Prefrontal cortical and striatal activity to happy and fear faces in bipolar disorder is associated with comorbid substance abuse and eating disorder
Open accessAbstract
Background The spectrum approach was used to examine contributions of comorbid symptom dimensions of substance abuse and eating disorder to abnormal prefrontal-cortical and subcortical-striatal activity to happy and fear faces previously demonstrated in bipolar disorder (BD).Method Fourteen remitted BD-type I and sixteen healthy individuals viewed neutral, mild and intense happy and fear faces in two event-related fMRI experiments. All individuals completed Substance-Use and Eating-Disorder Spectrum measures. Region-of-Interest analyses for bilateral prefrontal and subcortical-striatal regions were performed.Results BD individuals scored significantly higher on these spectrum measures than healthy individuals (p<0.05), and were distinguished by activity in prefrontal and subcortical-striatal regions. BD relative to healthy individuals showed reduced dorsal prefrontal-cortical activity to all faces. Only BD individuals showed greater subcortical-striatal activity to happy and neutral faces. In BD individuals, negative correlations were shown between substance use severity and right PFC activity to intense happy faces (p<0.04), and between substance use severity and right caudate nucleus activity to neutral faces (p<0.03). Positive correlations were shown between eating disorder and right ventral putamen activity to intense happy (p<0.02) and neutral faces (p<0.03). Exploratory analyses revealed few significant relationships between illness variables and medication upon neural activity in BD individuals.Limitations Small sample size of predominantly medicated BD individuals.Conclusion This study is the first to report relationships between comorbid symptom dimensions of substance abuse and eating disorder and prefrontal-cortical and subcortical-striatal activity to facial expressions in BD. Our findings suggest that these comorbid features may contribute to observed patterns of functional abnormalities in neural systems underlying mood regulation in BD.
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Preliminary evidence indicates that comorbid symptoms, particularly anxiety, eating or substance abuse disorder, may alter patterns of neuronal activation during recognition of emotional faces in patients with bipolar disorder.
“Preliminary evidence indicates that comorbid symptoms, and in particular the presence of an anxiety, eating or substance abuse disorder, may alter patterns of neuronal activation during recognition of emotional faces in patients with bipolar disorder”
From Systematic review of the neural basis of social cognition in patients with mood disorders (2012) · cites this paper as [91]
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- Authors
- Hassel, S., Almeida, J. R., Frank, E., Versace, A., Nau, S. A., Klein, C. R., Kupfer, D. J., & Phillips, M. L.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Hassel, Stefanie
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 118
- Issue
- 1-3
- Pages
- 19-27
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC2745518
- OpenAlex
- W2062305936
- Cited by
- 54
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 12
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Aston Publications Explorer (Aston University) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- University of Pittsburgh
- Carnegie Mellon University
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (5r01mh076971-05)
- National Institute of Mental Health (R01-MH076971, 5R01 MH076971-01)
- Brain Injury Research Center
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- bipolar disorder, substance abuse, eating disorders, comorbidities, facial expression processing, happy faces, fearful faces, prefrontal cortex, striatum, caudate nucleus, ventral putamen, mood regulation, event-related fMRI
- MeSH terms
- Adolescent, Adult, Arousal, Bipolar Disorder, Corpus Striatum, Dominance, Cerebral, Facial Expression, Fear, Female, Happiness, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Pattern Recognition, Visual, Psychotropic Drugs, Reference Values, Comorbidity, Prefrontal Cortex, Substance-Related Disorders, Young Adult, Binge-Eating Disorder
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