Epidemiology of maternal depression, risk factors, and child outcomes in low-income and middle-income countries
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Maternal depression, a non-psychotic depressive episode of mild to major severity, is one of the major contributors of pregnancy-related morbidity and mortality. Maternal depression (antepartum or post partum) has been linked to negative health-related behaviours and adverse outcomes, including psychological and developmental disturbances in infants, children, and adolescents. Despite its enormous burden, maternal depression in low-income and middle-income countries remains under-recognised and undertreated. In this Series paper, we systematically review studies that focus on the epidemiology of perinatal depression (ie, during antepartum and post-partum periods) among women residing in low-income and middle-income countries. We also summarise evidence for the association of perinatal depression with infant and childhood outcomes. This review is intended to summarise findings from the existing literature, identify important knowledge gaps, and set the research agenda for creating new generalisable knowledge pertinent to increasing our understanding of the prevalence, determinants, and infant and childhood health outcomes associated with perinatal depression. This review is also intended to set the stage for subsequent work aimed at reinforcing and accelerating investments toward providing services to manage maternal depression in low-income and middle-income countries.
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Psychological distress among perinatal women correlates with poor infant health outcomes.
“Psychological distress among perinatal women correlates with increased maternal morbidity and mortality rates (Khalifa et al., 2016; Oates, 2003), poor infant health outcomes (Gelaye et al., 2016), and adverse early childhood developmental trajectories encompassing cognitive, emotional, and developmental delays (Slomian et al., 2019), making it a substantial public health concern.”
From Developing and validating the Sierra Leone perinatal psychological distress scale through an emic-etic approach (2025) · cites this paper as Gelaye et al., 2016
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Insan, N., Weke, A., Rankin, J. M., & Forrest, S. (2022) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-04642-x · Cited by 62 · see citing works
The association between maternal cortisol and depression during pregnancy, a systematic review
Orta, O. R., Gelaye, B., Bain, P. A., & Williams, M. A. (2017) · Archives of Women s Mental Health · doi:10.1007/s00737-017-0777-y · Cited by 56 · see citing works
Kalra, H., Tran, T. D., Romero, L., Chandra, P. S., & Fisher, J. (2020) · Archives of Women s Mental Health · doi:10.1007/s00737-020-01024-0 · Cited by 56 · see citing works
- Authors
- Gelaye, B., Rondon, M. B., Araya, R., & Williams, M. A.
- Affiliations
- Harvard University (US)
- London School of Hygiene & Tropical Medicine (GB)
- Corresponding author
- Gelaye, Bizu
- Venue
- The Lancet Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 3
- Issue
- 10
- Pages
- 973-982
- ISSN
- 2215-0366 (ISSN-L)
- PMC
- PMC5155709
- OpenAlex
- W2520629525
- Cited by
- 1,155
- References
- 197
- Citations by year
- 2026: 94 · 2025: 151 · 2024: 138 · 2023: 183 · 2022: 152 · 2021: 154 · 2020: 137 · 2019: 68 · 2018: 50 · 2017: 26 · 2012: 1
- FWCI
- 7.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Lancet Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- LSHTM Research Online (London School of Hygiene and Tropical Medicine) (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institutes of Health (R01-HD-059835 and T37-MD000149)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Keywords
- maternal depression, perinatal depression, antenatal depression, postpartum depression, low- and middle-income countries, risk factors, infant outcomes, child outcomes, prevalence, maternal mental health services
- MeSH terms
- Depressive Disorder, Developing Countries, Female, Humans, Infant, Pregnancy, Risk Factors, Depression, Postpartum, Pregnant People
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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