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Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline
Open accessAbstract
Background: Longitudinal data on the role of atherosclerosis in different vessel beds in the etiology of cognitive impairment and dementia are scarce and inconsistent. Methods: Between 2003–2006, 2364 nondemented persons underwent computed tomography of the coronaries, aortic arch, extracranial, and intracranial carotid arteries to quantify atherosclerotic calcification. Participants were followed for incident dementia (n = 90) until April 2012. At baseline and follow‐up participants also underwent a cognitive test battery. Results: Larger calcification volume in all vessels, except in the coronaries, was associated with a higher risk of dementia. After adjustment for relevant confounders, extracranial carotid artery calcification remained significantly associated with a higher risk of dementia [hazard ratio per standard deviation increase in calcification volume: 1.37 (1.05, 1.79)]. Additional analyses for Alzheimer's disease only or censoring for stroke showed similar results. Larger calcification volumes were also associated with cognitive decline. Conclusions: Atherosclerosis, in particular in the extracranial carotid arteries, is related to a higher risk of dementia and cognitive decline.
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“In previous studies, atherosclerotic lesions in intra- and extra-cranial arteries were associated with cognitive impairment and even dementia [2,66,67].”
From Neuroprotective effect of SGLT2 inhibitors. (2021) · cites this paper as [66]
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“As demonstrated by another study, dementia occurred more frequently in patients with atherosclerotic calcifications in intra and extra-cranial arteries as opposed to coronary vessels [66].”
From Neuroprotective effect of SGLT2 inhibitors. (2021) · cites this paper as [66]
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Grundy, S. M., Bilheimer, D. W., Chait, A., Clark, L. T., Denke, M. A., Havel, R. J., Hazzard, W. R., Hulley, S. B., Hunninghake, D. B., Kreisberg, R. A., et al. (1993) · JAMA · doi:10.1001/jama.269.23.3015 · Cited by 27,944
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Expert Panel on Detection, E. (2001) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.285.19.2486 · Cited by 26,011
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,739
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,676
Quantification of coronary artery calcium using ultrafast computed tomography
Agatston, A. S., Janowitz, W. R., Hildner, F. J., Zusmer, N. R., Viamonte, M., & Detrano, R. (1990) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(90)90282-t · Cited by 7,786
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
The global prevalence of dementia: a systematic review and metaanalysis.
Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., & Ferri, C. P. (2013) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2012.11.007 · Cited by 4,941
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411
Standards of medical care in diabetes—2013
American Diabetes Association (2013) · Diabetes Care · doi:10.2337/dc13-s011 · Cited by 4,369
Guidelines Committee (2003) · Journal of Hypertension · doi:10.1097/00004872-200306000-00001 · Cited by 3,015
Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
Zlokovic, B. V. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3114 · Cited by 2,969
Mancia, G., Rosei, E. A., Cífková, R., DeBacker, G., Erdine, S. E., Fagard, R., Farsang, C., Heagerty, A. M., Kawecka-Jaszcs, K., Kiowski, W., et al. (2003) · Lirias (KU Leuven) · doi:10.1097/01.hjh.0000059051.65882.32 · Cited by 2,601
Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline
Vermeer, S. E., Prins, N. D., den Heijer, T., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022066 · Cited by 2,313
Self-citationDonnan, G. A., Fisher, M., Macleod, M. R., & Davis, S. M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60694-7 · Cited by 2,288
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992
Experience from a multicentre stroke register: a preliminary report.
