Cited by 154Asthma and respiratory diseasesOccupational exposure and asthmaChronic Obstructive Pulmonary Disease (COPD) Research

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

The Prevalence of Severe Asthma and Low Asthma Control Among Danish Adults

von Bülow, Anna, Kriegbaum, Margit, Backer, Vibeke, Porsbjerg, Celeste·2014·The Journal of Allergy and Clinical Immunology In Practice

DOI 10.1016/j.jaip.2014.05.005

Open this paper in CoChat — free account

Abstract

Background The prevalence of severe asthma is unknown. However, international expert statements estimate that severe asthma represents 5% to 10 % of the entire asthma population.Objective Based on register data from a nationwide population, we wanted to investigate the prevalence of severe asthma, the extent of asthma control, and contact with specialist care.Methods A descriptive cross-sectional register study was performed. By using a nationwide prescription database, we identified current patients with asthma (age, 18-44 years) in 2010. Severity was classified as severe versus mild-moderate asthma according to the level of antiasthma treatment. We investigated prescription drug use, hospitalizations, emergency department visits, and outpatient clinic visits according to severity.Results Among a nationwide population, we identified 61,583 current patients with asthma. Based on the level of antiasthma treatment, 8.1% of identified patients was classified as having severe asthma. Low asthma control (dispensed prescriptions of prednisolone, emergency department visits, hospitalization, or excessive short-acting β₂-agonist use) was more frequent in subjects with severe asthma (36.4% vs 25.2%, P < .0001); 63.8% with severe asthma and low asthma control were not managed by specialist care. Patients with severe asthma with specialist contact more frequently had impaired asthma control compared with subjects not treated by a specialist (44.4% vs 33.1%, P < .0001).Conclusion Based on the level of treatment, 8.1% of a nationwide population of current patients with asthma was classified as having severe asthma. Low asthma control was more frequent among subjects with severe asthma, and only a minority had access to specialist care. There is room for optimizing asthma management, particularly among patients with severe disease.

Integrity signals

Registry

Crossref · 10.1016/j.jaip.2014.05.005

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION
PAUWELS, R. A. (1996) · Arerugī/Arerugi · doi:10.15036/arerugi.45.792 · Cited by 9,997
Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma
Program, P., & theDiagnosis, T. E. P. O. (1997) · Cited by 4,082
Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma–Summary Report 2007
(2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.029 · Cited by 2,181
British Guideline on the Management of Asthma
British Thoracic Society Scottish Intercollegiate Guidelines Network (2008) · Thorax · doi:10.1136/thx.2008.097741 · Cited by 2,023
An Official American Thoracic Society/European Respiratory Society Statement: Asthma Control and Exacerbations
Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P., Gibson, P. G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-060st · Cited by 1,938
Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study
Rabe, K. F., Vermeire, P., Soriano, J. B., & Maier, W. (2000) · European Respiratory Journal · doi:10.1183/09031936.00.16580200 · Cited by 1,024
Proceedings of the ATS Workshop on Refractory Asthma
(2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.6.ats9-00 · Cited by 912
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma
Bousquet, J., Mantzouranis, E., Cruz, A. A., Aït-Khaled, N., Baena-Cagnani, C. E., Bleecker, E. R., Brightling, C. E., Burney, P., Bush, A., Busse, W. W., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.07.019 · Cited by 741
The Danish prescription registries.
Gaist, D., Sørensen, H. T., & Hallas, J. (1997) · PubMed · Cited by 570
A new perspective on concepts of asthma severity and control
Taylor, D. R., Bateman, E. D., Boulet, L., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P., Gibson, P. G., de Jongste, J. C., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00155307 · Cited by 471

Flagged first, then by citations

Show all 50 references

Research works printed but not linked: 1

Chung, 1999, ERS Task Force: difficult/therapy-resistant asthma, Eur Respir J, 13, 1198

