Cognition as a target in major depression: new developments.

Solé, Brisa; Jiménez, Esther; Martinez-Aran, Anabel; Vieta, Eduard

doi:10.1016/j.euroneuro.2014.12.004

Cited by 68Treatment of Major DepressionSchizophrenia research and treatmentTryptophan and brain disorders

Cognition as a target in major depression: new developments.

Solé, Brisa, Jiménez, Esther, Martinez-Aran, Anabel, Vieta, Eduard·2015·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2014.12.004

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Abstract

Major depressive disorder (MDD) is a highly prevalent and disabling psychiatric illness often accompanied of cognitive dysfunction which may persist even when patients achieve clinical remission. Currently, cognitive deficits emerge as a potential target because they compromise the functional outcome of depressed patients. The aim of this study was to review data for several potential pharmacological treatments targeting cognition in MDD, resulting from monotherapy or adjunctive treatment. An extensive and systematic Pubmed/Medline search of the published literature until March 2014 was conducted using a variety of search term to find relevant articles. Bibliographies of retrieved papers were further examined for publications of interest. Searches were limited to articles available in English language. We describe studies using modafinil, lisdexamfetamine, ketamine, lanicemine, memantine, galantamine, donepezil, vortioxetine, intranasal oxytocin, omega-3, s-adenosyl-methionine, scopolamine and erythropoietin. From these articles, we determined that there are a number of promising new therapies, pharmacological agents or complementary medicines, but data are just emerging. Drugs and therapies targeting cognitive dysfunction in MDD should prove effective in improving specific cognitive domains and functioning, while ruling out pseudospecificity.

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Currently, no effective treatments have been developed to alleviate cognitive deficits associated with psychiatric or neurological disorders.
“Currently, no effective treatments have been developed to alleviate cognitive deficits associated with psychiatric or neurological disorders (Wallace et al., 2011; Keefe et al., 2013, 2014; Solé et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Solé et al., 2015

