The role of inflammatory mediators in the biology of major depression: Central nervous system cytokines modulate the biological substrate of depressive symptoms, regulate stress-responsive systems, and contribute to neurotoxicity and neuroprotection

Pathologic Basis of Disease.

(1980) · Annals of Internal Medicine · doi:10.7326/0003-4819-92-3-460_4 · Cited by 4,593 · see citing works

Biologic basis for interleukin-1 in disease.

Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 3,380 · see citing works

Hippocampal atrophy in recurrent major depression

Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932 · see citing works

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

March, C. J., Mosley, B., Larsen, A., Cerretti, D. P., Braedt, G., Price, V. L., Gillis, S. A., Henney, C. S., Kronheim, S. R., Grabstein, K. H., et al. (1985) · Nature · doi:10.1038/315641a0 · Cited by 1,559 · see citing works

Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor

Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., & Vale, W. (1987) · Science · doi:10.1126/science.2821621 · Cited by 1,504 · see citing works

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485 · see citing works

Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1

Berkenbosch, F., van Oers, J., del Rey, A., Tilders, F., & Besedovsky, H. (1987) · Science · doi:10.1126/science.2443979 · Cited by 1,151 · see citing works

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

Hannum, C. H., Wilcox, C. J., Arend, W. P., Joslin, F. G., Dripps, D. J., Heimdal, P. L., Armes, L. G., Sommer, A., Eisenberg, S. P., & Thompson, R. C. (1990) · Nature · doi:10.1038/343336a0 · Cited by 1,122 · see citing works

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

Eisenberg, S. P., Evans, R. J., Arend, W. P., Verderber, E. L., Brewer, M. T., Hannum, C. H., & Thompson, R. C. (1990) · Nature · doi:10.1038/343341a0 · Cited by 1,088 · see citing works

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

Sims, J. E., March, C. J., Cosman, D. J., Widmer, M. B., MacDonald, H. R., McMahan, C. J., Grubin, C. E., Wignall, J. M., Jackson, J. L., Call, S. M., et al. (1988) · Science · doi:10.1126/science.2969618 · Cited by 877 · see citing works

Cloning and expression of murine interleukin-1 cDNA in Escherichia coli

Lomedico, P. T., Gubler, U., Hellmann, C. P., Dukovich, M., Giri, J. G., Pan, Y. E., Collier, K. J., Semionow, R., Chua, A. O., & Mizel, S. B. (1984) · Nature · doi:10.1038/312458a0 · Cited by 816 · see citing works

Cytokines and the nervous system I: expression and recognition

Hopkins, S. J., & Rothwell, N. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80029-2 · Cited by 793 · see citing works

Responses to Corticotropin-Releasing Hormone in the Hypercortisolism of Depression and Cushing's Disease

Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142101 · Cited by 766 · see citing works

Interleukin-1 Immunoreactive Innervation of the Human Hypothalamus

Breder, C. D., Dinarello, C. A., & Saper, C. B. (1988) · Science · doi:10.1126/science.3258444 · Cited by 759 · see citing works

Release of Multiple Hormones by a Direct Action of Interleukin-1 on Pituitary Cells

Bernton, E. W., Beach, J. E., Holaday, J. W., Smallridge, R. C., & Fein, H. G. (1987) · Science · doi:10.1126/science.2821620 · Cited by 671 · see citing works

Depression and the Course of Coronary Artery Disease

Glassman, A. H., & Shapiro, P. A. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.4 · Cited by 671 · see citing works

A novel IL‐1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

McMahan, C. J., Slack, J. L., Mosley, B., Cosman, D. J., Lupton, S., Brunton, L. L., Grubin, C. E., Wignall, J. M., Jenkins, N. A., & Brannan, C. I. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07831.x · Cited by 663 · see citing works

Prevention of Vertebrate Neuronal Death by the crmA Gene

Gagliardini, V., Fernandez, P.-A., Lee, R. K. K., Drexler, H. C. A., Rotello, R. J., Fishman, M. C., & Yuan, J. (1994) · Science · doi:10.1126/science.8303301 · Cited by 612 · see citing works

Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims

Nemeroff, C. B. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800300075009 · Cited by 555 · see citing works

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

Relton, J. K., & Rothwell, N. J. (1992) · Brain Research Bulletin · doi:10.1016/0361-9230(92)90033-t · Cited by 548 · see citing works

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

Layé, S., Parnet, P., Goujon, E., & Dantzer, R. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90197-x · Cited by 500 · see citing works

Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene Expression

Barone, F. C., White, R. F., Spera, P. A., Ellison, J. A., Currie, R. W., Wang, X., & Feuerstein, G. (1998) · Stroke · doi:10.1161/01.str.29.9.1937 · Cited by 485 · see citing works

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

Bauer, J., Strauss, S., Schreiter-Gasser, U., Ganter, U., Schlegel, P., Witt, I., Yolk, B., & Berger, M. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80737-n · Cited by 483 · see citing works

Depression, stress and immunological activation: The role of cytokines in depressive disorders

Connor, T. J., & Leonard, B. E. (1998) · Life Sciences · doi:10.1016/s0024-3205(97)00990-9 · Cited by 478 · see citing works

Amygdala core nuclei volumes are decreased in recurrent major depression

Sheline, Y. I., Gado, M. H., & Price, J. L. (1998) · NeuroReport · doi:10.1097/00001756-199806220-00021 · Cited by 472 · see citing works

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

Ericsson, A., Liu, C., Hart, R. P., & Sawchenko, P. E. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903610410 · Cited by 471 · see citing works

Bone Mineral Density in Women with Depression

Michelson, D., Stratakis, C., Hill, L., Reynolds, J., Galliven, E., Chrousos, G., & Gold, P. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610173351602 · Cited by 471 · see citing works

Psychiatric implications of basic and clinical studies with corticotropin-releasing factor.