Sorted by citations

Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200
Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature
Volmer, T., Effenberger, T., Trautner, C., & Buhl, R. (2018) · European Respiratory Journal · doi:10.1183/13993003.00703-2018 · Cited by 322
Co‐morbidities in severe asthma: Clinical impact and management
Porsbjerg, C., & Menzies‐Gow, A. (2017) · Respirology · doi:10.1111/resp.13026 · Cited by 233
Utilization and Costs of Severe Uncontrolled Asthma in a Managed-Care Setting
Zeiger, R. S., Schatz, M. N., Dalal, A. A., Qian, L., Chen, W., Ngor, E. W., Suruki, R., & Kawatkar, A. A. (2015) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2015.08.003 · Cited by 164
Characterisation of patients with severe asthma in the UK Severe Asthma Registry in the biologic era
Jackson, D. J., Busby, J., Pfeffer, P., Menzies-Gow, A. N., Brown, T., Gore, R. B., Doherty, M., Mansur, A. H., Message, S. D., Niven, R. M., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2020-215168 · Cited by 161
Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis
Thyssen, J. P., Toft, P. B., Halling, A., Gislason, G., Skov, L., & Egeberg, A. (2017) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2017.03.003 · Cited by 152
Shadow cost of oral corticosteroids-related adverse events: A pharmacoeconomic evaluation applied to real-life data from the Severe Asthma Network in Italy (SANI) registry
Canonica, G. W., Colombo, G. L., Bruno, G. M., Matteo, S. D., Martinotti, C., Blasi, F., Bucca, C. B., Crimi, N., Paggiaro, P., Pelaia, G., et al. (2019) · World Allergy Organization Journal · doi:10.1016/j.waojou.2018.12.001 · Cited by 120
Asthma biomarkers in the age of biologics
Kim, H. L., Ellis, A. K., Fischer, D., Noseworthy, M., Olivenstein, R., Chapman, K. R., & Lee, J. (2017) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-017-0219-4 · Cited by 115
Severe Asthma in a General Population Study: Prevalence and Clinical Characteristics
Rönnebjerg, L., Axelsson, M., Kankaanranta, H., Bäckman, H., Rådinger, M., Lundbäck, B., & Ekerljung, L. (2021) · Journal of Asthma and Allergy · doi:10.2147/jaa.s327659 · Cited by 110
Systematic literature review of the clinical, humanistic, and economic burden associated with asthma uncontrolled by GINA Steps 4 or 5 treatment
Chen, S. H., Golam, S. M., Myers, J. A., Bly, C. A., Smolen, H. J., & Xu, X. P. (2018) · Current Medical Research and Opinion · doi:10.1080/03007995.2018.1505352 · Cited by 109
Prevalence, disease burden, and treatment reality of patients with severe, uncontrolled asthma in Japan
Nagase, H., Adachi, M., Matsunaga, K., Yoshida, A., 大古場知子, Hayashi, N., Emoto, K., & Tohda, Y. (2019) · Allergology International · doi:10.1016/j.alit.2019.06.003 · Cited by 108
Prevalence and management of severe asthma in primary care: an observational cohort study in Sweden (PACEHR)
Larsson, K., Ställberg, B., Lisspers, K., Telg, G., Johansson, G., Thuresson, M., & Janson, C. (2018) · Respiratory Research · doi:10.1186/s12931-018-0719-x · Cited by 100
“1% were reported to have severe asthma [11].”
BackgroundMethodInfluential
Severe asthma—A population study perspective
Bäckman, H., Jansson, S., Stridsman, C., Eriksson, B., Hedman, L., Eklund, B., Sandström, T., Lindberg, A., Lundbäck, B., & Rönmark, E. (2019) · Clinical & Experimental Allergy · doi:10.1111/cea.13378 · Cited by 107
Oral corticosteroid use, morbidity and mortality in asthma: A nationwide prospective cohort study in Sweden
Ekström, M. P., Nwaru, B. I., Hasvold, P., Wiklund, F., Telg, G., & Janson, C. (2019) · Allergy · doi:10.1111/all.13874 · Cited by 97
Associations of symptoms of anxiety and depression with health-status, asthma control, dyspnoea, dysfunction breathing and obesity in people with severe asthma
Stubbs, M. A., Clark, V. L., Gibson, P. G., Yorke, J., & McDonald, V. M. (2022) · Respiratory Research · doi:10.1186/s12931-022-02266-5 · Cited by 89
Importance of Early COPD in Young Adults for Development of Clinical COPD. Findings from the Copenhagen General Population Study
Çolak, Y., Afzal, S., Nordestgaard, B. G., Lange, P., & Vestbo, J. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202003-0532oc · Cited by 82
Potential Severe Asthma Hidden in UK Primary Care
Ryan, D. P., Heatley, H., Heaney, L. G., Jackson, D. J., Pfeffer, P., Busby, J., Menzies-Gow, A. N., Jones, R. C. M., Tran, T. N., Al-Ahmad, M. S., et al. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.11.053 · Cited by 74
Low-dose oral corticosteroids in asthma associates with increased morbidity and mortality
