corresponding author
- Maia, Deborah Bezerra
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2008-04
- Volume
- 107
- Issue
- 1-3
- Pages
- 259-263
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC3974924
- OpenAlex
- W2113340035
- Cited by
- 86
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 5 · 2017: 5 · 2016: 6 · 2015: 10 · 2014: 7 · 2013: 9 · 2012: 4
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01-MH56350-01A1, R01MH056350)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Health Professions › Occupational Therapy › Occupational Health and Performance
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- post-traumatic stress disorder, lipid profile, police officers, total cholesterol, LDL cholesterol, triglycerides, HDL cholesterol, body mass index, metabolic syndrome, occupational trauma exposure
- MeSH terms
- Adrenergic beta-Antagonists, Adult, Alcohol Drinking, Brazil, Cross-Sectional Studies, Humans, Hyperlipidemias, Life Change Events, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Smoking, Stress Disorders, Post-Traumatic, Triglycerides, Comorbidity, Body Mass Index, Police
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