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Goeldner, C., Ballard, T. M., Knoflach, F., Wichmann, J., Gatti, S., & Umbricht, D. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.08.001 · Cited by 96 · see citing works
Ketamine Appears Associated With Better Word Recall Than Etomidate After a Course of 6 Electroconvulsive Therapies
McDaniel, W. W., Sahota, A. K., Vyas, B. V., Laguerta, N., Hategan, L. F., & Oswald, J. C. (2006) · Journal of Ect · doi:10.1097/00124509-200606000-00005 · Cited by 94 · see citing works
A randomized comparison of ketamine versus methohexital anesthesia in electroconvulsive therapy
Rasmussen, K. G., Kung, S., Lapid, M. I., Oesterle, T., Geske, J. R., Nuttall, G. A., Oliver, W. C., & Abenstein, J. P. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.12.027 · Cited by 94 · see citing works
Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled FMRI study
Pincus, D. (2010) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2010.00134 · Cited by 91 · see citing works
Antidepressant Augmentation Using theN-Methyl-<scp>d</scp>-Aspartate Antagonist Memantine: A Randomized, Double-Blind, Placebo-Controlled Trial
Smith, E. G., Deligiannidis, K. M., Ulbricht, C. M., Landolin, C. S., Patel, J. K., & Rothschild, A. J. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12m08252 · Cited by 82 · see citing works
The increasing burden of mental and neurological disorders
Catalá-López, F., Gènova-Maleras, R., Vieta, E., & Tabarés‐Seisdedos, R. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.04.001 · Cited by 79 · see citing works
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Oxytocin and socioemotional aging: current knowledge and future trends
Ebner, N. C., Maura, G. M., MacDonald, K., Westberg, L., & Fischer, H. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00487 · Cited by 78 · see citing works
Verbal memory as a mediator in the relationship between subthreshold depressive symptoms and functional outcome in bipolar disorder
Bonnín, C. D. M., González-Pinto, A., Solé, B., Reinares, M., González-Ortega, I., Alberich, S., Crespo, J. M., Salamero, M., Vieta, E., Martínez-Arán, A., et al. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.02.034 · Cited by 76 · see citing works
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Lisdexamfetamine Dimesylate Augmentation in Adults With Persistent Executive Dysfunction After Partial or Full Remission of Major Depressive Disorder
Madhoo, M., Keefe, R. S., Roth, R. M., Sambunaris, A., Wu, J., Trivedi, M. H., Anderson, C. S., & Lasser, R. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.334 · Cited by 74 · see citing works
Hypothalamic–pituitary–adrenocortical system dysregulation and new treatment strategies in depression
Schüle, C., Baghai, T. C., Eser, D., & Rupprecht, R. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.52 · Cited by 72 · see citing works
Erythropoietin: a candidate treatment for mood symptoms and memory dysfunction in depression
Miskowiak, K. W., Vinberg, M., Harmer, C. J., Ehrenreich, H., & Kessing, L. V. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2511-1 · Cited by 70 · see citing works
Functional remediation for patients with bipolar II disorder: Improvement of functioning and subsyndromal symptoms
Solé, B., Bonnín, C. D. M., Mayoral, M., Amann, B. L., Torres, I., González-Pinto, A. M., Jiménez, E., Crespo, J. M., Colom, F., Tabarés‐Seisdedos, R., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.05.010 · Cited by 64 · see citing works
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A Randomized Controlled Trial of the Efficacy and Safety of Lisdexamfetamine Dimesylate as Augmentation Therapy in Adults With Residual Symptoms of Major Depressive Disorder After Treatment With Escitalopram
Trivedi, M. H., Cutler, A. J., Richards, C., Lasser, R., Geibel, B. B., Gao, J., Sambunaris, A., & Patkar, A. A. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.13m08360 · Cited by 58 · see citing works
Randomized double‐blind placebo‐controlled donepezil augmentation in antidepressant‐treated elderly patients with depression and cognitive impairment: a pilot study
Pelton, G. H., Harper, O. L., Tabert, M. H., Sackeïm, H. A., Scarmeas, N., Roose, S. P., & Devanand, D. P. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1958 · Cited by 54 · see citing works
Differences in mechanism of action between current and future antidepressants.
Stahl, S. M., & Grady, M. M. (2003) · PubMed · Cited by 53 · see citing works
Intranasal oxytocin impedes the ability to ignore task-irrelevant facial expressions of sadness in students with depressive symptoms
Ellenbogen, M. A., Linnen, A.-M., Cardoso, C., & Joober, R. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.06.016 · Cited by 53 · see citing works
A double blind, placebo‐controlled pilot study of galantamine augmentation of antidepressant treatment in older adults with major depression
