The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease
Open accessAbstract
Background: Impairment in instrumental activities of daily living (IADL) leads to early loss in productivity and adds significant burden to caregivers. Executive dysfunction is thought to be an important contributor to functional impairment. The objective of this study was to investigate the relationship between executive function and IADL in a large cohort of well‐characterized normal older controls, mild cognitive impairment (MCI), and patients with mild Alzheimer's disease, separately as well as across the entire sample, while accounting for demographic, cognitive, and behavioral factors. Methods: Subjects with baseline clinical datasets (n = 793) from the Alzheimer's Disease Neuroimaging Initiative study (228 normal older controls, 387 MCI, 178 Alzheimer's disease) were included in the analysis. A multiple regression model was used to assess the relationship between executive function and IADL. Results: A multiple regression model, including diagnosis, global cognitive impairment, memory performance, and other covariates demonstrated a significant relationship between executive dysfunction and IADL impairment across all subjects (R2 = .60, P < .0001 for model; Digit Symbol, partial ß = −.044, P = .005; Trailmaking Test B–A, quadratic relation, P = .01). Similarly, an analysis using MCI subjects only yielded a significant relationship (R2 = .16, P < .0001 for model; Digit Symbol, partial ß = −.08, P = .001). Conclusions: These results suggest that executive dysfunction is a key contributor to impairment in IADL. This relationship was evident even after accounting for degree of memory deficit across the continuum of cognitive impairment and dementia.
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Citations
Cites
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882
Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980
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The processing-speed theory of adult age differences in cognition
Salthouse, T. A. (1996) · Psychological Review · doi:10.1037/0033-295x.103.3.403 · Cited by 5,902 · cited 1×
“Processing speed has been shown to relate to early cognitive decline in the elderly, well before dementia ensues [32].”
BackgroundJ Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844
Imaging β-amyloid burden in aging and dementia
Rowe, C. C., Ng, S., Ackermann, U., Gong, S. J., Pike, K., Savage, G., Cowie, T. F., Dickinson, K. L., Maruff, P., Darby, D., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000261919.22630.ea · Cited by 1,104
Mild cognitive impairment is related to Alzheimer disease pathology and cerebral infarctions
Bennett, D. A., Schneider, J. A., Bienias, J. L., Evans, D. A., & Wilson, R. S. (2005) · Neurology · doi:10.1212/01.wnl.0000152982.47274.9e · Cited by 537
Johnson, J. K., Lui, L.-Y., & Yaffe, K. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.10.1134 · Cited by 339
Cited by
Hill, N. T. M., Mowszowski, L., Naismith, S. L., Chadwick, V. L., Valenzuela, M., & Lampit, A. (2017) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.16030360 · Cited by 782
Christensen, J., Aarøe, L., Baekgaard, M., Herd, P., & Moynihan, D. P. (2020) · Public Administration Review · doi:10.1111/puar.13134 · Cited by 458
“Declines in executive functioning, even more than global cognitive declines, exert the largest negative impact on older adults, threatening their ability to manage their lives and live independently (Cahn-Weiner et al. 2000; Carlson et al. 1999; Johnson, Lui, and Yaffe 2007; Marshall et al. 2011).”
BackgroundWeiner, M. W., Veitch, D. P., Aisen, P. S., Beckett, L. A., Cairns, N. J., Cedarbaum, J., Green, R. C., Harvey, D., Jack, C. R., Jagust, W., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.11.001 · Cited by 348
Self-citationNowrangi, M. A., Lyketsos, C., Rao, V., & Munro, C. A. (2014) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.12070176 · Cited by 142
Donovan, N. J., Wadsworth, L. P., Lorius, N., Locascio, J. J., Rentz, D. M., Johnson, K. A., Sperling, R. A., & Marshall, G. A. (2014) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.03.006 · Cited by 106
Self-citation
Metadata
- Authors
- Marshall, G. A., Rentz, D. M., Frey, M. T., Locascio, J. J., Johnson, K. A., Sperling, R. A., & Initiative, A. D. N.
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2011-05
- Volume
- 7
- Issue
- 3
- Pages
- 300-308
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2158869838
- Cited by
- 437
- References
- 9
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- green
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