Gold, P., Chrousos, G., Kellner, C., Post, R., Roy, A., Augerinos, P., Schulte, H., Oldfield, E., & Loriaux, D. (1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.5.619 · Cited by 460 · see citing works

Exposure to Acute Stress Induces Brain Interleukin-1β Protein in the Rat

Nguyen, K. T., Deak, T., Owens, S. M., Kohno, T., Fleshner, M., Watkins, L. R., & Maier, S. F. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-06-02239.1998 · Cited by 460 · see citing works

Abnormal Hypothalamic–Pituitary–Adrenal Function in Anorexia Nervosa

Gold, P. W., Gwirtsman, H. E., Avgerinos, P. C., Nieman, L. K., Gallucci, W. T., Kaye, W. H., Jimerson, D. C., Ebert, M. H., Rittmaster, R. S., Loriaux, D. L., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142102 · Cited by 455 · see citing works

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

Selmaj, K. W., Raine, C. S., & Cross, A. H. (1991) · Annals of Neurology · doi:10.1002/ana.410300510 · Cited by 441 · see citing works

Indicators of immune activation in major depression

Sluzewska, A., RYBAKOWSKI, J. K., Bosmans, E., Sobieska, M., Berghmans, R., Maes, M. H. J., & Wiktorowicz, K. (1996) · Psychiatry Research · doi:10.1016/s0165-1781(96)02783-7 · Cited by 384 · see citing works

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

Quagliarello, V., Wispelwey, B., Long, W. J., & Scheld, W. M. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115140 · Cited by 372 · see citing works

Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?

(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.8.1189 · Cited by 364 · see citing works

Leptin actions on food intake and body temperature are mediated by IL-1

Luheshi, G. N., Gardner, J. D., Rushforth, D. A., Loudon, A. S., & Rothwell, N. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7047 · Cited by 362 · see citing works

Blunted Corticotropin and Normal Cortisol Response to Human Corticotropin-Releasing Factor in Depression

Holsboer, F., von Bardeleben, U., Gerken, A., Stalla, G. K., & Müller, O. A. (1984) · New England Journal of Medicine · doi:10.1056/nejm198410253111718 · Cited by 348 · see citing works

Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

Brady, L. S., Whitfield, H. J., Fox, R. J., Gold, P. W., & Herkenham, M. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115086 · Cited by 338 · see citing works

In situ histochemical localization of type I interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse

Cunningham, E. T., Wada, E., Carter, D., Tracey, D. E., Battey, J., & Souza, E. B. D. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-01101.1992 · Cited by 334 · see citing works

Inducible nitric oxide synthase gene expression in the brain during systemic inflammation

Wong, M.-L., Rettori, V., AL-Shekhlee, A., Bongiorno, P. B., Canteros, G., McCann, S. M., Gold, P. W., & Licinio, J. (1996) · Nature Medicine · doi:10.1038/nm0596-581 · Cited by 286 · see citing works

Immobilization stress induces interleukin-1β mRNA in the rat hypothalamus

Minami, M., Kuraishi, Y., Yamaguchi, T., Nakai, S., Hirai, Y., & Satoh, M. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90944-o · Cited by 258 · see citing works

Reciprocal changes in corticotropin-releasing factor (CRF)-like immunoreactivity and CRF receptors in cerebral cortex of Alzheimer's disease

Souza, E. B. D., Whitehouse, P. J., Kuhar, M. J., Price, D. L., & Vale, W. (1986) · Nature · doi:10.1038/319593a0 · Cited by 255 · see citing works

Effect of bacterial endotoxin and interleukin-1 beta on hippocampal serotonergic neurotransmission, behavioral activity, and free corticosterone levels: an in vivo microdialysis study

Linthorst, A., Flachskamm, C., Müller-Preuss, P., Holsboer, F., & Reul, J. M. H. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02920.1995 · Cited by 233 · see citing works

Cytokines and their receptors in the central nervous system: Physiology, pharmacology, and pathology

Rothwell, N. J., Luheshi, G., & Toulmond, S. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02033-0 · Cited by 233 · see citing works

Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide

Quan, N., Sundar, S. K., & Weiss, J. M. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90188-0 · Cited by 230 · see citing works

IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP

Parnet, P., Garka, K. E., Bonnert, T. P., Dower, S., & Sims, J. E. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.3967 · Cited by 223 · see citing works

Interleukin (IL) 1β, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: Pathophysiological implications

Wong, M., Bongiorno, P. B., Rettori, V., McCann, S. M., & Licinio, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.227 · Cited by 222 · see citing works

Pathways and mechanisms for cytokine signaling of the central nervous system.

Licinio, J., & Wong, M. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119846 · Cited by 220 · see citing works

An assessment of the effects of central interleukin-1β, -2, -6, and tumor necrosis factor-α administration on some behavioural, neurochemical, endocrine and immune parameters in the rat

Connor, T., Song, C., Leonard, B. E., Merali, Z., & Anisman, H. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00533-2 · Cited by 195 · see citing works

Localization of type I interleukin-1 receptor mRNA in the rat brain

Yabuuchi, K., Minami, M., Katsumata, S., & Satoh, M. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90180-5 · Cited by 186 · see citing works

Cytokines and depression: fortuitous or causative association?

Dantzer, R., Wollman, E., Vitkovic, L., & Yirmiya, R. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000572 · Cited by 174 · see citing works

Purification and characterization of a novel soluble receptor for interleukin 1.

