The DOI matches its Crossref record; 50 of the 52 references it cites were found in a registry or an index.
Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline
Open accessAbstract
Background: Longitudinal data on the role of atherosclerosis in different vessel beds in the etiology of cognitive impairment and dementia are scarce and inconsistent. Methods: Between 2003–2006, 2364 nondemented persons underwent computed tomography of the coronaries, aortic arch, extracranial, and intracranial carotid arteries to quantify atherosclerotic calcification. Participants were followed for incident dementia (n = 90) until April 2012. At baseline and follow‐up participants also underwent a cognitive test battery. Results: Larger calcification volume in all vessels, except in the coronaries, was associated with a higher risk of dementia. After adjustment for relevant confounders, extracranial carotid artery calcification remained significantly associated with a higher risk of dementia [hazard ratio per standard deviation increase in calcification volume: 1.37 (1.05, 1.79)]. Additional analyses for Alzheimer's disease only or censoring for stroke showed similar results. Larger calcification volumes were also associated with cognitive decline. Conclusions: Atherosclerosis, in particular in the extracranial carotid arteries, is related to a higher risk of dementia and cognitive decline.
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“In previous studies, atherosclerotic lesions in intra- and extra-cranial arteries were associated with cognitive impairment and even dementia [2,66,67].”
From Neuroprotective effect of SGLT2 inhibitors. (2021) · cites this paper as [66]
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“As demonstrated by another study, dementia occurred more frequently in patients with atherosclerotic calcifications in intra and extra-cranial arteries as opposed to coronary vessels [66].”
From Neuroprotective effect of SGLT2 inhibitors. (2021) · cites this paper as [66]
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Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,739
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,676
Quantification of coronary artery calcium using ultrafast computed tomography
Agatston, A. S., Janowitz, W. R., Hildner, F. J., Zusmer, N. R., Viamonte, M., & Detrano, R. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90282-t · Cited by 7,786
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880
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Pinto, T. C. C., Machado, L., Bulgacov, T. M., Rodrigues, A. L., da Costa, M. L. G., Ximenes, R. C. C., & Sougey, É. B. (2018) · International Psychogeriatrics · doi:10.1017/s1041610218001370 · Cited by 641
Epidemiology of Vascular Dementia
Wolters, F. J., & Ikram, M. A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.311908 · Cited by 445
Self-citationThe Rotterdam Study: 2016 objectives and design update
Albert Hofman, D., Brusselle, G., Murad, S. D., van Duijn, C. M., Franco, O. H., Goedegebure, A., Ikram, M. A., Klaver, C. C. W., Nijsten, T. E. C., Peeters, R. P., et al. (2015) · European Journal of Epidemiology · doi:10.1007/s10654-015-0082-x · Cited by 385
Self-citationNeuroprotective effect of SGLT2 inhibitors.
Pawlos, A., Broncel, M., Woźniak, E., & Gorzelak-Pabiś, P. (2021) · Molecules · doi:10.3390/molecules26237213 · Cited by 304
Hypertension and Cognitive Impairment: A Review of Mechanisms and Key Concepts
Canavan, M. D., & O'Donnell, M. J. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.821135 · Cited by 180
Metadata
- Authors
- Bos, D., Vernooij, M. W., de Bruijn, R. F. A. G., Koudstaal, P. J., Hofman, A., Franco, O. H., van der Lugt, A., & Ikram, M. A.
- Affiliations
- Department of Radiology Erasmus Medical Center Rotterdam The Netherlands
- Erasmus MC (NL)
- Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands
- Corresponding author
- Ikram, M. Arfan
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2014-08-21
- Volume
- 11
- Issue
- 6
- Pages
- 639
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2120316106
- Cited by
- 142
- References
- 52
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 13 · 2023: 17 · 2022: 14 · 2021: 12 · 2020: 17 · 2019: 11 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 5 · 2014: 1
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Erasmus Medisch Centrum
- Erasmus Universiteit Rotterdam
- European Commission
- Alzheimer's Association (NIRG‐08‐91391)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- atherosclerotic calcification, dementia
- MeSH terms
- Aged, Aorta, Thoracic, Calcinosis, Carotid Arteries, Cognition Disorders, Coronary Vessels, Dementia, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Netherlands, Prospective Studies, Risk, Tomography, X-Ray Computed, Stroke, Atherosclerosis
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