Skov, I. R., Madsen, H., Henriksen, D. P., Andersen, J. H., Pottegård, A., & Davidsen, J. R. (2022) · European Respiratory Journal · doi:10.1183/13993003.03054-2021 · Cited by 70
Higher mortality of adults with asthma: A 15‐year follow‐up of a population‐based cohort
Lemmetyinen, R., Karjalainen, J., But, A., Renkonen, R., Pekkanen, J., Toppila-Salmi, S. K., & Haukka, J. K. (2018) · Allergy · doi:10.1111/all.13431 · Cited by 69
The Burden of Severe Asthma in France: A Case-Control Study Using a Medical Claims Database
BOURDIN, A. A., Fabry-Vendrand, C., Ostinelli, J., Ait-Yahia, M., Darnal, E., Bouée, S., Laurendeau, C., Bureau, I., Gourmelen, J., & CHOUAID, C. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.12.029 · Cited by 62
Severe Occupational Asthma: Insights From a Multicenter European Cohort
Vandenplas, O., Godet, J., Hurdubaea, L., Rifflart, C., Suojalehto, H., Walusiak‐Skorupa, J., Muñoz, X., Sastre, J., Klusáčková, P., Moore, V. C., et al. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.03.017 · Cited by 62
Development of the International Severe Asthma Registry (ISAR): A Modified Delphi Study
Bulathsinhala, L., Eleangovan, N., Heaney, L. G., Menzies-Gow, A. N., Gibson, P. G., Peters, M. J., Hew, M. J., van Boven, J. F. M., Lehtimäki, L. A., Ganse, E. H. V., et al. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2018.08.016 · Cited by 59
The real world effect of omalizumab add on therapy for patients with moderate to severe allergic asthma: The ASTERIX Observational study
Bhutani, M., Yang, W. H.-C., Hébert, J., de Takacsy, F., & Stril, J.-L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183869 · Cited by 58
Efficacy, adverse events, and inter-drug comparison of mepolizumab and reslizumab anti-IL-5 treatments of severe asthma – a systematic review and meta-analysis
Henriksen, D. P., Bødtger, U. C. S., Sidenius, K., Maltbæk, N., Pedersen, L., Madsen, H., Andersson, E. A., Norgaard, O., Klokker, L., & Chawes, B. (2018) · European Clinical Respiratory Journal · doi:10.1080/20018525.2018.1536097 · Cited by 57
Lost in the transition from pediatric to adult healthcare? Experiences of young adults with severe asthma
Ödling, M., Jonsson, M., Janson, C., Melén, E., Bergström, A., & Kull, I. (2019) · Journal of Asthma · doi:10.1080/02770903.2019.1640726 · Cited by 57
Defining asthma and assessing asthma outcomes using electronic health record data: a systematic scoping review
Sallakh, M. A. A., Vasileiou, E., Rodgers, S., Lyons, R. A., Sheikh, A., & Davies, G. A. (2017) · European Respiratory Journal · doi:10.1183/13993003.00204-2017 · Cited by 56
Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults
Porsbjerg, C. M., Ulrik, C. S., Skjold, T., Backer, V., Lærum, B. N., Lehman, S., Janson, C., Sandström, T., Bjermer, L. H., Dahlén, B., et al. (2018) · European Clinical Respiratory Journal · doi:10.1080/20018525.2018.1440868 · Cited by 58
Efficacy of azithromycin in severe asthma from the AMAZES randomised trial
Gibson, P. G., Yang, I. A., Upham, J. W., Reynolds, P. N., Hodge, S. J., James, A. L., Jenkins, C. R., Peters, M. J., Marks, G. B., Baraket, M., et al. (2019) · ERJ Open Research · doi:10.1183/23120541.00056-2019 · Cited by 54
International Severe Asthma Registry
Canonica, G. W., Alacqua, M., Altraja, A., Backer, V., Bel, E. H., Bjermer, L. H., Björnsdóttir, U. S., BOURDIN, A. A., Brusselle, G., Christoff, G., et al. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.10.051 · Cited by 53
Efficacy of omalizumab in children, adolescents, and adults with severe allergic asthma: a systematic review, meta-analysis, and call for new trials using current guidelines for assessment of severe asthma
Henriksen, D. P., Bødtger, U. C. S., Sidenius, K., Maltbæk, N., Pedersen, L., Madsen, H., Andersson, E. A., Nørgaard, O., Madsen, L. K., & Chawes, B. (2020) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-020-00442-0 · Cited by 53
Usage Patterns of Short-Acting β2-Agonists and Inhaled Corticosteroids in Asthma: A Targeted Literature Review
Amin, S., Soliman, M., McIvor, A., Cave, A., & Cabrera, C. S. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.03.013 · Cited by 49
Socioeconomic biases in asthma control and specialist referral of possible severe asthma
Håkansson, K. E. J., Backer, V., & Ulrik, C. S. (2021) · European Respiratory Journal · doi:10.1183/13993003.00741-2021 · Cited by 45
Insomnia symptoms and asthma control—Interrelations and importance of comorbidities
Sundbom, F., Malinovschi, A., Lindberg, E., Almqvist, C., & Janson, C. (2019) · Clinical & Experimental Allergy · doi:10.1111/cea.13517 · Cited by 45