Symons, J. A., Eastgate, J., & Duff, G. W. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.5.1251 · Cited by 171 · see citing works

Endotoxin-induced corticotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1

Kakucska, I., Qi, Y., Clark, B. D., & Lechan, R. M. (1993) · Endocrinology · doi:10.1210/endo.133.2.8344218 · Cited by 161 · see citing works

Vagotomy attenuates behavioural effects of interleukin-1 injected peripherally but not centrally

Bluthe, R.-M., Michaud, B., Kelley, K. W., & Dantzer, R. (1996) · NeuroReport · doi:10.1097/00001756-199606170-00008 · Cited by 158 · see citing works

Regulation of the Human Serotonin Transporter by Interleukin-1β

Ramamoorthy, S., Ramamoorthy, J. D., Prasad, P. D., Bhat, G. K., Mahesh, V. B., Leibach, F. H., & Ganapathy, V. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2659 · Cited by 156 · see citing works

The nitric oxide hypothesis of aging

McCann, S. M., Licinio, J., Wong, M., Yu, W. H., Karanth, S., & Rettori, V. (1998) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00050-3 · Cited by 151 · see citing works

Expression of interleukin 1α, interleukin 1β and interleukin 1 receptor antagonist mRNA in mouse brain: regulation by bacterial lipopolysaccharide (LPS) treatment

Gabellec, M., Griffais, R., Fillion, G., & Haour, F. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(95)00042-q · Cited by 145 · see citing works

Endogenous Interleukin-1 Receptor Antagonist is Neuroprotective

Loddick, S. A., Wong, M., Bongiorno, P. B., Gold, P. W., Licinio, J., & Rothwell, N. J. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6436 · Cited by 140 · see citing works

Hippocampal atrophy in major depression: a result of depression-induced neurotoxicity?

Sheline, Y. I. (1996) · PubMed · Cited by 137 · see citing works

Microinjection of a cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever

Scammell, T. E., Griffin, J. D., Elmquist, J. K., & Saper, C. B. (1998) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1998.274.3.r783 · Cited by 130 · see citing works

Brain iNOS: current understanding and clinical implications

Licinio, J., Prolo, P., McCann, S. M., & Wong, M. (1999) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01453-7 · Cited by 120 · see citing works

Localization of Interleukin 1 Type I Receptor mRNA in Rat Brain

Wong, M., & Licinio, J. (2006) · NeuroImmunoModulation · doi:10.1159/000097143 · Cited by 118 · see citing works

Localization of Interleukin-1 Receptor Antagonist mRNA in Rat Brain

Licinio, J., Wong, M., & Gold, P. W. (1991) · Endocrinology · doi:10.1210/endo-129-1-562 · Cited by 106 · see citing works

Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever

Scammell, T. E., Elmquist, J. K., & Saper, C. B. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.2.r333 · Cited by 102 · see citing works

Corticotrophin-releasing factor antagonist inhibits neuronal damage induced by focal cerebral ischaemia or activation of NMDA receptors in the rat brain

Strijbos, P. J. L. M., Relton, J. K., & Rothwell, N. J. (1994) · Brain Research · doi:10.1016/0006-8993(94)91485-0 · Cited by 87 · see citing works

Interleukin-13 induces expression and release of interleukin-1 decoy receptor in human polymorphonuclear cells.

Colotta, F., Re, F., Muzio, M., Polentarutti, N., Minty, A. J., Caput, D., Ferrara, P., & Mantovani, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99886-8 · Cited by 86 · see citing works

Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats

Bluthé, R.-M., Beaudu, C., Kelley, K. W., & Dantzer, R. (1995) · Brain Research · doi:10.1016/0006-8993(95)00194-u · Cited by 82 · see citing works

Interleukin-1 mediates behavioural but not metabolic effects of tumor necrosis factor α in mice

Bluthé, R.-M., Dantzer, R., & Kelley, K. W. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90184-r · Cited by 79 · see citing works

Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)

Lovenberg, T. W., Crowe, P. D., Liu, C., Chalmers, D. T., Liu, X.-J., Liaw, C. W., Clevenger, W., Oltersdorf, T., Souza, E. B. D., & Maki, R. A. (1996) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(96)00047-1 · Cited by 79 · see citing works

Increased Expression of Tumor Necrosis Factor-α Receptors in the Brains of Patients With AIDS

Sippy, B. D., Hofman, F. M., Wallach, D., & Hinton, D. R. (1995) · Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology · doi:10.1097/00042560-199510050-00004 · Cited by 79 · see citing works

Behavioral and neural influences on cellular immune responses: effects of stress and interleukin-1.

Weiss, J. M., Sundar, S. K., Becker, K. J., & Cierpial, M. A. (1989) · PubMed · Cited by 78 · see citing works

Stress system abnormalities in melancholic and atypical depression: molecular, pathophysiological, and therapeutic implications.

