Systematic review of neuroimaging correlates of executive functioning: converging evidence from different clinical populations
Open accessAbstract
Executive functioning (EF) is an important cognitive domain that is negatively affected in a number of neuropsychiatric conditions. Neuroimaging methods have led to insights into the anatomical and functional nature of EF. The authors conducted a systematic review of the recent cognitive and neuroimaging literature to investigate how the neuroimaging correlates of EF compare between different diagnostic groups. The authors found that the frontal, parietal, and cerebellar lobes were most frequently associated with EF when comparing results from different clinical populations; the occipital lobe was not correlated with EF in any group. These findings suggest that individual disease processes affect circuits within an identifiable distributed network rather than isolated regions.
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The brain structures reduced in size in Down syndrome are responsible for executive function (frontal lobe, parietal lobe, and cerebellum) and declarative memory (hippocampus).
“For example, the brain structures that are reduced in size in DS are the structures that are responsible for executive function (frontal lobe, parietal lobe, and cerebellum) (Nowrangi et al., 2014) and memory – specifically declarative memory (hippocampus) (Scoville and Milner, 1957; Squire and Zolamorgan, 1991; Bliss and Collingridge, 1993).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Nowrangi et al., 2014
Thalamocortical circuits, and most circuits connecting deep brain structures to cortex, are inhibitory.
“thalamocortical circuits (and indeed most circuits connecting deep brain structures to cortex) are inhibitory (Nowrangi et al., 2014)”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Nowrangi et al., 2014
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Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
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“For example, the brain structures that are reduced in size in DS are the structures that are responsible for executive function (frontal lobe, parietal lobe, and cerebellum) (Nowrangi et al., 2014) and memory – specifically declarative memory (hippocampus) (Scoville and Milner, 1957; Squire and Zolamorgan, 1991; Bliss…”
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- Authors
- Nowrangi, M. A., Lyketsos, C., Rao, V., & Munro, C. A.
- Affiliations
- Johns Hopkins University (US)
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2014-04
- Volume
- 26
- Issue
- 2
- Pages
- 114-125
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- PMC
- PMC5171230
- OpenAlex
- W2139482163
- Cited by
- 142
- References
- 81
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 13 · 2023: 10 · 2022: 20 · 2021: 17 · 2020: 16 · 2019: 16 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 1
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P50AG005146, T32AG027668)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- executive function, neuroimaging correlates, frontal lobe, parietal lobe, cerebellum, occipital lobe, distributed neural networks, neuropsychiatric disorders, cognitive impairment
- MeSH terms
- Brain, Cognition Disorders, Humans, Neuropsychological Tests, Databases, Factual, Executive Function, Neuroimaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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