Pregnancy complications, treatment characteristics and birth outcomes in women with atopic dermatitis in Denmark
Hamann, C. R., Egeberg, A., Wollenberg, A., Gislason, G., Skov, L., & Thyssen, J. P. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.15256 · Cited by 43
Severe asthma is related to high societal costs and decreased health related quality of life
Jansson, S., Bäckman, H., Andersson, M., Telg, G., Lindberg, A., Stridsman, C., Lundbäck, B., & Rönmark, E. (2020) · Respiratory Medicine · doi:10.1016/j.rmed.2019.105860 · Cited by 43
Use of High-Dose Inhaled Corticosteroids and Risk of Corticosteroid-Related Adverse Events in Asthma Findings From the NORDSTAR Cohort
von Bülow, A., Hansen, S., Sandin, P., Cooper, A., Ernstsson, O., Geale, K., Lehtimäki, L. A., Ulrik, C. S., Aarli, B. B., Ilmarinen, P., et al. (2025) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2025.01.023 · Cited by 42
Management of severe asthma: targeting the airways, comorbidities and risk factors
Gibson, P. G., & McDonald, V. M. (2017) · Internal Medicine Journal · doi:10.1111/imj.13441 · Cited by 41
Clinical and economic burden of severe asthma: A French cohort study
Nordon, C., Grimaldi‐Bensouda, L., Pribil, C., Nachbaur, G., Amzal, B., Thabut, G., Marthan, R., Aubier, M., Aubier, M., Crestani, B., et al. (2018) · Respiratory Medicine · doi:10.1016/j.rmed.2018.10.002 · Cited by 41
Living well with severe asthma
Stubbs, M. A., Clark, V. L., & McDonald, V. M. (2019) · Breathe · doi:10.1183/20734735.0165-2019 · Cited by 41
Prevalence and management of severe asthma in the Nordic countries: findings from the NORDSTAR cohort
Hansen, S., von Bülow, A., Sandin, P., Ernstsson, O., Janson, C., Lehtimäki, L. A., Kankaanranta, H., Ulrik, C. S., Aarli, B. B., Wahl, H. F., et al. (2023) · ERJ Open Research · doi:10.1183/23120541.00687-2022 · Cited by 40
Health care resource utilization and cost for asthma patients regularly treated with oral corticosteroids – a Swedish observational cohort study (PACEHR)
Janson, C., Lisspers, K., Ställberg, B., Johansson, G. S., Telg, G., Thuresson, M., Christensen, H. N., & Larsson, K. (2018) · Respiratory Research · doi:10.1186/s12931-018-0855-3 · Cited by 40
High prevalence of severe asthma in a large random population study
Mincheva, R., Ekerljung, L., Bossios, A., Lundbäck, B., & Lötvall, J. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.07.047 · Cited by 37
Efficacy and safety of mepolizumab in Japanese patients with severe eosinophilic asthma
Shimoda, T., Odajima, H., Okamasa, A., Kawase, M., Komatsubara, M., Mayer, B., Yancey, S. W., & Ortega, H. G. (2017) · Allergology International · doi:10.1016/j.alit.2016.11.006 · Cited by 36
Strategies to reduce corticosteroid-related adverse events in asthma
Heffler, E. M., Bagnasco, D., & Canonica, G. W. (2018) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000493 · Cited by 36
The role of antifungals in the management of patients with severe asthma
Rapeport, G., Ito, K., & Denning, D. W. (2020) · Clinical and Translational Allergy · doi:10.1186/s13601-020-00353-8 · Cited by 35
Severe asthma in Japan
Nagase, H. (2019) · Allergology International · doi:10.1016/j.alit.2019.02.004 · Cited by 33
The new era of add-on asthma treatments: where do we stand?
Calhoun, W. J., & Chupp, G. L. (2022) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-022-00676-0 · Cited by 37
Asthma and fixed airflow obstruction: Long‐term trajectories suggest distinct endotypes
Smith, B. M., Zhao, N., Olivenstein, R., Lemière, C., Hamid, Q. A., & Martin, J. G. (2020) · Clinical & Experimental Allergy · doi:10.1111/cea.13714 · Cited by 33
Beyond direct costs: individual and societal financial burden of asthma in young adults in a Danish nationwide study
Håkansson, K. E. J., Løkke, A., Ibsen, R., Hilberg, O., Backer, V., & Ulrik, C. S. (2023) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2022-001437 · Cited by 30
Association of Obesity and Severe Asthma in Adults
Olejnik, A. E., & Kuźnar-Kamińska, B. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13123474 · Cited by 31
Evaluation and Management of Difficult-to-Treat and Severe Asthma: An Expert Opinion From the Korean Academy of Asthma, Allergy and Clinical Immunology, the Working Group on Severe Asthma
Kim, B., Park, S., Ban, G., Kim, M., Lee, J., An, J. Y., Shim, J., Lee, Y., Won, H., Lee, H. Y., et al. (2020) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2020.12.6.910 · Cited by 29
Complete response to anti-interleukin-5 biologics in a real-life setting: results from the nationwide Danish Severe Asthma Register
