Association between perinatal pain and postpartum depression: A systematic review and meta-analysis
Abstract
Introduction In recent years, clinical studies have shown that perinatal pain could increase the risk of postpartum depression, while such a conclusion appears controversial. Therefore, we conducted this systematic review and meta-analysis to explore the association between perinatal pain and postpartum depression, and to evaluate the effectiveness of epidural labor analgesia in reducing the risk of postpartum depression. Methods PubMed, Web of Science, Embase and Cochrane Library were searched from inception to Jan 30th, 2022. The effect size of the meta-analysis was calculated using odds ratio and 95 % confidence interval. Statistical analysis was performed using Stata 15.0 software. Results There were 19 studies included with a total of 96,378 patients. Among the included studies, 10 investigated the association between perinatal pain and the risk of postpartum depression, and 9 reported that between labor analgesia and the risk of postpartum depression. The results of meta-analysis showed that perinatal pain increased the risk of postpartum depression [OR = 1.43, 95% CI (1.23, 1.67), p Limitations Source of heterogeneity in the association between perinatal pain and PPD could not be identified due to the limitations of the original studies. There were mainly cohort studies included in the assessment for effectiveness of epidural analgesia in reducing the incidence of postpartum pain. Therefore, we look forward to more RCTs to confirm our results. Conclusion Perinatal pain…
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Effective pain relief through neuraxial anesthesia may reduce physiological stress responses and improve maternal satisfaction.
“Conversely, effective pain relief through neuraxial anesthesia may reduce physiological stress responses and improve maternal satisfaction.15,16”
Severe or inadequately controlled pain during childbirth can increase maternal stress, elevate circulating stress hormones, and negatively influence the perception of the birth experience.
“Severe or inadequately controlled pain during childbirth can increase maternal stress, elevate circulating stress hormones, and negatively influence the perception of the birth experience.15”
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Fagan, J., Dufour, S., Duet, S., Downs, E., Siddaiah, H., Viswanath, O., Shekoohi, S., & Kaye, A. (2026) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s579920
- Authors
- Mo, J., Ning, Z., Wang, X., Lv, F., Feng, J., & Pan, L.
- Affiliations
- Guangxi Medical University (CN)
- Corresponding author
- Pan, Linghui
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2022-09
- Volume
- 312
- Pages
- 92-99
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W4282923778
- Cited by
- 48
- References
- 7
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 13 · 2023: 6
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- perinatal pain, postpartum depression, epidural analgesia, labor analgesia, risk factors, perinatal mental health
- MeSH terms
- Analgesics, Female, Humans, Labor, Obstetric, Pregnancy, Analgesia, Epidural, Depression, Postpartum, Labor Pain, Pain Management
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