Holtzheimer, P. E., Meeks, T. W., Kelley, M. E., Mufti, M., Young, R., McWhorter, K., Vito, N., Chismar, R., Quinn, S., Dey, S., et al. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1951 · Cited by 50 · see citing works
Cognitive Impairment Following Electroconvulsive Therapy-Does the Choice of Anesthetic Agent Make a Difference?
MacPherson, R., & Loo, C. K. A. (2008) · Journal of Ect · doi:10.1097/yct.0b013e31815ef25b · Cited by 49 · see citing works
Effects of omega-3 fatty acid supplementation on mood and emotional information processing in recovered depressed individuals
Antypa, N., Smelt, A. H., Strengholt, A., & Van der Does, A. W. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111424928 · Cited by 48 · see citing works
Erythropoietin modulates neural and cognitive processing of emotional information in biomarker models of antidepressant drug action in depressed patients
Miskowiak, K. W., Favaron, E., Hafizi, S., Inkster, B., Goodwin, G. M., Cowen, P. J., & Harmer, C. J. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1842-7 · Cited by 40 · see citing works
The impact of galantamine on cognition and mood during electroconvulsive therapy: A pilot study
Matthews, J., Blais, M. A., Park, L., WELCH, C. A., Baity, M. R., Murakami, J. L., Sklarsky, K. G., Homberger, C. H., & D, M. F. M. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.06.002 · Cited by 37 · see citing works
A Double-blind, Placebo-Controlled Study of the Impact of Galantamine on Anterograde Memory Impairment During Electroconvulsive Therapy
Matthews, J., Siefert, C. J., Blais, M. A., Park, L. T., Siefert, C. J., WELCH, C. A., DuBois, C. M., van Nieuwenhuizen, A. O., Rooney, K., Seabrook, R. C., et al. (2013) · Journal of Ect · doi:10.1097/yct.0b013e31828b3523 · Cited by 32 · see citing works
Assessing Past Treatment History
Posternak, M. A., Young, D., Sheeran, T. F., Chelminski, I., Franklin, C. L., & Zimmerman, M. A. (2004) · The Journal of Nervous and Mental Disease · doi:10.1097/01.nmd.0000110280.19284.47 · Cited by 28 · see citing works
Using Measurement Strategies to Identify and Monitor Residual Symptoms
McIntyre, R. S. (2013) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.12084su1c.03 · Cited by 25 · see citing works
Galantamine as an Adjunctive Treatment in Major Depression
Elgamal, S., & MacQueen, G. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318172756c · Cited by 25 · see citing works
Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder
Levkovitz, Y., Alpert, J. E., Brintz, C., Mischoulon, D., & Papakostas, G. I. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.03.006 · Cited by 24 · see citing works
Exploiting N-Methyl-D-Aspartate Channel Blockade for a Rapid Antidepressant Response in Major Depressive Disorder
Blier, P. U. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.029 · Cited by 13 · see citing works
P.2.d.039 Functional remediation in bipolar II patients: improvement of functioning and subsyndromal symptoms
Solé, B., Bonnín, C. D. M., Mayoral, M., Amann, B. L., Torres, I., González-Pinto, A. M., Jiménez, E., Crespo, J. M., Colom, F., Tabarés‐Seisdedos, R., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(14)70697-2 · Cited by 5 · see citing works
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Ketamine abuse potential and use disorder
Liu, Y., Lin, D., Wu, B., & Zhou, W. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.05.016 · Cited by 256 · see citing works
Reinforcement learning in depression: a review of computational research
Chen, C., Takahashi, T., Nakagawa, S., Inoue, T., & Kusumi, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.05.005 · Cited by 233 · see citing works
Cognitive dysfunction in major depression and bipolar disorder: <scp>A</scp>ssessment and treatment options
MacQueen, G. M., & Memedovich, K. A. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12463 · Cited by 172 · see citing works
Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment
Kandola, A., Hendrikse, J., Lucassen, P. J., & Yücel, M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00373 · Cited by 155 · see citing works
“Consequentially, the importance of alleviating cognitive dysfunction to enhance the success of MDD treatment is increasingly being recognized (Solé et al., 2015; Bortolato et al., 2016).”
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The Prevalence, Measurement, and Treatment of the Cognitive Dimension/Domain in Major Depressive Disorder
McIntyre, R. S., Xiao, H. X., Syeda, K., Vinberg, M., Carvalho, A. F., Mansur, R. B., Maruschak, N., & Cha, D. S. (2015) · CNS Drugs · doi:10.1007/s40263-015-0263-x · Cited by 145 · see citing works
Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools
Ott, C. V., Bjertrup, A. J., Jensen, J. H., Ullum, H., Sjælland, R., Purdon, S. E., Vieta, E., Kessing, L. V., & Miskowiak, K. W. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.10.059 · Cited by 128 · see citing works
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A Systematic Review of Executive Function and Information Processing Speed in Major Depression Disorder
