The DOI matches its Crossref record; 241 of the 241 references it cites were found in a registry or an index.
Severe Asthma in Children
Open accessAbstract
Severe asthma in children is characterized by sustained symptoms despite treatment with high doses of inhaled corticosteroids or oral corticosteroids. Children with severe asthma may fall into 2 categories, difficult-to-treat asthma or severe therapy-resistant asthma. Difficult-to-treat asthma is defined as poor control due to an incorrect diagnosis or comorbidities, or poor adherence due to adverse psychological or environmental factors. In contrast, treatment resistant is defined as difficult asthma despite management of these factors. It is increasingly recognized that severe asthma is a highly heterogeneous disorder associated with a number of clinical and inflammatory phenotypes that have been described in children with severe asthma. Guideline-based drug therapy of severe childhood asthma is based primarily on extrapolated data from adult studies. The recommendation is that children with severe asthma be treated with higher-dose inhaled or oral corticosteroids combined with long-acting β-agonists and other add-on therapies, such as antileukotrienes and methylxanthines. It is important to identify and address the influences that make asthma difficult to control, including reviewing the diagnosis and removing causal or aggravating factors. Better definition of the phenotypes and better targeting of therapy based upon individual patient phenotypes is likely to improve asthma treatment in the future.
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“Severe asthma is predominantly persistent in adults, but much more variable with rapidly evolving severe attacks in children, often remaining symptom-free between the attacks (75, 76).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [75]
In the citing paper
“Severe asthma is predominantly persistent in adults, but much more variable with rapidly evolving severe attacks in children, often remaining symptom-free between the attacks (75, 76).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [75]
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GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION
PAUWELS, R. A. (1996) · Arerugī/Arerugi · doi:10.15036/arerugi.45.792 · Cited by 9,997
Adherence to Long-Term Therapies: Evidence for Action
Geest, S. D., & Sabate, E. J. (2003) · European Journal of Cardiovascular Nursing · doi:10.1016/s1474-5151(03)00091-4 · Cited by 6,310
Expert Panel Report 2: Guidelines for the Diagnosis and Management of Asthma
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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Chung, K. F., Wenzel, S. E., Brozek, J. L., Bush, A., Castro, M., Sterk, P. J., Adcock, I. M., Bateman, E. D., Bel, E. H., Bleecker, E. R., et al. (2014) · European Respiratory Journal · doi:10.1183/09031936.00202013 · Cited by 3,926
Asthma and Wheezing in the First Six Years of Life
Martinez, F. D., Wright, A. L., Taussig, L. M., Holberg, C. J., Halonen, M., & Morgan, W. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199501193320301 · Cited by 3,823
Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma
Ortega, H. G., Liu, M. C., Pavord, I. D., Brusselle, G., FitzGerald, J. M., Chetta, A. A., Humbert, M. J. C., Katz, L. E., Keene, O. N., Yancey, S. W., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1403290 · Cited by 2,320
Pavord, I. D., Korn, S., Howarth, P. H., Bleecker, E. R., Buhl, R., Keene, O. N., Ortega, H. G., & Chanez, P. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60988-x · Cited by 2,238
(2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.09.029 · Cited by 2,181
Cluster analysis and clinical asthma phenotypes
Haldar, P., Pavord, I. D., Shaw, D. E., Berry, M. A., Thomas, M., Brightling, C. E., Wardlaw, A. J., & Green, R. H. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200711-1754oc · Cited by 1,987
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Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200
Ramratnam, S. K., Bacharier, L. B., & Guilbert, T. W. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.04.031 · Cited by 119
Aerts, R., Dujardin, S., Nemery, B., Van Nieuwenhuyse, A., Van Orshoven, J., Aerts, J.-M., Somers, B., Hendrickx, M., Bruffaerts, N., Bauwelinck, M., et al. (2020) · Environmental Research · doi:10.1016/j.envres.2020.109914 · Cited by 48
Metadata
- Authors
- Guilbert, T. W., Bacharier, L. B., & Fitzpatrick, A. M.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- St. Louis Children's Hospital (US)
- Emory University (US)
- Corresponding author
- Guilbert, Theresa W.
- Venue
- The Journal of Allergy and Clinical Immunology In Practice
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 2
- Issue
- 5
- Pages
- 489-500
- ISSN
- 2213-2198 (ISSN-L)
- PMC
- PMC4589165
- OpenAlex
- W2041272141
- Cited by
- 216
- References
- 241
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 22 · 2023: 21 · 2022: 22 · 2021: 17 · 2020: 35 · 2019: 32 · 2018: 21 · 2017: 12 · 2016: 8 · 2015: 8
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Allergy and Clinical Immunology In Practice (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health and Human Services
- Cystic Fibrosis Foundation
- American Academy of Allergy Asthma and Immunology
- AstraZeneca
- GlaxoSmithKline
- Teva Pharmaceutical Industries
- Regeneron Pharmaceuticals
- National Institutes of Health (HL098090)
- Centers for Disease Control and Prevention
- Genentech
- U.S. Public Health Service (NHLBI U10 HL098090, T72 MC00008-20-00, DHHS FAB 20166)
- National Heart, Lung, and Blood Institute (HL098090, U10HL109168, HL109168, U10HL098090, P01HL070831)
- National Institute of Nursing Research (R01NR012021, R01NR013700)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- severe asthma, childhood asthma, asthma phenotypes, asthma heterogeneity, clustering, asthma control, comorbidities, medication adherence, asthma action plan, asthma education, multidisciplinary care
- MeSH terms
- Adolescent, Adrenal Cortex Hormones, Adult, Asthma, Child, Child, Preschool, Diagnosis, Differential, Humans, Life Style, Patient Education as Topic, Respiratory Function Tests, Anti-Asthmatic Agents
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