Gold, P., Wong, M., Chrousos, G. P., & Licinio, J. (1996) · PubMed · Cited by 77 · see citing works

Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury

Lyons, M., Anderson, R. E., & Meyer, F. B. (1991) · Brain Research · doi:10.1016/0006-8993(91)91310-w · Cited by 71 · see citing works

IL-1β, IL-1 receptor type I and iNOS gene expression in rat brain vasculature and perivascular areas

Wong, M., Bongiorno, P. B., Alshekhlee, A., Esposito, A. A., Khatri, P., & Licinio, J. (1996) · Neuroreport · doi:10.1097/00001756-199611040-00008 · Cited by 70 · see citing works

Interleukin-6 (IL-6) is secreted from the brain after intracerebroventricular injection of IL-1 beta in rats

Romero, L. I., Kakucska, I., Lechan, R. M., & Reichlin, S. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.270.3.r518 · Cited by 59 · see citing works

Roles of IL-1 and TNF-alpha in endotoxin-induced activation of nitric oxide synthase in cultured rat brain cells

Romero, L. I., Tatro, J. B., Field, J. A., & Reichlin, S. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.270.2.r326 · Cited by 59 · see citing works

Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies

Liu, C., Chalmers, D. T., Maki, R. A., & Souza, E. B. D. (1996) · Journal of Neuroimmunology · doi:10.1016/0165-5728(96)00016-1 · Cited by 59 · see citing works

Mechanisms of the Behavioral Effects of Interleukin 1 Role of Prostaglandins and CRFa

Bluthé, R.-M., Crestani, F., KELLEY, K. W., & Dantzer, R. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb49135.x · Cited by 58 · see citing works

Induction of interleukin-1β and interleukin-1 receptor antagonist mRNA by chronic treatment with various psychotropics in widespread area of rat brain

Suzuki, E., Shintani, F., Kanba, S., Asai, M., & Nakaki, T. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12985-2 · Cited by 55 · see citing works

Focal cerebral ischemia induces CRH mRNA in rat cerebral cortex and amygdala

Wong, M., Loddick, S. A., Bongiorno, P. B., Gold, P. W., Rothwell, N. J., & Licinio, J. (1995) · Neuroreport · doi:10.1097/00001756-199509000-00019 · Cited by 52 · see citing works

Localization of Interleukin-1βP Converting Enzyme mRNA in Rat Brain Vasculature: Evidence that the Genes Encoding the Interleukin-1 System Are Constitutively Expressed in Brain Blood Vessels

Wong, M., Bongiorno, P. B., Gold, P. W., & Licinio, J. (1995) · NeuroImmunoModulation · doi:10.1159/000096884 · Cited by 47 · see citing works

Cytokine interactions and cytokine balance in the brain: relevance to neurology and psychiatry

Plata‐Saláman, C. R., & Turrin, N. P. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000528 · Cited by 42 · see citing works

Widespread Activation and Consequences of Interleukin-1 in the Brain

Weiss, J. M., Quan, N., & Sundar, S. K. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb23117.x · Cited by 34 · see citing works

Modulation of the behavioural effects of Interleukin-1 in mice by Nitric Oxide

Bluthé, R., Sparber, S. B., & Dantzer, R. (1992) · Neuroreport · doi:10.1097/00001756-199202000-00022 · Cited by 30 · see citing works

Erratum: Cytokines in affective disorders and schizophrenia: new clinical and genetic findings

Prolo, P., & Licinio, J. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000555 · Cited by 21 · see citing works

Cytokine action in the brain

Plata‐Saláman, C. R., & Turrin, N. P. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000527 · Cited by 15 · see citing works

Stress-induced upregulation of pituitary interleukin-1 receptors is mediated by corticotropin releasing factor

Takao, T., Tojo, C., Nishioka, T., Makino, S., Hashimoto, K., & Souza, E. B. D. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00398-0 · Cited by 8 · see citing works

The Nobel Chronicles

Raju, T. N. K. (1998) · The Lancet · doi:10.1016/s0140-6736(05)60383-2 · Cited by 6 · see citing works

INTERLEUKIN-1: EFFECTS IN THE CENTRAL NERVOUS SYSTEM AND RELEVANCE TO AIDS

Weiss, J. M., & Sundar, S. K. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199201001-00342 · Cited by 3 · see citing works

A Meta-Analysis of Cytokines in Major Depression

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works

Glycogen synthase kinase-3 (GSK3): Inflammation, diseases, and therapeutics

Jope, R. S., Yuskaitis, C. J., & Beurel, E. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9128-5 · Cited by 774 · see citing works

Stress and the inflammatory response: A review of neurogenic inflammation

Black, P. H. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00021-1 · Cited by 687 · see citing works

Research and treatment approaches to depression

Wong, M.-L., & Licinio, J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072566 · Cited by 656 · see citing works

Major depression after breast cancer: a review of epidemiology and treatment

Fann, J. R., Thomas-Rich, A. M., Katon, W. J., Cowley, D., Pepping, M., McGregor, B. A., & Gralow, J. (2008) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.10.008 · Cited by 586 · see citing works

Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition

Wong, M.-L., Inserra, A., Lewis, M. D., Mastronardi, C. A., Leong, L., Choo, J., Kentish, S., Xie, P., Morrison, M., Wesselingh, S. L., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.46 · Cited by 568 · see citing works

Epidemiology of comorbid coronary artery disease and depression

Rudisch, B. E., & Nemeroff, C. B. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00587-0 · Cited by 549 · see citing works

Cytokines as mediators of depression: what can we learn from animal studies?

Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459 · see citing works

Assessing African medicinal plants for efficacy and safety: pharmacological screening and toxicology

Fennell, C. W., Lindsey, K. L., McGaw, L. J., Sparg, S. G., Stafford, G. I., Elgorashi, E. E., Grace, O. M., & van Staden, J. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.05.012 · Cited by 457 · see citing works

Leukocyte Telomere Length in Major Depression: Correlations with Chronicity, Inflammation and Oxidative Stress - Preliminary Findings

Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017837 · Cited by 421 · see citing works

Relation of C-reactive protein to stroke, cognitive disorders, and depression in the general population: systematic review and meta-analysis

Kuo, H., Yen, C., Chang, C., Kuo, C.-K., Chen, J.-H., & Sorond, F. A. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70099-5 · Cited by 400 · see citing works

Role of Interleukin-6 in Depressive Disorder

Ting, E. Y.-C., Yang, A. C., & Tsai, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062194 · Cited by 391 · see citing works

Cytokine–serotonin interaction through IDO: a neurodegeneration hypothesis of depression

Myint, A.-M., & Kim, Y. K. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00207-x · Cited by 376 · see citing works

Effects of antidepressants on the production of cytokines

Kenis, G., & Maes, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702003164 · Cited by 370 · see citing works

Prenatal Depression, Prenatal Anxiety, and Spontaneous Preterm Birth: A Prospective Cohort Study Among Women With Early and Regular Care

Dayan, J., Creveuil, C., Marks, M. N., Conroy, S., Herlicoviez, M., Dreyfus, M., & Tordjman, S. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000244025.20549.bd · Cited by 356 · see citing works

Neuroplasticity and cellular resilience in mood disorders

Manji, H. K., Moore, G. J., Rajkowska, G., & Chen, G. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000811 · Cited by 339 · see citing works

Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy

Sutcigil, L., Oktenli, C., Musabak, U., Bozkurt, A., Cansever, A., Uzun, O., Sanisoglu, S. Y., Yesilova, Z., Ozmenler, N., Ozsahin, A., et al. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/76396 · Cited by 315 · see citing works

Depression and Other Mental Health Diagnoses Increase Mortality Risk After Ischemic Stroke

Williams, L. S., Ghose, S. S., & Swindle, R. W. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.6.1090 · Cited by 309 · see citing works

Increased Serum Levels of 8-Hydroxy-2′-Deoxyguanosine in Clinical Depression

Forlenza, M. J., & Miller, G. E. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000195780.37277.2a · Cited by 307 · see citing works

Depression gets old fast: do stress and depression accelerate cell aging?

Wolkowitz, O. M., Epel, E. S., Reus, V. I., & Mellon, S. H. (2010) · Depression and Anxiety · doi:10.1002/da.20686 · Cited by 298 · see citing works

Selected biomarkers of depression: what are the effects of cytokines and inflammation

Harsanyi, S., Kupcova, I., Danisovic, L., & Klein, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010578 · Cited by 299 · see citing works

Interleukin 18 in the CNS

Alboni, S., Cervia, D., Sugama, S., & Conti, B. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-9 · Cited by 301 · see citing works

Depression in patients with chronic renal disease

Kimmel, P. L. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00310-0 · Cited by 297 · see citing works

Polymorphisms in Inflammation-Related Genes Are Associated with Susceptibility to Major Depression and Antidepressant Response

Wong, M.-L., Dong, C., Maestre-Mesa, J., & Licinio, J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.59 · Cited by 295 · see citing works

Antidepressant activity of aqueous extracts of Curcuma longa in mice

Yu, Z. F., Kong, L., & Chen, Y. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00211-8 · Cited by 293 · see citing works

The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines

Spalletta, G., Bossù, P., Ciaramella, A., Bria, P., Caltagirone, C., & Robinson, R. G. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001879 · Cited by 293 · see citing works

Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines

Kunz-Ebrecht, S., Mohamed‐Ali, V., Feldman, P. J., Kirschbaum, C., & Steptoe, A. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00029-1 · Cited by 290 · see citing works

Should Depressive Syndromes Be Reclassified as “Metabolic Syndrome Type II”?

McIntyre, R. S., Soczynska, J. K., Konarski, J. Z., Woldeyohannes, H. O., Law, C. W. Y., Miranda, A., Fulgosi, D., & Kennedy, S. H. (2007) · Annals of Clinical Psychiatry · doi:10.1080/10401230701653377 · Cited by 277 · see citing works

Inflammatory T helper 17 cells promote depression-like behavior in mice

Beurel, E., Harrington, L. E., & Jope, R. S. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.09.021 · Cited by 254 · see citing works

Inflammation in Children and Adolescents With Neuropsychiatric Disorders: A Systematic Review

Mitchell, R. H. B., & Goldstein, B. I. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.11.013 · Cited by 241 · see citing works

The Molecular Neurobiology of Depression

Shelton, R. C. (2007) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.12.005 · Cited by 242 · see citing works

Plasma and Cerebrospinal Fluid Interleukin-6 Concentrations in Posttraumatic Stress Disorder

Baker, D. G., Ekhator, N. N., Kasckow, J. W., Hill, K. K., Zoumakis, E., Dashevsky, B. A., Chrousos, G. P., & Geracioti Jr., T. D. (2001) · Neuroimmunomodulation · doi:10.1159/000049028 · Cited by 238 · see citing works

Cerebrospinal fluid analysis in affective and schizophrenic spectrum disorders: Identification of subgroups with immune responses and blood–CSF barrier dysfunction

Bechter, K., Reiber, H., Herzog, S., Fuchs, D., Tumani, H., & Maxeiner, H. G. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.008 · Cited by 230 · see citing works

Anti-inflammatory properties of desipramine and fluoxetine

Roumestan, C., Michel, A., Bichon, F., Portet, K., Detoc, M., Henriquet, C., Jaffuel, D., & Mathieu, M. N. (2007) · Respiratory Research · doi:10.1186/1465-9921-8-35 · Cited by 229 · see citing works

Screening, Diagnosis, and Treatment of Depression in Patients with End-Stage Renal Disease

Cohen, S. D., Norris, L., Acquaviva, K., Peterson, R. A., & Kimmel, P. L. (2007) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.03951106 · Cited by 229 · see citing works

Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems

Gądek-Michalska, A., Tadeusz, J., Rachwalska, P., & Bugajski, J. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71527-5 · Cited by 225 · see citing works

From monoamines to genomic targets: a paradigm shift for drug discovery in depression

Wong, M., & Licinio, J. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1303 · Cited by 225 · see citing works

Social factors and individual vulnerability to chronic stress exposure

Bartolomucci, A., Palanza, P., Sacerdote, P., Panerai, A. E., Sgoifo, A., Dantzer, R., & Parmigiani, S. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.06.009 · Cited by 225 · see citing works

The plasma levels of interleukin-12 in schizophrenia, major depression, and bipolar mania: effects of psychotropic drugs.