Nuño, L., Gómez‐Benito, J., Carmona, V. R., & Pino, Ó. (2021) · Brain Sciences · doi:10.3390/brainsci11020147 · Cited by 124 · see citing works
Cognition as a target in schizophrenia, bipolar disorder and depression
Martinez-Aran, A., & Vieta, E. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.007 · Cited by 101 · see citing works
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Cognitive enhancement treatments for bipolar disorder: A systematic review and methodological recommendations
Miskowiak, K. W., Carvalho, A. F., Vieta, E., & Kessing, L. V. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.08.011 · Cited by 97 · see citing works
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La medicina personalizada aplicada a la salud mental: la psiquiatría de precisión
Vieta, E. (2015) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2015.03.003 · Cited by 93 · see citing works
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Cognitive mediators of the relationship between adverse childhood experiences and adult psychopathology: A systematic review
Doorn, K. A., Kamsteeg, C., & Silberschatz, G. (2019) · Development and Psychopathology · doi:10.1017/s0954579419001317 · Cited by 86 · see citing works
Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism
Yan, T., He, B., Wan, S., Xu, M., Yang, H., Xiao, F., Bi, K., & Jia, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-07407-1 · Cited by 75 · see citing works
The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders
Abramova, O. V., Zorkina, Y., Ushakova, V. M., Zubkov, E. A., Morozova, A. Y., & Chekhonin, V. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102079 · Cited by 74 · see citing works
Cognitive dysfunction in major depression: From assessment to novel therapies
Atique-Ur-Rehman, H., & Neill, J. C. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.013 · Cited by 72 · see citing works
Treatment of neurocognitive symptoms in unipolar depression: A systematic review and future perspectives
Salagre, E., Solé, B., Tomioka, Y., Fernandes, B. S., Hidalgo-Mazzei, D., Garriga, M., Jimenez, E., Sanchez-Moreno, J., Vieta, E., & Grande, I. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.06.034 · Cited by 71 · see citing works
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Systematic review of randomized controlled trials of candidate treatments for cognitive impairment in depression and methodological challenges in the field
Miskowiak, K. W., Ott, C. V., Petersen, J. Z., & Kessing, L. V. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.09.641 · Cited by 69 · see citing works
Functional remediation: the pathway from remission to recovery in bipolar disorder
Vieta, E., & Torrent, C. (2016) · World Psychiatry · doi:10.1002/wps.20351 · Cited by 68 · see citing works
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Antidepressant and neurocognitive effects of serial ketamine administration versus ECT in depressed patients
Basso, L., Bönke, L., Aust, S., Gärtner, M., Heuser, I., Otte, C., Wingenfeld, K., Bajbouj, M., & Grimm, S. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.01.002 · Cited by 69 · see citing works
Treatment of Functional Impairment in Patients with Bipolar Disorder
Sánchez‐Moreno, J., Martínez‐Arán, A., & Vieta, E. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0752-3 · Cited by 64 · see citing works
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Targeting hypothalamic-pituitary-adrenal axis hormones and sex steroids for improving cognition in major mood disorders and schizophrenia: a systematic review and narrative synthesis
Soria, V., González-Rodríguez, A., Huerta‐Ramos, E., Usall, J., Cobo, J., Bioque, M., Barbero, J. D., García‐Rizo, C., Tost, M., Monreal, J. A., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.04.012 · Cited by 64 · see citing works
The effectiveness of high-frequency left DLPFC-rTMS on depression, response inhibition, and cognitive flexibility in female subjects with major depressive disorder
Asgharian Asl, F., & Vaghef, L. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.01.025 · Cited by 58 · see citing works
Targeting the microbiome-gut-brain axis for improving cognition in schizophrenia and major mood disorders: A narrative review
Bioque, M., González-Rodríguez, A., García‐Rizo, C., Cobo, J., Monreal, J. A., Usall, J., Soria, V., & Labad, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110130 · Cited by 58 · see citing works
Personalized medicine applied to mental health: Precision psychiatry
Vieta, E. (2015) · Revista de Psiquiatría y Salud Mental (English Edition) · doi:10.1016/j.rpsmen.2015.03.007 · Cited by 56 · see citing works
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Drugs, games, and devices for enhancing cognition: implications for work and society
Brühl, A. B., & Sahakian, B. J. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13040 · Cited by 56 · see citing works
Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data?
