Cited by 142Neural and Behavioral Psychology StudiesHistorical and Modern Theater StudiesCognitive Functions and Memory

Systematic review of neuroimaging correlates of executive functioning: converging evidence from different clinical populations

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Nowrangi, Milap A., Lyketsos, Constantine, Rao, Vani, Munro, Cynthia A.·2014·The Journal of Neuropsychiatry and Clinical Neurosciences

Abstract

Executive functioning (EF) is an important cognitive domain that is negatively affected in a number of neuropsychiatric conditions. Neuroimaging methods have led to insights into the anatomical and functional nature of EF. The authors conducted a systematic review of the recent cognitive and neuroimaging literature to investigate how the neuroimaging correlates of EF compare between different diagnostic groups. The authors found that the frontal, parietal, and cerebellar lobes were most frequently associated with EF when comparing results from different clinical populations; the occipital lobe was not correlated with EF in any group. These findings suggest that individual disease processes affect circuits within an identifiable distributed network rather than isolated regions.

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Crossref · 10.1176/appi.neuropsych.12070176

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  • The brain structures reduced in size in Down syndrome are responsible for executive function (frontal lobe, parietal lobe, and cerebellum) and declarative memory (hippocampus).

    “For example, the brain structures that are reduced in size in DS are the structures that are responsible for executive function (frontal lobe, parietal lobe, and cerebellum) (Nowrangi et al., 2014) and memory – specifically declarative memory (hippocampus) (Scoville and Milner, 1957; Squire and Zolamorgan, 1991; Bliss and Collingridge, 1993).”

    From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Nowrangi et al., 2014

  • Thalamocortical circuits, and most circuits connecting deep brain structures to cortex, are inhibitory.

    “thalamocortical circuits (and indeed most circuits connecting deep brain structures to cortex) are inhibitory (Nowrangi et al., 2014)”

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Authors
Nowrangi, M. A., Lyketsos, C., Rao, V., & Munro, C. A.
Affiliations
Johns Hopkins University (US)
Venue
The Journal of Neuropsychiatry and Clinical Neurosciences
Published
2014-04
Volume
26
Issue
2
Pages
114-125
ISSN
  • 0895-0172 (ISSN-L)
  • 1545-7222
OpenAlex
W2139482163
Cited by
142
References
81
Citations by year
2026: 12 · 2025: 18 · 2024: 13 · 2023: 10 · 2022: 20 · 2021: 17 · 2020: 16 · 2019: 16 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 1
FWCI
0.42
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuropsychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (P50AG005146, T32AG027668)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
executive function, neuroimaging correlates, frontal lobe, parietal lobe, cerebellum, occipital lobe, distributed neural networks, neuropsychiatric disorders, cognitive impairment
MeSH terms
Brain, Cognition Disorders, Humans, Neuropsychological Tests, Databases, Factual, Executive Function, Neuroimaging

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