Kim, Y.-K., Suh, I.-B., Kim, H., Han, C.-S., Lim, C.-S., Choi, S.-H., & Licinio, J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001084 · Cited by 224 · see citing works

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

Basso, A. M., Bratcher, N. A., Harris, R. R., Jarvis, M. F., Decker, M. W., & Rueter, L. E. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.10.018 · Cited by 224 · see citing works

Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells

Liu, D., Wang, Z., Liu, S., Wang, F., Zhao, S., & Hao, A. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.033 · Cited by 221 · see citing works

Faecalibacterium prausnitzii (ATCC 27766) has preventive and therapeutic effects on chronic unpredictable mild stress-induced depression-like and anxiety-like behavior in rats

Hao, Z., Wang, W., Guo, R., & Liu, H. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.02.025 · Cited by 242 · see citing works

Serotonin Regulates Osteoclast Differentiation Through Its Transporter

Battaglino, R. A., Fu, J., Späte, U., Ersoy, U., Joe, M., Sedaghat, L., & Stashenko, P. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.040606 · Cited by 215 · see citing works

Depression and anxiety and outcomes of coronary artery bypass surgery

Pignay-Demaria, V., Lespérance, F., Demaria, R., Frasure‐Smith, N., & Perrault, L. P. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)04391-6 · Cited by 214 · see citing works

Depressive disorders—is it time to endorse different pathophysiologies?

Antonijevic, I. A. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.04.004 · Cited by 207 · see citing works

Neuropsychiatric Disease and Toxoplasma gondii Infection

Henriquez, S., Brett, R. R., Alexander, J. K., Pratt, J. A., & Roberts, C. W. (2009) · NeuroImmunoModulation · doi:10.1159/000180267 · Cited by 208 · see citing works

Antioxidative enzymes and increased oxidative stress in depressive women

Kodydková, J., Vávrová, L., Zeman, M., Jirák, R., Macášek, J., Staňková, B., Tvrzická, E., & Žák, A. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.06.006 · Cited by 197 · see citing works

Th2 Cytokine Response in Major Depressive Disorder Patients before Treatment

Pavón, L., Sandoval-López, G., Eugenia Hernández, M., Loría, F., Estrada, I., Pérez, M., Moreno, J., Ávila, U., Leff, P., Antón, B., et al. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.08.014 · Cited by 187 · see citing works

Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Kunz, M., Ceresér, K. M. M., Goi, P. D., Fries, G. R., Teixeira, A. L., Fernandes, B. S., Belmonte-de-Abreu, P. S., Kauer‐Sant’Anna, M., Kapczinski, F. P., & Gama, C. S. (2011) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462011000300010 · Cited by 189 · see citing works

Cytokine and growth factor involvement in schizophrenia—support for the developmental model

Nawa, H., Takahashi, M., & Patterson, P. H. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000730 · Cited by 189 · see citing works

Minireview: Neuro-Immuno-Endocrine Modulation of the Hypothalamic-Pituitary-Adrenal (HPA) Axis by gp130 Signaling Molecules

Chesnokova, V., & Melmed, S. K. (2002) · Endocrinology · doi:10.1210/endo.143.5.8861 · Cited by 188 · see citing works

Assessment of a Multi-Assay, Serum-Based Biological Diagnostic Test for Major Depressive Disorder: A Pilot and Replication Study

Papakostas, G. I., Shelton, R. C., Kinrys, G., Henry, M. E., Bakow, B. R., Lipkin, S. H., Pi, B., Thurmond, L., & Bilello, J. A. (2013) · Molecular Psychiatry · doi:10.1038/mp.2011.166 · Cited by 180 · see citing works

Pharmacogenetics of antidepressant response

Porcelli, S., Drago, A., Fabbri, C., Gibiino, S., Calati, R., & Serretti, A. (2011) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100059 · Cited by 179 · see citing works

Constant Darkness Induces IL-6-Dependent Depression-Like Behavior through the NF- B Signaling Pathway

Monje, F. J., Cabatic, M., Divisch, I., Kim, E.-J., Herkner, K. R., Binder, B. R., & Pollak, D. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1537-11.2011 · Cited by 178 · see citing works

Cytokines, stress, and depressive illness

Anisman, H., & Merali, Z. (2002) · Brain, Behavior, and Immunity · doi:10.1016/s0889-1591(02)00009-0 · Cited by 225 · see citing works

Recent progress in animal modeling of immune inflammatory processes in schizophrenia: Implication of specific cytokines

Nawa, H., & Takei, N. (2006) · Neuroscience Research · doi:10.1016/j.neures.2006.06.002 · Cited by 174 · see citing works

Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer

Sephton, S. E., Dhabhar, F. S., Keuroghlian, A. S., Giese-Davis, J., McEwen, B. S., Ionan, A. C., & Spiegel, D. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.07.007 · Cited by 170 · see citing works

Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans

Licinio, J., O'Kirwan, F., Irizarry, K. J. L., Merriman, B., Thakur, S., Jepson, R., Lake, S. L., Tantisira, K. G., Weiss, S. T., & Wong, M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001587 · Cited by 168 · see citing works

Depression: a major, unrecognized risk factor for osteoporosis?

