Does cytokine-induced depression differ from idiopathic major depression in medically healthy individuals?
Open accessAbstract
Background Cytokines of the innate immune response may contribute to behavioral alterations that resemble major depression as manifested in medically healthy individuals.Methods To explore potential similarities and differences between cytokine-induced depression and idiopathic major depression in healthy subjects, dimensional analyses comparing specific symptom dimensions of depression were conducted in 20 patients with malignant melanoma administered the innate immune cytokine, interferon (IFN)-alpha, and 28 medically healthy subjects with major depression of similar age and gender distribution. The Hamilton Rating Scale for Depression was used to assess severity of individual depressive symptoms.Results Severity of symptoms of anxiety, depressed mood, and impaired work/activities were comparable between patients with IFN-alpha-induced depression and medically healthy depressed patients. Interestingly, however, compared to medically healthy patients with major depression, patients with IFN-alpha-induced depression reported significantly greater psychomotor retardation and weight loss and significantly less severe feelings of guilt.Limitations The relatively small sample size limited statistical power to detect small differences in symptom expression among groups.Conclusions The data suggest that there is considerable overlap in symptom expression between cytokine-induced depression and idiopathic depression in medically healthy subjects. Nevertheless, differences in isolated symptom domains suggest that cytokines may preferentially target neurocircuits relevant to psychomotor activity (e.g. basal ganglia), while having a limited effect on cognitive distortions regarding self-appraisal.
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The fatigue of depression, often a residual symptom of SSRI therapy, is a prominent feature of cytokine-induced depression and may represent cytokine effects on basal ganglia and dopamine function.
“The fatigue of depression, which is often a residual symptom of SSRI therapy, is a prominent feature of cytokine-induced depression, and may represent cytokine effects on the basal ganglia and dopamine (DA) function (Capuron et al., 2001, Majer et al., 2008, Capuron et al., 2009).”
From Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications (2013) · cites this paper as Capuron et al., 2009
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- Authors
- Capuron, L., Fornwalt, F. B., Knight, B. T., Harvey, P. D., Ninan, P. T., & Miller, A. H.
- Affiliations
- Université de Bordeaux (FR)
- Emory University (US)
- Wyeth (US)
- Corresponding author
- Miller, Andrew H.
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 119
- Issue
- 1-3
- Pages
- 181-185
- ISSN
- 0165-0327 (ISSN-L)
- PMC
- PMC2763953
- OpenAlex
- W2133918045
- Cited by
- 164
- References
- 27
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 11 · 2020: 4 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 21 · 2015: 6 · 2014: 7 · 2013: 12 · 2012: 27
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000454)
- National Institute of Mental Health (R01MH067990, MH-00680, MH 60723, R01MH060723, K05MH069124)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- interferon-alpha, psychomotor retardation, weight loss, guilt, healthy volunteers, basal ganglia, self-assessment
- MeSH terms
- Adult, Aged, Major Depressive Disorder, Female, Guilt, Humans, Male, Melanoma, Middle Aged, Psychiatric Status Rating Scales, Psychomotor Performance, Weight Loss, Interferon-alpha
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