Posttraumatic stress disorder is a risk factor for metabolic syndrome in an impoverished urban population
Open accessAbstract
Objective Metabolic syndrome is associated with elevated risk for cardiovascular disease and diabetes and has increased prevalence in low-income African Americans, which constitutes a significant health disparity. The mechanisms responsible for this disparity remain unclear; the current study investigated the relationship between posttraumatic stress disorder (PTSD) and metabolic syndrome.Method We assessed childhood and adult trauma history, major depressive disorder, PTSD and the components of metabolic syndrome in an urban population. We recruited 245 low-socioeconomic-status, primarily African American subjects from general medical clinics in an inner-city hospital.Results Trauma exposure was extremely prevalent, with 90.6% of subjects reporting at least one significant trauma and 18.8% of subjects meeting criteria for current PTSD. Metabolic syndrome was also prevalent in this population (33.2%), with significantly higher rates among patients with current PTSD (47.8%, P<.05). After controlling for demographics, smoking history, antipsychotic use, depression and exercise, current PTSD remained the only significant predictor of metabolic syndrome (P=.006).Conclusions PTSD is associated with increased rates of metabolic syndrome within a traumatized, impoverished urban population. Further studies should investigate if PTSD treatment may reduce the rates of metabolic syndrome, improve overall health outcomes and decrease health care disparities in minority populations.
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A proinflammatory state may serve as an underlying biological mechanism by which PTSD and other fear- and anxiety-based disorders are highly co-morbid with CVD and metabolic syndrome, as well as other physical illnesses.
“A proinflammatory state may serve as an underlying biological mechanism by which PTSD and other fear-and anxietybased disorders are highly co-morbid with CVD (Boscarino and Chang, 1999a) and metabolic syndrome (Weiss et al, 2011), as well as other physical illnesses (Boscarino, 2004).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Weiss et al, 2011
The Discussion (page unavailable) reports an association between current PTSD and metabolic syndrome, supporting the part of the sentence attached to Weiss et al. It proposes stress-response and HPA-axis pathways, but does not identify a proinflammatory state as the underlying mechanism or establish the association for other fear- and anxiety-based disorders. (LLM, conf=0.85)
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- Authors
- Weiss, T., Skelton, K., Phifer, J., Jovanovic, T., Gillespie, C. F., Smith, A., Umpierrez, G., Bradley, B., & Ressler, K. J.
- Affiliations
- Emory University (US)
- Atlanta VA Medical Center (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ressler, Kerry J.
- ORCID
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 33
- Issue
- 2
- Pages
- 135-142
- ISSN
- 0163-8343 (ISSN-L)
- PMC
- PMC3099039
- OpenAlex
- W2171714079
- Cited by
- 87
- References
- 66
- Citations by year
- 2025: 4 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 2 · 2020: 8 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 9 · 2015: 16 · 2014: 11 · 2013: 8 · 2012: 5
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- General Hospital Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000454)
- National Institute of Mental Health (K23MH082256, R01MH071537)
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK083036)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Social Sciences › Psychology › Clinical Psychology › Migration, Health and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- post-traumatic stress disorder, metabolic syndrome, health disparities, African Americans, low socioeconomic status, urban population, childhood trauma, major depressive disorder, trauma exposure, cardiovascular risk, diabetes risk
- MeSH terms
- Adult, Major Depressive Disorder, Female, Georgia, Humans, Male, Middle Aged, Poverty, Risk Factors, Stress Disorders, Post-Traumatic, Urban Population, Metabolic Syndrome, Health Status Disparities
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