Hatano, S. (1976) · PubMed · Cited by 1,522
The Rotterdam Study: objectives and design update
Albert Hofman, D., Breteler, M. M. B., van Duijn, C. M., Krestin, G. P., Pols, H. A. P., Stricker, B. H. C., Tiemeier, H. W., Uitterlinden, A. G., Vingerling, J. R., & Witteman, J. C. M. (2007) · European Journal of Epidemiology · doi:10.1007/s10654-007-9199-x · Cited by 1,408
Sangiorgi, G., Rumberger, J., Severson, A. R., Edwards, W., Grégoire, J., Fitzpatrick, L., & Schwartz, R. S. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00443-9 · Cited by 1,075
Hofman, A., Ott, A., Breteler, M. M., Bots, M. L., Slooter, A. J., van Harskamp, F., van Duijn, C. N., Van Broeckhoven, C., & Grobbee, D. E. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09328-2 · Cited by 1,062
Carotid-Wall Intima–Media Thickness and Cardiovascular Events
Polak, J. F., Pencina, M. J., Pencina, K. M., O’Donnell, C. J., Wolf, P. A., & D’Agostino, R. B. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1012592 · Cited by 829
Prins, N. D., van Dijk, E. J., den Heijer, T., Vermeer, S. E., JOLLES, J., Koudstaal, P. J., Albert Hofman, D., & Breteler, M. M. B. (2005) · Brain · doi:10.1093/brain/awh553 · Cited by 754
Self-citation(2000) · PubMed · Cited by 683
Amieva, H., Jacqmin‐Gadda, H., Orgogozo, J., Carret, N. L., Helmer, C., Letenneur, L., Barberger‐Gateau, P., Fabrigoule, C., & Dartigues, J. (2005) · Brain · doi:10.1093/brain/awh451 · Cited by 470
Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study
Schrijvers, E. M. C., Verhaaren, B. F. J., Koudstaal, P. J., Hofman, A., Ikram, M. A., & Breteler, M. M. B. (2012) · Neurology · doi:10.1212/wnl.0b013e3182553be6 · Cited by 408
Self-citationPatterns and Risk Factors for Systemic Calcified Atherosclerosis
Allison, M., Criqui, M. H., & Wright, C. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000110786.02097.0c · Cited by 385
Dementia After Stroke: The Framingham Study
Ivan, C. S., Seshadri, S., Beiser, A., Au, R., Kase, C. S., Kelly-Hayes, M., & Wolf, P. A. (2004) · Stroke · doi:10.1161/01.str.0000127810.92616.78 · Cited by 369
White Matter Microstructural Integrity and Cognitive Function in a General Elderly Population
Vernooij, M. W., Ikram, M. A., Vrooman, H. A., Wielopolski, P. A., Krestin, G. P., Hofman, A., Niessen, W. J., Van der Lugt, A., & Breteler, M. M. B. (2009) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.5 · Cited by 335
Self-citationvan den Oord, S. C. H., Sijbrands, E. J. G., ten Kate, G. L., Klaveren, D. V., van Domburg, R. T., van der Steen, A. F. W., & Schinkel, A. F. L. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.01.025 · Cited by 317
Atherosclerosis and risk for dementia
van Oijen, M., de Jong, F. J., Witteman, J. C. M., Albert Hofman, D., Koudstaal, P. J., & Breteler, M. M. B. (2007) · Annals of Neurology · doi:10.1002/ana.21073 · Cited by 313
Self-citationThe Rotterdam Study: 2012 objectives and design update
Albert Hofman, D., van Duijn, C. M., Franco, O. H., Ikram, M. A., Janssen, H. L. A., Klaver, C. C. W., Kuipers, E. J., Nijsten, T. E. C., Stricker, B. H. C., Tiemeier, H. W., et al. (2011) · European Journal of Epidemiology · doi:10.1007/s10654-011-9610-5 · Cited by 290
Self-citationThe Mini-Mental State Examination in General Medical Practice: Clinical Utility and Acceptance
Tangalos, E. G., Smith, G. E., Ivnik, R. J., Petersen, R. C., Kokmen, E., Kurland, L. T., Offord, K. P., & Parisi, J. E. (1996) · Mayo Clinic Proceedings · doi:10.4065/71.9.829 · Cited by 260
Does vascular pathology contribute to Alzheimer changes?
Kalaria, R. N., Akinyemi, R., & Ihara, M. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.07.032 · Cited by 250
Alzheimer disease: new concepts on its neurobiology and the clinical role imaging will play
Jack, C. R. (2012) · Radiology · doi:10.1148/radiol.12110433 · Cited by 211 · cited 1×
“After adjustment for relevant confounders, extracranial carotid artery calcification remained significantly associated with a higher risk of dementia [hazard ratio per standard deviation increase in calcification volume: 1.37 (1.05, 1.79)].”