Puryear, C. B., Brooks, J. M., Tan, L. A., Smith, K. L., Li, Y., Cunningham, J. I., Todtenkopf, M. S., Dean, R. L., & Sánchez, C. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.007 · Cited by 56 · see citing works
Effect of repetitive transcranial magnetic stimulation (rTMS) treatment of major depressive disorder (MDD) on cognitive control
Corlier, J., Burnette, E., Wilson, A. C., Lou, J. J., Landeros, A., Minzenberg, M. J., & Leuchter, A. F. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.068 · Cited by 53 · see citing works
Mental health and legal representation for asylum seekers in the ‘legacy caseload’
Kenny, M. A., Procter, N. G., & Grech, C. (2016) · Cosmopolitan Civil Societies An Interdisciplinary Journal · doi:10.5130/ccs.v8i2.4976 · Cited by 50 · see citing works
Cognitive impairment in remitted and non-remitted depressive patients: A follow-up comparison between first and recurrent episodes
Roca, M., López-Navarro, E., Monzón, S., Vives, M., Garcı́a-Toro, M., García‐Campayo, J., Harrison, J., & Gili, M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.07.020 · Cited by 45 · see citing works
Cognitive performance in antidepressant-free recurrent major depressive disorder
Albert, K. M., Potter, G. G., McQuoid, D. R., & Taylor, W. D. (2018) · Depression and Anxiety · doi:10.1002/da.22747 · Cited by 45 · see citing works
Acute cognitive effects of single-dose intravenous ketamine in major depressive and posttraumatic stress disorder
Davis, M. T., DellaGiogia, N., Maruff, P., Pietrzak, R. H., & Esterlis, I. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01327-5 · Cited by 37 · see citing works
Psychological Aspects of Heart Failure
Moser, D. K., Arslanian‐Engoren, C., Biddle, M., Chung, M. L., Dekker, R. L., Hammash, M., Mudd‐Martin, G., Alhurani, A. S., & Lennie, T. A. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0799-5 · Cited by 39 · see citing works
Vortioxetina: una nueva alternativa en el trastorno depresivo mayor
Salagre, E., Grande, I., Solé, B., Sánchez‐Moreno, J., & Vieta, E. (2017) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2017.06.006 · Cited by 39 · see citing works
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Randomized Controlled Trials of Add-On Antidepressants in Schizophrenia
Terevnikov, V., Joffe, G., & Stenberg, J. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv049 · Cited by 37 · see citing works
Effects of erythropoietin on memory‐relevant neurocircuitry activity and recall in mood disorders
Miskowiak, K. W., Macoveanu, J., Vinberg, M., Assentoft, E., Randers, L., Harmer, C. J., Ehrenreich, H., Paulson, O. B., Knudsen, G. M., Siebner, H. R., et al. (2016) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12597 · Cited by 36 · see citing works
Piromelatine ameliorates memory deficits associated with chronic mild stress-induced anhedonia in rats
Fu, W., Xie, H., Laudon, M., Zhou, S., Tian, S., & You, Y. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4272-3 · Cited by 36 · see citing works
Thymol reverses depression-like behaviour and upregulates hippocampal BDNF levels in chronic corticosterone-induced depression model in female mice
Capibaribe, V. C. C., Mallmann, A. S. V., Lopes, I. S., Oliveira, I. C. M., de Oliveira, N. F., Chaves, R. D. C., Fernandes, M. L., de Araújo, M. A., da Silva, D. M. A., Valentim, J. T., et al. (2019) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13162 · Cited by 32 · see citing works
Cognitive functioning and lifetime major depressive disorder in UK Biobank
de Nooij, L., Harris, M. A., Adams, M. J., Clarke, T., Shen, X., Cox, S. R., McIntosh, A. M., & Whalley, H. C. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2020.24 · Cited by 31 · see citing works
Investigating the relationship between age of onset of depressive disorder and cognitive function
Eraydin, I. E., Mueller, C., Corbett, A., Ballard, C. G., Brooker, H. J., Wesnes, K. A., Aarsland, D., & Huntley, J. D. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4979 · Cited by 31 · see citing works
Vortioxetine: A new alternative for the treatment of major depressive disorder
Salagre, E., Grande, I., Solé, B., Sánchez‐Moreno, J., & Vieta, E. (2018) · Revista de Psiquiatría y Salud Mental (English Edition) · doi:10.1016/j.rpsmen.2018.02.005 · Cited by 29 · see citing works
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The reduction in glutamate release is predictive of cognitive and emotional alterations that are corrected by the positive modulator of AMPA receptors S 47445 in perinatal stressed rats
Morley‐Fletcher, S., Zuena, A. R., Mairesse, J., Gatta, E., Camp, G. V., Bouwalerh, H., Riozzi, B., Battaglia, G., Pittaluga, A., Olivero, G., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.03.018 · Cited by 26 · see citing works
Executive Dysfunction in Criminal Populations: Comparing Forensic Psychiatric Patients and Correctional Offenders
Shumlich, E. J., Reid, G. J., Hancock, M., & Hoaken, P. N. S. (2018) · International Journal of Forensic Mental Health · doi:10.1080/14999013.2018.1495279 · Cited by 25 · see citing works