Soendergaard, M. B., Hansen, S., Bjerrum, A., Hilberg, O., Johansson, S. L., Håkansson, K. E. J., Ingebrigtsen, T. S., Johnsen, C. R., Rasmussen, L. M., von Bülow, A., et al. (2022) · ERJ Open Research · doi:10.1183/23120541.00238-2022 · Cited by 29
Asthma Prevalence and Phenotyping in the General Population: The LEAD (Lung, hEart, sociAl, boDy) Study
Schiffers, C., Wouters, E. F. �., Breyer‐Kohansal, R., Buhl, R., Pohl, W., Irvin, C. G., Breyer, M., & Hartl, S. (2023) · Journal of Asthma and Allergy · doi:10.2147/jaa.s402326 · Cited by 32
Omalizumab for the treatment of patients with severe allergic asthma with immunoglobulin E levels above >1500 IU/mL
Menzella, F., Just, J., Sauerbeck, I. S., Mailaender, C., Saccheri, F., Thonnelier, C., Jaumont, X., & Mala, L. (2023) · World Allergy Organization Journal · doi:10.1016/j.waojou.2023.100787 · Cited by 29
The level of diagnostic assessment in severe asthma: A nationwide real-life study
von Bülow, A., Backer, V., Bødtger, U. C. S., Søes-Petersen, N. U., Assing, K. D., Skjold, T., & Porsbjerg, C. M. (2017) · Respiratory Medicine · doi:10.1016/j.rmed.2017.01.010 · Cited by 27
Allergic asthma is associated with increased risk of infections requiring antibiotics
Woehlk, C., von Bülow, A., Kriegbaum, M., Backer, V., & Porsbjerg, C. M. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.11.015 · Cited by 28
Prevalence of severe asthma according to the drug regulatory agency perspective: An Italian experience
Vianello, A., Caminati, M., Andretta, M., Menti, A. M., Tognella, S., Senna, G., & Esposti, L. D. (2019) · World Allergy Organization Journal · doi:10.1016/j.waojou.2019.100032 · Cited by 26
Real-life retrospective observational study to determine the prevalence and economic burden of severe asthma in Spain
Sicras‐Mainar, A., Capel, M., Navarro‐Artieda, R., Nuevo, J., Orellana, M. O., & Resler, G. (2020) · Journal of Medical Economics · doi:10.1080/13696998.2020.1719118 · Cited by 26
Significantly Higher Prevalence Rate of Asthma and Bipolar Disorder Co-Morbidity
Wu, M., Wang, H., Chen, Y., Lin, P., Wu, C.-K., & Tseng, P. (2016) · Medicine · doi:10.1097/md.0000000000003217 · Cited by 26
Asthma exacerbations: risk factors for hospital readmissions
González‐Barcala, F. J., Calvo-Álvarez, U., García-Sanz, M.-T., García-Couceiro, N., Martín‐Lancharro, P., Pose, A., Carreira, J. M., Moure-González, J.-D., Valdés, L., & Muñoz, X. (2017) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-017-1633-9 · Cited by 25
Clinical characteristics of the BREATHE cohort – a real-life study on patients with asthma and COPD
Backer, V., Klein, D. K., Bødtger, U. C. S., Romberg, K., Porsbjerg, C. M., Erjefalt, J. S., Kristiansen, K., Xu, R., Silberbrandt, A. W., Frøssing, L., et al. (2020) · European Clinical Respiratory Journal · doi:10.1080/20018525.2020.1736934 · Cited by 26
The Prevalence, Characteristics, and Patient Burden of Severe Asthma Determined by Using a Japan Health Care Claims Database
Sato, K., Ohno, T., Ishii, T., Ito, C., & Kaise, T. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2019.08.015 · Cited by 24
Prevalence and characterization of severe asthma in Hungary
Csoma, Z., Gál, Z., Gézsi, A., Herjavecz, I., & Szalai, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-66445-4 · Cited by 24
Tobacco Exposure and Efficacy of Biologic Therapy in Patients With Severe Asthma: A Nationwide Study From the Danish Severe Asthma Register
Soendergaard, M. B., Hansen, S., Bjerrum, A., von Bülow, A., Håkansson, K. E. J., Hilberg, O., Ingebrigtsen, T. S., Johnsen, C. R., Johansson, S. L., Rasmussen, L. M., et al. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.10.012 · Cited by 23
Long-Term Use of Short-Acting β2-Agonists in Patients With Adult-Onset Asthma
Vähätalo, I., Lehtimäki, L. A., Tuomisto, L. E., Karjalainen, J., Niemelä, O. J., Ilmarinen, P., & Kankaanranta, H. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.03.027 · Cited by 22
Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials
Chen, W., Reddel, H. K., FitzGerald, J. M., Beasley, R. W., Janson, C., & Sadatsafavi, M. (2023) · Respiratory Research · doi:10.1186/s12931-023-02409-2 · Cited by 22
Severe asthma trajectories in adults: findings from the NORDSTAR cohort
von Bülow, A., Hansen, S., Sandin, P., Ernstsson, O., Janson, C., Lehtimäki, L. A., Kankaanranta, H., Ulrik, C. S., Aarli, B. B., Geale, K., et al. (2023) · European Respiratory Journal · doi:10.1183/13993003.02474-2022 · Cited by 22
Asthma severity, nature or nurture: genetic determinants
Raby, B. A. (2019) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000758 · Cited by 22
Treatable Traits as a Pathway to Remission in Asthma