Cizza, G., Ravn, P., Chrousos, G. P., & Gold, P. W. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00407-6 · Cited by 168 · see citing works

Expression of toll-like receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder

Kéri, S., Szabó, C., & Kelemen, O. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.03.020 · Cited by 165 · see citing works

Association of seropositivity for influenza and coronaviruses with history of mood disorders and suicide attempts

Okusaga, O., Yolken, R. H., Langenberg, P., Lapidus, M., Arling, T. A., Dickerson, F. B., Scrandis, D. A., Severance, E., Cabassa, J. A., Balis, T., et al. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.09.029 · Cited by 163 · see citing works

Depression in End-Stage Renal Disease Patients: A Critical Review

Kimmel, P. L., Cukor, D., Cohen, S. D., & Peterson, R. A. (2007) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2007.07.007 · Cited by 164 · see citing works

Endotoxin- or pro-inflammatory cytokine-induced sickness behavior as an animal model of depression: focus on anhedonia

De La Garza, R. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.016 · Cited by 153 · see citing works

Association Study of the Interleukin-1beta (C-511T) Genetic Polymorphism with Major Depressive Disorder, Associated Symptomatology, and Antidepressant Response

Yu, Y. W. ‐., Chen, T., Hong, C., Chen, H.-M., & Tsai, S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300172 · Cited by 150 · see citing works

The role of IL-12 and TGF-β1 in the pathophysiology of major depressive disorder

Lee, K.-M., & Kim, Y.-K. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.03.015 · Cited by 150 · see citing works

Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients

Futamura, T., Toyooka, K., Iritani, S., Niizato, K., Nakamura, R., Tsuchiya, K., Someya, T., Kakita, A., Takahashi, H., & Nawa, H. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001081 · Cited by 146 · see citing works

Updating the mild encephalitis hypothesis of schizophrenia

Bechter, K. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.019 · Cited by 141 · see citing works

Association of Anhedonia With Recurrent Major Adverse Cardiac Events and Mortality 1 Year After Acute Coronary Syndrome

Davidson, K. W., Burg, M. M., Kronish, I. M., Shimbo, D., Dettenborn, L., Mehran, R., Vorchheimer, D. A., Clemow, L., Schwartz, J. E., & Rieckmann, N. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.36 · Cited by 138 · see citing works

Depression and osteoporosis: epidemiology and potential mediating pathways

Mezuk, B., Eaton, W. W., & Golden, S. H. (2008) · Osteoporosis International · doi:10.1007/s00198-007-0449-2 · Cited by 134 · see citing works

Brain-immune interactions and disease susceptibility

Marques-Deak, A., Cizza, G., & Sternberg, E. M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001643 · Cited by 132 · see citing works

Nutrition, Inflammation, and Cognitive Function

Wärnberǵ, J., Gómez‐Martínez, S., Romeo, J., Díaz, L. E., & Marcos, A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2008.03985.x · Cited by 131 · see citing works

Antidepressants Attenuate Increased Susceptibility to Colitis in a Murine Model of Depression

Varghese, A. K., Verdu, E. F., Berčík, P., Khan, W. I., Blennerhassett, P. A., Szechtman, H., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.007 · Cited by 128 · see citing works

Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging

Duda, P., Wiśniewski, J., Wójtowicz, T., Wójcicka, O., Jaskiewicz, M. R., Drulis‐Fajdasz, D., Rakus, D., McCubrey, J. A., & Gizak, A. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1526925 · Cited by 121 · see citing works

Distinguishing fatigue and depression in patients with cancer.

Jacobsen, P. B., Donovan, K. A., & Weitzner, M. A. (2003) · PubMed · doi:10.1016/s1084-3612(03)00049-2 · Cited by 122 · see citing works

Green tea consumption is associated with depressive symptoms in the elderly

Niu, K., Hozawa, A., Kuriyama, S., Ebihara, S., Guo, H., Nakaya, N., Ohmori‐Matsuda, K., Takahashi, H., Masamune, Y., Asada, M., et al. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28216 · Cited by 118 · see citing works

Cytokines and the aging brain – what we don't know might help us

Bodles, A. M., & Barger, S. W. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.011 · Cited by 120 · see citing works

Depressive symptoms in patients with chronic hepatitis C are correlated with elevated plasma levels of interleukin-1β and tumor necrosis factor-α

Loftis, J. M., Huckans, M. S., Ruimy, S., Hinrichs, D. J., & Hauser, P. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.11.001 · Cited by 117 · see citing works

Major Depression Is a Risk Factor for Low Bone Mineral Density: A Meta-Analysis

Yirmiya, R., & Bab, I. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.016 · Cited by 114 · see citing works

Further evidence for the depressive effects of cytokines: Anhedonia and neurochemical changes

Anisman, H., Kokkinidis, L., & Merali, Z. (2002) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00011-9 · Cited by 112 · see citing works

Allopregnanolone as a mediator of affective switching in reproductive mood disorders

Schiller, C. E., Schmidt, P. J., & Rubinow, D. R. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3599-x · Cited by 107 · see citing works

Anti-TNF-α Compounds as a Treatment for Depression

Uzzan, S., & Azab, A. N. (2021) · Molecules · doi:10.3390/molecules26082368 · Cited by 109 · see citing works

Acetylsalicylic acid accelerates the antidepressant effect of fluoxetine in the chronic escape deficit model of depression