BackgroundInfluentialCalcified Atherosclerosis in Different Vascular Beds and the Risk of Mortality
Allison, M., Hsi, S., Wassel, C. L., Morgan, C. G., Ix, J. H., Criqui, M. H., & Criqui, M. H. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.235234 · Cited by 202
Intracranial Carotid Artery Atherosclerosis
Bos, D., van der Rijk, M. J. M., Geeraedts, T., Albert Hofman, D., Krestin, G. P., Witteman, J. C. M., van der Lugt, A., Ikram, M. A., & Vernooij, M. W. (2012) · Stroke · doi:10.1161/strokeaha.111.648667 · Cited by 188
Self-citationCalcification in Major Vessel Beds Relates to Vascular Brain Disease
Bos, D., Ikram, M. A., Elias‐Smale, S. E., Krestin, G. P., Albert Hofman, D., Witteman, J. C. M., van der Lugt, A., & Vernooij, M. W. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.232728 · Cited by 162
Self-citationRocca, W. A., Cha, R. H., Waring, S. C., & Kokmen, E. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009560 · Cited by 160
Wendell, C. R., Zonderman, A. B., Metter, E. J., Najjar, S. S., & Waldstein, S. R. (2009) · Stroke · doi:10.1161/strokeaha.109.557280 · Cited by 158
The association between physical activity and dementia in an elderly population: the Rotterdam Study
de Bruijn, R. F. A. G., Schrijvers, E. M. C., de Groot, K. A., Witteman, J. C. M., Albert Hofman, D., Franco, O. H., Koudstaal, P. J., & Ikram, M. A. (2013) · European Journal of Epidemiology · doi:10.1007/s10654-013-9773-3 · Cited by 145
Self-citationSerum Lipid Levels and the Risk of Intracerebral Hemorrhage: The Rotterdam Study
Wieberdink, R. G., Poels, M. M. F., Vernooij, M. W., Koudstaal, P. J., Albert Hofman, D., van der Lugt, A., Breteler, M. M. B., & Ikram, M. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.234948 · Cited by 140
Self-citationOdink, A. E., van der Lugt, A., Albert Hofman, D., Hunink, M. G. M., Breteler, M. M. B., Krestin, G. P., & Witteman, J. C. M. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.07.007 · Cited by 139
Coronary Artery Calcium, Brain Function and Structure: The AGES-Reykjavik Study
Vidal, J.-S., Sigurdsson, S., Jonsdottir, M. K., Eiriksdottir, G., Thorgeirsson, G., Kjartansson, O., Garcia, M. E., van Buchem, M. A., Harris, T. B., Gudnason, V., et al. (2010) · Stroke · doi:10.1161/strokeaha.110.579581 · Cited by 139
White matter volumes and periventricular white matter hyperintensities in aging and dementia
Smith, C. D., Snowdon, D. A., Wang, H., & Markesbery, W. R. (2000) · Neurology · doi:10.1212/wnl.54.4.838 · Cited by 137
Carotid Atherosclerosis and Prospective Risk of Dementia
Wendell, C. R., Waldstein, S. R., Ferrucci, L., O’Brien, R., Strait, J. B., & Zonderman, A. B. (2012) · Stroke · doi:10.1161/strokeaha.112.672527 · Cited by 111
Carotid atherosclerosis and 10-year changes in cognitive function
Zhong, W., Cruickshanks, K. J., Schubert, C. R., Acher, C. W., Carlsson, C. M., Klein, R., Klein, R., & Chappell, R. J. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2012.07.024 · Cited by 81
Elias‐Smale, S. E., Odink, A. E., Wieberdink, R. G., Albert Hofman, D., Hunink, M. G. M., Krestin, G. P., Koudstaal, P. J., Breteler, M. M. B., van der Lugt, A., & Witteman, J. C. M. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2010.06.037 · Cited by 54
Self-citationDeCarli, C. S. (2006) · Neurology · doi:10.1212/01.wnl.0000244911.16867.11 · Cited by 16
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Metadata
- Authors
- Bos, D., Vernooij, M. W., de Bruijn, R. F. A. G., Koudstaal, P. J., Hofman, A., Franco, O. H., van der Lugt, A., & Ikram, M. A.
- Affiliations
- Department of Radiology Erasmus Medical Center Rotterdam The Netherlands
- Erasmus MC (NL)
- Department of Epidemiology Erasmus Medical Center Rotterdam The Netherlands
- Corresponding author
- Ikram, M. Arfan
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2014-08-21
- Volume
- 11
- Issue
- 6
- Pages
- 639
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2120316106
- Cited by
- 142
- References
- 52
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 13 · 2023: 17 · 2022: 14 · 2021: 12 · 2020: 17 · 2019: 11 · 2018: 7 · 2017: 7 · 2016: 8 · 2015: 5 · 2014: 1
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
- RePub (Erasmus University Rotterdam) (submittedVersion)
- Funders
- Erasmus Medisch Centrum
- Erasmus Universiteit Rotterdam
- European Commission
- Alzheimer's Association (NIRG‐08‐91391)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- atherosclerotic calcification, dementia
- MeSH terms
- Aged, Aorta, Thoracic, Calcinosis, Carotid Arteries, Cognition Disorders, Coronary Vessels, Dementia, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Netherlands, Prospective Studies, Risk, Tomography, X-Ray Computed, Stroke, Atherosclerosis
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