Farinha, I. T., Gibson, P. G., McDonald, V. M., & Heaney, L. G. (2025) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2025.05.002 · Cited by 20
Picturing asthma in Turkey: results from the Turkish adult asthma registry
Çelík, G., Aydın, Ö., Gokmen, D., Buhari, G. K., Sözener, Z. Ç., Gemicioğlu, B., Bulut, İ., Beyaz, Ş., Örçen, C., Özdemir, S. K., et al. (2023) · Journal of Asthma · doi:10.1080/02770903.2023.2206902 · Cited by 22
Perceptions of Severe Asthma and Asthma-COPD Overlap Syndrome Among Specialists: A Questionnaire Survey
Kim, S., Moon, J., Lee, J., Ban, G., Kim, S., Kim, M., Kim, J., Kim, M., Park, C. S., Park, S., et al. (2018) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2018.10.3.225 · Cited by 20
Oral corticosteroid-sparing effects of mepolizumab in severe eosinophilic asthma: evidence from randomized controlled trials and real-world studies
Casale, T. B., Burnette, A. F., BOURDIN, A. A., Howarth, P. H., Hahn, B. A., Stach-Klysh, A., & Khurana, S. (2022) · Therapeutic Advances in Respiratory Disease · doi:10.1177/17534666221107313 · Cited by 19
Roles of real-world evidence in severe asthma treatment: challenges and opportunities
Lee, Y., Lee, J., Park, S. Y., Lee, J.-H., Kim, J., Kim, H. J., Kim, S., Chung, K. F., & Song, W. (2022) · ERJ Open Research · doi:10.1183/23120541.00248-2022 · Cited by 18
Characteristics of Severe Asthma Patients and Predictors of Asthma Control in the Swiss Severe Asthma Registry
Jaun, F., Tröster, L. M., Giezendanne, S., Bridevaux, P., Charbonnier, F., Clarenbach, C. F., Gianella, P., Jochmann, A., Kern, L., Miedinger, D., et al. (2023) · Respiration · doi:10.1159/000533474 · Cited by 18
Schistosoma mansoni antigens alter activation markers and cytokine profile in lymphocytes of patients with asthma
de Almeida, T. V. V. S., Fernandes, J. S., Lopes, D. M., Andrade, L. S., Oliveira, S. C., Carvalho, E. M., Araújo, M. I., Cruz, Á. A., & Cardoso, L. S. (2016) · Acta Tropica · doi:10.1016/j.actatropica.2016.12.002 · Cited by 16
Epidemiology of patients with severe asthma in Japan: a nationwide descriptive study
Kimura, Y., Suzukawa, M., Jo, T., Hashimoto, Y., Kumazawa, R., Ishimaru, M., Matsui, H., Yokoyama, A., Tanaka, G., & Yasunaga, H. (2024) · ERJ Open Research · doi:10.1183/23120541.00122-2024 · Cited by 15
Spontaneous sputum discriminates inflammatory phenotypes in patients with asthma
Tanaka, A., Sato, H., Akimoto, K., Matsunaga, T., & Sagara, H. (2020) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2020.06.017 · Cited by 16
Associations of Breathing Pattern Disorder and Nijmegen Score With Clinical Outcomes in Difficult-to-Treat Asthma
Freeman, A. T., Abraham, S., Kadalayil, L., Varkonyi-Sepp, J., Ainsworth, B., Hudson-Colby, J. J., Barber, C., Dennison, P., Azim, A., Mistry, H. M., et al. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.11.036 · Cited by 14
Severe Asthma Global Evaluation (SAGE): An Electronic Platform for Severe Asthma
Denton, E. J., Hore‐Lacy, F., Radhakrishna, N., Gilbert, A., Tay, T. R., Lee, J., Dabscheck, E. J., Harvey, E. S., Bulathsinhala, L., Fingleton, J., et al. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.02.042 · Cited by 14
Clinical characteristics of patients with not well-controlled severe asthma in Japan: Analysis of the Keio Severe Asthma Research Program in Japanese population (KEIO-SARP) registry
Tanosaki, T., Kabata, H., Matsusaka, M., Miyata, J., Masaki, K., Mochimaru, T., Okuzumi, S., Kuwae, M., Watanabe, R., Suzuki, Y., et al. (2020) · Allergology International · doi:10.1016/j.alit.2020.06.002 · Cited by 14
Clinical Experience with Anti-IgE Monoclonal Antibody (Omalizumab) in Pediatric Severe Allergic Asthma—A Romanian Perspective
Berghea, C. E., Bălgrădean, M., Pavelescu, C., Cirstoveanu, C. G., Toma, C., Ionescu, M. D., & Bumbăcea, R. S. (2021) · Children · doi:10.3390/children8121141 · Cited by 14
Disease Control, Not Severity, Drives Job Absenteeism in Young Adults with Asthma – A Nationwide Cohort Study
Håkansson, K. E. J., Backer, V., & Ulrik, C. S. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s360776 · Cited by 14
Determinants of Severe Asthma – A Long-Term Cohort Study in Northern Sweden
Bäckman, H., Stridsman, C., Hedman, L., Rönnebjerg, L., Nwaru, B. I., Sandström, T., Kankaanranta, H., Lindberg, A., & Rönmark, E. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s376806 · Cited by 14
A call to action for improving clinical outcomes in patients with asthma
McIvor, A., & Kaplan, A. G. (2020) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-020-00211-x · Cited by 14