Brunello, N., Alboni, S., Capone, G., Benatti, C., Blom, J. M. C., Tascedda, F., Kriwin, P., & Mendlewicz, J. (2006) · International Clinical Psychopharmacology · doi:10.1097/00004850-200607000-00004 · Cited by 104 · see citing works

The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder

Dubey, N., Hoffman, J. F., Schuebel, K., Yuan, Q., Martinez, P. E., Nieman, L. K., Rubinow, D. R., Schmidt, P. J., & Goldman, D. A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.229 · Cited by 103 · see citing works

The role of the cytokine network in psychological stress

Kim, Y., & Maes, M. H. J. (2003) · Acta Neuropsychiatrica · doi:10.1034/j.1601-5215.2003.00026.x · Cited by 103 · see citing works

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the neuroendocrine stress axis

Steenblock, C., Todorov, V., Kanczkowski, W., Eisenhofer, G., Schedl, A., Wong, M., Licinio, J., Bauer, M., Young, A. H., Gainetdinov, R. R., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0758-9 · Cited by 102 · see citing works

Untitled work

Streit (2005) · doi:10.1179/016164105x49463 · Cited by 100 · see citing works

Regulatory role of the cannabinoid CB2receptor in stress‐induced neuroinflammation in mice

Zoppi, S., Madrigal, J. L. M., Caso, J. R., García‐Gutiérrez, M. S., Manzanares, J., Leza, J. C., & García‐Bueno, B. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12607 · Cited by 99 · see citing works

Depression and bone mineral density: is there a relationship in elderly Asian men? Results from Mr. Os (Hong Kong)

Wong, S. Y. S., Lau, E. M. C., Lynn, H., Leung, P., Woo, J., Cummings, S., & ORWOLL, E. S. (2004) · Osteoporosis International · doi:10.1007/s00198-004-1730-2 · Cited by 98 · see citing works

The Association between Conventional Antidepressants and the Metabolic Syndrome

McIntyre, R. S., Park, K. Y., Law, C. W. Y., Sultan, F., Adams, A., Lourenço, M. T. C., Lo, A., Soczynska, J. K., Woldeyohannes, H. O., Alsuwaidan, M. T., et al. (2010) · CNS Drugs · doi:10.2165/11533280-000000000-00000 · Cited by 96 · see citing works

Neuroimmunomodulation in Major Depressive Disorder: Focus on Caspase 1, Inducible Nitric Oxide Synthase, and Interferon-Gamma

Inserra, A., Mastronardi, C. A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1359-3 · Cited by 95 · see citing works

REVIEW: Biological risk factors for late life depression

Tiemeier, H. W. (2003) · European Journal of Epidemiology · doi:10.1023/a:1025388203548 · Cited by 95 · see citing works

Depression and Stroke: Cause or Consequence?

Williams, L. S. (2005) · Seminars in Neurology · doi:10.1055/s-2005-923534 · Cited by 95 · see citing works

Chronic psychosocial stress down-regulates central cytokines mRNA

Bartolomucci, A., Palanza, P., Parmigiani, S., Pederzani, T., Merlot, É., Neveu, P. J., & Dantzer, R. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.009 · Cited by 94 · see citing works

Weight change and appetite disturbance as symptoms of adolescent depression: Toward an integrative biopsychosocial model

Maxwell, M. A., & Cole, D. A. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.01.007 · Cited by 95 · see citing works

Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats

Nishitani, N., Nagayasu, K., Asaoka, N., Yamashiro, M., Andoh, C., Nagai, Y., Kinoshita, H., Kawai, H., Shibui, N., Liu, B., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0254-y · Cited by 92 · see citing works

Plasma Concentrations of Interleukin-1β, Interleukin-6, Soluble Interleukin-2 Receptor and Tumor Necrosis Factor α of Depressed Patients in Japan

Kagaya, A., Kugaya, A., Takebayashi, M., Fukue, M., Saeki, T., Yamawaki, S., & Uchitomi, Y. (2001) · Neuropsychobiology · doi:10.1159/000054867 · Cited by 92 · see citing works

A multi‐component assessment model for monitoring training distress among athletes

Main, L. C., & Grove, B. (2009) · European Journal of Sport Science · doi:10.1080/17461390902818260 · Cited by 90 · see citing works

Autocrine Interleukin-10 Mediates Glucagon-Like Peptide-1 Receptor-Induced Spinal Microglial β-Endorphin Expression

Wu, H., Tang, X.-Q., Mao, X.-F., & Wang, Y. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1799-17.2017 · Cited by 87 · see citing works

Role of IL-1 in Poststroke Depressive-like Behavior in Mice

Craft, T. K. S., & DeVries, A. C. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.011 · Cited by 87 · see citing works

Common Genetic Contributions to Depressive Symptoms and Inflammatory Markers in Middle-Aged Men: The Twins Heart Study

Su, S., Miller, A. H., Snieder, H., Bremner, J. D., Ritchie, J., Maisano, C., Jones, L. R., Murrah, N. V., Goldberg, J. H., & Vaccarino, V. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31819082ef · Cited by 87 · see citing works

PERSPECTIVE

Licinio, J., & Wong, M.-L. (2014)

Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression

Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works

Review: the role of inflammation in depression.

Patel, A. J. (2013) · PubMed · Cited by 96 · see citing works

Depression: an inflammatory illness?: Figure 1

Krishnadas, R., & Cavanagh, J. (2012) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301779 · Cited by 392 · see citing works

Inflammatory mechanisms in major depressive disorder

Raedler, T. J. (2011) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32834b9db6 · Cited by 213 · see citing works