Cited by 21Suicide and Self-Harm StudiesTryptophan and brain disordersTreatment of Major Depression

C-reactive protein (CRP) level in depressed patients with suicidal behavior: a systematic review and meta-analysis

Fatemian, Hossein, Moslemi, Hossein, Hosseini, Yasaman, Moshfeghinia, Reza·2024·Journal of Affective Disorders

Abstract

Introduction Suicidal behavior necessitates prompt diagnosis due to its severe consequences. C-reactive protein (CRP) levels may offer insights into its pathophysiology and aid in risk assessment, potentially enhancing preventive interventions and treatment strategies. The aim of this study is to assess the CRP levels in depressed patients with and without suicidal behavior.Methods Our systematic review was registered in Prospero (#CRD42024518477). We searched five databases (PubMed, Scopus, PsycINFO, Web of Science, and CINAHL Complete) for records in English from inception to February 2024. We included observational studies that measured CRP in depressed patients with and without suicidal behavior. We used the Newcastle-Ottawa Scale (NOS) to assess the quality of the included studies. We employed a random-effects model, and the statistical analysis was conducted using Stata software version 17.Results Initial 632 articles narrowed to 15 for systematic review. Fifteen studies with 3652 participants included. Fourteen studies involving 3387 depressed patients, 1269 with suicidal behavior, analyzed CRP levels. Suicidal patients exhibited higher CRP levels (SMD: 0.80 [0.37, 1.23]). Analysis of seven studies with 465 participants, including 200 depressed patients with suicidal behavior and 265 healthy controls, showed higher CRP levels in depressed patients (SMD: 1.58 [0.97, 2.19]).Conclusion In summary, our systematic review and meta-analysis of CRP levels in suicidal patients revealed that those with suicidal behavior exhibited higher CRP levels, suggesting possible implications for treatment approaches.

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Crossref · 10.1016/j.jad.2024.08.135

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  • Peripheral inflammatory activity reflected in elevated CRP, fibrinogen, and TRYCATs is higher among suicidal individuals than in psychiatric or healthy controls.

    “Early psychoneuroimmunology research established that peripheral inflammatory activity reflected in elevated C-reactive protein (CRP), fibrinogen, and tryptophan catabolites (TRYCATs) is higher among suicidal individuals than in psychiatric or healthy controls (74–76).”

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Authors
Fatemian, H., Moslemi, H., Hosseini, Y., & Moshfeghinia, R.
Affiliations
  • Shiraz University of Medical Sciences (IR)
  • Aja University of Medical Sciences (IR)
Corresponding author
  • Hosseini, Yasaman
  • Moshfeghinia, Reza
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2024-12
Volume
366
Pages
423-433
ISSN
0165-0327 (ISSN-L)
OpenAlex
W4401836430
Cited by
21
References
46
Citations by year
2026: 10 · 2025: 11
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
C-reactive protein, depression, suicidal behavior, inflammation, suicide risk assessment, biomarkers, depression pathophysiology
MeSH terms
C-Reactive Protein, Depression, Humans, Suicide, Attempted, Biomarkers, Suicidal Ideation

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