Real-world treatment and health care resource use among severe asthma patients in Japan
To, Y., Taguchi, Y., Shimazaki, T., Arima, K., Yu, E., Demiya, S., & Iwanaga, T. (2021) · Respiratory Investigation · doi:10.1016/j.resinv.2021.02.010 · Cited by 14
Combining the Mannitol Test and FeNO in the Assessment of Poorly Controlled Asthma
Porsbjerg, C. M., Sverrild, A., & Backer, V. (2015) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2015.02.005 · Cited by 13
Socioeconomic status is associated with healthcare seeking behaviour and disease burden in young adults with asthma – A nationwide cohort study
Håkansson, K. E. J., Backer, V., & Ulrik, C. S. (2022) · Chronic Respiratory Disease · doi:10.1177/14799731221117297 · Cited by 12
T2‐low severe asthma clinical spectrum and impact: The Greek PHOLLOW cross‐sectional study
Porpodis, Κ., Zias, N., Κostikas, Κ., Τzouvelekis, Α., Makris, M. P., Konstantinou, G. Ν., Ζervas, Ε., Loukides, S., Steiropoulos, P., Κatsoulis, Κ., et al. (2025) · Clinical and Translational Allergy · doi:10.1002/clt2.70035 · Cited by 12
Are recreational SCUBA divers with asthma at increased risk?
Ustrup, A. S., & Ulrik, C. S. (2016) · Journal of Asthma · doi:10.1080/02770903.2016.1263861 · Cited by 12
Efficacy of bronchial thermoplasty in patients with severe asthma
Madsen, H., Henriksen, D. P., Backer, V., Siersted, H. C., Bjerring, N., & Ulrik, C. S. (2019) · Journal of Asthma · doi:10.1080/02770903.2019.1678636 · Cited by 12
The burden of severe asthma in sub-Saharan Africa: Findings from the African Severe Asthma Project
Kirenga, B., Chakaya, J. M., Yimer, G., Nyale, G. M., Haile, T., Muttamba, W., Mugenyi, L., Katagira, W., Worodria, W. O., Aanyu-Tukamuhebwa, H., et al. (2024) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2024.100209 · Cited by 13
Long-Term Clinical Remission on Benralizumab Treatment in Severe Eosinophilic Asthma: A Four-Year Real-Life Study
Quarato, C. M. I., Tondo, P., Lacedonia, D., Soccio, P., Pescatore, D., Baccellieri, M. L., Lepore, G., Barbaro, M. P. F., & Scioscia, G. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14062075 · Cited by 11
NORDSTAR: paving the way for a new era in asthma research
Geale, K., Darabi, H., Lindh, M., Wahl, H. F., Ström, O., Cao, H., Alvares, L., Dodge, R., Loefroth, E., Altraja, A., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02476-2019 · Cited by 12
FASE-CPHG Study: identification of asthma phenotypes in the French Severe Asthma Study using cluster analysis
Rahérison, C., Parrat, É., Nocent-Eijnani, C., Mangiapan, G., Prudhomme, A., Oster, J.-P., de Vecchi, C. A., Maurer, C., Debieuvre, D., & Portel, L. (2021) · Respiratory Research · doi:10.1186/s12931-021-01723-x · Cited by 11
Clinical response and remission in patients treated with dupilumab for severe asthma: Results from the nationwide Danish Severe Asthma Register
Hansen, S., Håkansson, K. E. J., Soendergaard, M. B., Bjerrum, A., Schmid, J. M., Johansson, S. L., Rasmussen, L. M., Johnsen, C. R., von Bülow, A., Bonnesen, B., et al. (2025) · Respiratory Medicine · doi:10.1016/j.rmed.2025.108203 · Cited by 10
The Impact of Social Distancing in 2020 on Admission Rates for Exacerbations in Asthma: A Nationwide Cohort Study
Toennesen, L. L., Bonnesen, B., Sivapalan, P., Jordan, A. S., Saeed, M. I., Eklöf, J. V., Ulrik, C. S., Skaarup, K. G., Lassen, M. C. H., Biering‐Sørensen, T., et al. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.04.020 · Cited by 10
Adherence to inhaled corticosteroids in relation to quality of life and symptoms of anxiety and depression in asthma
Renzi-Lomholt, M., Håkansson, K. E. J., & Ulrik, C. S. (2022) · European Clinical Respiratory Journal · doi:10.1080/20018525.2022.2149920 · Cited by 10
The Danish National Database for Asthma: establishing clinical quality indicators
Hansen, S., Hoffmann‐Petersen, B., Sverrild, A., Bräuner, E. V., Lykkegaard, J., Bødtger, U. C. S., Agertoft, L., Korshoej, L., & Backer, V. (2016) · European Clinical Respiratory Journal · doi:10.3402/ecrj.v3.33903 · Cited by 11
BMI at school age and incident asthma admissions in early adulthood: a prospective study of 310,211 children
Ulrik, C. S., Lophaven, S., Andersen, Z. J., Sørensen, T. I. A., & Baker, J. L. (2018) · Clinical Epidemiology · doi:10.2147/clep.s156310 · Cited by 10
PAGE Study: Summary of a Study Protocol to Estimate the Prevalence of Severe Asthma in Spain Using Big Data Methods
Almonacid, C., Moreno, C. M., Gancedo, S. Q., Sánchez-Herrero, M. G., Gutiérrez, F. J. Á., Conejero, D. B., Cardona, V., & Soriano, J. B. (2020) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0483 · Cited by 10

