CoChat
Sign Up
Cited by 96Suicide and Self-Harm StudiesTryptophan and brain disordersTreatment of Major Depression

Increased CRP levels may be a trait marker of suicidal attempt

Courtet, Ph., Jaussent, I., Genty, C., Dupuy, A.M., Guillaume, S, Ducasse, D., Olié, E.·2015·European Neuropsychopharmacology
DOI 10.1016/j.euroneuro.2015.05.003
Open this paper in CoChat — free account

Abstract

Suicide is a leading cause of death worldwide. Identifying biomarkers will help enhance our understanding of suicidal pathophysiology and improve its prevention. Therefore, we investigated CRP levels in 600 depressed inpatients: 520 patients had a lifetime history of suicide attempts and 80 patients did not have any history of suicide attempts. For all patients, we assessed socio-demographic features, lifetime Axis I DSM-IV diagnoses, depression intensity, suicidal ideation, characteristics of suicidal history, and history of childhood trauma. The day following admission, fasting blood tests yielded samples collected for the measurement of high sensitivity hs-CRP. CRP levels were associated with a history of suicide attempts. The risk of suicide attempts increased with higher levels of CRP in a dose-response way before and after adjustments for age, gender, chronic diseases, addiction and anxiety comorbidities, antidepressants use, smoking status and sexual abuse. Noteworthy, the association between CRP levels and history of suicide attempts remained significant after having excluded patients with chronic diseases. There was no significant difference in CRP levels between patients who attempted suicide more or less than a week before plasma sampling, and no significant difference in CRP levels was evidenced between high vs low suicidal ideation. In conclusion, this is the first study suggesting that CRP may be a trait marker for suicidal vulnerability by associating CRP levels and a lifetime history of suicide attempts in depressed inpatients. Therefore, determining the inflammatory marker profile of individuals exhibiting suicidal behaviors could be relevant for anticipating behaviors and refining new therapeutic opportunities.

Integrity signals

Registry

Crossref · 10.1016/j.euroneuro.2015.05.003

Cites

46 of 46 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Peripheral inflammatory biomarkers linked to suicide risk include elevated CRP, neutrophil-to-lymphocyte ratio, proinflammatory interleukins, cytokines such as IL-1β and IL-6, TNF-α, TGF-β1, and VEGF, and low levels of anti-inflammatory IL-2, IL-4, and IFN-γ in suicidal individuals.

    “Peripheral inflammatory biomarkers linked to suicide risk include elevated C-reactive protein (CRP), neutrophil-to-lymphocyte ratio, proinflammatory interleukins (IL), cytokines that regulate the immune response (e.g., IL-1β and IL-6), tumor necrosis factor-α (TNF-α), tissue growth factor-β1 (TGF-β1), and vascular endothelial growth factor (VEGF) and low levels of the anti-inflammatory IL-2, IL-4,”

    From A brain-centric model of suicidal behavior (2020) · cites this paper as [195]

Cites

Flagged first, then by citations

1 of the 47 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Courtet, P., Jaussent, I., Genty, C., Dupuy, A. M., Guillaume, S., Ducasse, D., & Olié, E.
Affiliations
Inserm (FR)
Corresponding author
Ducasse, D.
ORCID
Venue
European Neuropsychopharmacology
Publisher
Elsevier BV
Published
2015-10
Volume
25
Issue
10
Pages
1824-1831
ISSN
0924-977X (ISSN-L)
DOI
10.1016/j.euroneuro.2015.05.003
OpenAlex
W1816875290
Cited by
96
References
47
Citations by year
2026: 3 · 2025: 10 · 2024: 11 · 2023: 12 · 2022: 10 · 2021: 15 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 1
FWCI
8.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
C-reactive protein, suicide attempts, suicidal ideation, depression, inflammatory markers, trait markers, childhood trauma, suicide prevention, hospitalized patients
MeSH terms
Adult, C-Reactive Protein, Depressive Disorder, Female, Humans, Inpatients, Male, Suicide, Attempted, Cohort Studies, Biomarkers, Comorbidity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review