Effect of repetitive transcranial magnetic stimulation (rTMS) treatment of major depressive disorder (MDD) on cognitive control
Open accessAbstract
Background Major Depressive Disorder (MDD) is commonly accompanied by cognitive control dysfunction that may persist after remission of clinical symptoms with antidepressant medication treatment. Repetitive Transcranial Magnetic Stimulation (rTMS) is an effective treatment alternative for medication-resistant MDD. In this study, we investigated whether rTMS treatment had a beneficial effect not only on depressive symptoms, but on also cognitive control dysfunction. Methods 77 subjects with MDD received a 30-session treatment course of 10 Hz rTMS administered at the left dorsolateral prefrontal cortex (DLPFC). Treatment efficacy was assessed using the Inventory of Depressive Symptomatology Self-Rated (IDS-SR) before and after treatment, with clinical response defined as 50% or greater decrease in the IDS-SR score at treatment 30. Cognitive control function was assessed before and after treatment using the Stroop word-color interference task. We examined changes in Stroop accuracy and reaction time for congruent and incongruent trials, as well as in relation to changes in depressive symptoms. Results Performance accuracy improved particularly for the rTMS responders in the incongruent condition, with older subjects benefitting most from the rTMS treatment. Improvement in reaction times was positively associated with clinical improvement, especially in the incongruent condition. Limitations We used a single cognitive task in a naturalistic setting without control for individual…
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Cognitive improvements following rTMS have been observed in younger adults with depression across various domains including learning and memory, attention, executive function, and psychomotor processing speed.
“Cognitive improvements following rTMS have been observed in younger adults with depression across various domains including learning and memory,16–18 attention, 19 executive function19–24 and psychomotor processing speed.”
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“Depressive symptoms were assessed at baseline and weekly during the course of treatment with the 30-item Inventory of Depressive Symptomatology Self Report version (IDS-SR, Trivedi et al., 2004).”
MethodAn efficient and accurate new method for locating the F3 position for prefrontal TMS applications
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- Authors
- Corlier, J., Burnette, E., Wilson, A. C., Lou, J. J., Landeros, A., Minzenberg, M. J., & Leuchter, A. F.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Corlier, Juliana
- ORCID
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 265
- Pages
- 272-277
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W3000082129
- Cited by
- 53
- References
- 13
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 1
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 329 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Journal of Affective Disorders (acceptedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Neuromodulation Postdoctoral Scholar Fund
- National Institutes of Health
- Department of Defense
- CHDI Foundation
- NeuroSigma, Inc.
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- repetitive transcranial magnetic stimulation, major depressive disorder, cognitive control, dorsolateral prefrontal cortex, Stroop interference, psychomotor speed, treatment response, age differences
- MeSH terms
- Antidepressive Agents, Cognition, Major Depressive Disorder, Humans, Treatment Outcome, Prefrontal Cortex, Transcranial Magnetic Stimulation
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