Individuals with depression exhibiting a pro-inflammatory phenotype receiving omega-3 polyunsaturated fatty acids experience improved motivation-related cognitive function: Preliminary results from a randomized controlled trial
Giollabhui, N. M., Mischoulon, D., Dunlop, B. W., Kinkead, B. L., Schettler, P. J., Liu, R. T., Okereke, O. I., Lamon‐Fava, S., D, M. F. M., & Rapaport, M. H. (2023) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2023.100666 · Cited by 13 · see citing works
Differential Role of mGluR5 in Cognitive Processes in Posttraumatic Stress Disorder and Major Depression
Esterlis, I., DeBonee, S., Cool, R., Holmes, S. E., Baldassarri, S. R., Maruff, P. T., Pietrzak, R. H., & Davis, M. T. (2022) · Chronic Stress · doi:10.1177/24705470221105804 · Cited by 13 · see citing works
Transcriptomic analyses of humans and mice provide insights into depression
Li, H., 650223，中国, 中. 昆., Su, X., Zhang, L.-W., Zhang, C., Wang, L., Li, W., Yang, Y., Lv, L., Li, M., et al. (2020) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2020.174 · Cited by 14 · see citing works
Intranasal oxytocin alters attention to emotional facial expressions, particularly for males and those with depressive symptoms
Boyle, A., Johnson, A. P., & Ellenbogen, M. A. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105796 · Cited by 12 · see citing works
Do People With Depression Always Have Decreased Cognitive Processing Speed? Evidence through Electrophysiological Lens
Ahorsu, D. K., & Tsang, H. W. H. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000451 · Cited by 12 · see citing works
A continuum hypothesis of psychotomimetic rapid antidepressants
Haarsma, J., Harmer, C. J., & Tamm, S. (2021) · Brain and Neuroscience Advances · doi:10.1177/23982128211007772 · Cited by 12 · see citing works
Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats
Dagda, R. K., Dagda, R. Y., Vazquez‐Mayorga, E., Martinez, B., & Gallahue, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010690 · Cited by 9 · see citing works
The touchscreen operant platform for assessing cognitive functions in a rat model of depression
Tran, T. P., Christensen, H. L., Bertelsen, F., Bouzinova, E. V., Møller, A., & Wiborg, O. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.03.032 · Cited by 9 · see citing works
Effects of Smartphone Overuse on Perceived Cognitive Function, Fatigue, and Daytime Sleepiness among College Students
Jung, M. S., Ju, K. O., Song, M. S., & Lee, K. S. (2016) · Journal of the Korean Society of School Health · doi:10.15434/kssh.2016.29.3.245 · Cited by 8 · see citing works
Alamandine enhanced spatial memory in rats by reducing neuroinflammation and altering BDNF levels in the hippocampus and prefrontal cortex
Kılıç, A., Ipek, B. E., Tatonyan, S. C., Kilic, K., Demirci, H., Atalar, F., Üstünova, S., & Darıyerli, N. (2025) · Scientific Reports · doi:10.1038/s41598-025-95683-7 · Cited by 7 · see citing works
A pilot study of accelerated deep transcranial magnetic stimulation effects on cognitive functioning in patients diagnosed with treatment resistant major depressive disorder
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Authors: Solé, B., Jiménez, E., Martinez-Aran, A., & Vieta, E.
Affiliations: Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
Centro de Investigación Biomédica en Red de Salud Mental (ES)
Corresponding author: Vieta, Eduard
ORCID: Solé, Brisa
Jiménez, Esther
Vieta, Eduard
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2015-02
Volume: 25
Issue: 2
Pages: 231-247
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2014.12.004
OpenAlex: W1998887294
Semantic Scholar: fbb8f1d8ef286d3ab894f7223e3a92b0a61401ce
Cited by: 68
References: 103
Citations by year: 2026: 1 · 2025: 1 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 4 · 2016: 17 · 2015: 10
FWCI: 1.63
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: European Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Esther Koplowitz Centre (CEK)
Spanish Ministry of Economy and Competitiveness
Instituto de Salud Carlos III, CIBERSAM, the Spanish Ministry of Education
Comissionat per a Universitats i Recerca del DIUE de la Generalitat de Catalunya to the Bipolar Disorders Group
Brain & Behavior Research Foundation
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: major depressive disorder, cognitive impairment, cognitive enhancement, pharmacotherapy, adjunctive therapy, modafinil, lisdexamfetamine, ketamine, memantine, galantamine, donepezil, vortioxetine, intranasal oxytocin, omega-3 fatty acids, S-adenosylmethionine, scopolamine, erythropoietin
MeSH terms: Animals, Antidepressive Agents, Cognition, Cognition Disorders, Major Depressive Disorder, Humans, Randomized Controlled Trials as Topic, Nootropic Agents

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Cognition as a target in major depression: new developments.

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