Authors: von Bülow, A., Kriegbaum, M., Backer, V., & Porsbjerg, C.
Affiliations: University of Copenhagen (DK)
Bispebjerg Hospital (DK)
ORCID: Kriegbaum, Margit
Backer, Vibeke
Porsbjerg, Celeste
Venue: The Journal of Allergy and Clinical Immunology In Practice
Publisher: Elsevier BV
Published: 2014-11
Volume: 2
Issue: 6
Pages: 759-767.e2
ISSN: 2213-2198 (ISSN-L)
DOI: 10.1016/j.jaip.2014.05.005
OpenAlex: W2019613010
Cited by: 154
References: 50
Citations by year: 2026: 3 · 2025: 11 · 2024: 7 · 2023: 14 · 2022: 21 · 2021: 14 · 2020: 23 · 2019: 20 · 2018: 18 · 2017: 14 · 2016: 5 · 2015: 4
FWCI: 5.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: The Journal of Allergy and Clinical Immunology In Practice (publishedVersion)
PubMed (publishedVersion)
Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords: severe asthma, asthma prevalence, asthma control, specialist care, hospitalization, emergency department visits, adults, Denmark
MeSH terms: Adolescent, Adult, Age Factors, Ambulatory Care, Asthma, Cross-Sectional Studies, Denmark, Emergency Service, Hospital, Female, Health Resources, Hospitalization, Humans, Lung, Male, Drug Prescriptions, Referral and Consultation, Registries, Severity of Illness Index, Prevalence, Treatment Outcome, Drug Utilization Review, Anti-Asthmatic Agents, Health Care Surveys, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Prevalence of Severe Asthma and Low Asthma Control Among Danish Adults

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks