Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study
Fiandaca, Massimo S., Kapogiannis, Dimitrios, Mapstone, Mark, Boxer, Adam, Eitan, Erez, Schwartz, Janice B., Abner, Erin L., Petersen, Ronald C. +3 more·2015·Alzheimer's & Dementia
Cited by (961)
Items 901–961 of 961
- Additional file 2 of Blood-based CNS regionally and neuronally enriched extracellular vesicles carrying pTau217 for Alzheimer’s disease diagnosis and differential diagnosisZhen Guo, Chen Tian, Shi, Yang, Song, Xue-Ru, Yin, Wei, Tao, Qing-Qing, Liu, Jie, Peng, Guo-Ping, Wu, Zhi-Ying, Wang, Yan-Jiang et al. · 2024 · Figshare
- Additional file 1 of Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse modelCarolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos J. Nogueras‐Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapić et al. · 2024 · Figshare
- Additional file 1 of Alzheimer’s disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesiclesGallart-Palau, Xavier, Guo, Xue, Serra, Aida, Sze, Siu Kwan · 2020 · Figshare
- Additional file 1 of Importance of extracellular vesicle secretion at the blood–cerebrospinal fluid interface in the pathogenesis of Alzheimer’s diseaseCharysse Vandendriessche, Sriram Balusu, Caroline Van Cauwenberghe, Brkic, Marjana, Marie J. Pauwels, Nele Plehiers, Arnout Bruggeman, Pieter Dujardin, Griet Van Imschoot, Elien Van Wonterghem et al. · 2021 · Figshare
- Additional file 1 of Delivering synaptic protein mRNAs via extracellular vesicles ameliorates cognitive impairment in a mouse model of Alzheimer’s diseaseCai, Huimin, Yana Pang, Ziye Ren, Xiaofeng Fu, Longfei Jia · 2024 · Figshare
- Additional file 1 of Immuno-digital invasive cleavage assay for analyzing Alzheimer’s amyloid ß-bound extracellular vesiclesKohei Yuyama, Sun, Hui, Yasuyuki Igarashi, Monde, Kenji, Takumi Hirase, Nakayama, Masato, Yoichi Makino · 2022 · Figshare
- Additional file 1 of Assessment of technical and clinical utility of a bead-based flow cytometry platform for multiparametric phenotyping of CNS-derived extracellular vesiclesAlexandra Brahmer, Carsten Geiß, Andriani Lygeraki, Elmo W. I. Neuberger, Theophilos Tzaridis, Tinh Thi Nguyen, Felix Luessi, Anne Régnier‐Vigouroux, Hartmann, Gunther, Simon, Perikles et al. · 2023 · Figshare
- Additional file 2 of Assessment of technical and clinical utility of a bead-based flow cytometry platform for multiparametric phenotyping of CNS-derived extracellular vesiclesAlexandra Brahmer, Carsten Geiß, Andriani Lygeraki, Elmo W. I. Neuberger, Theophilos Tzaridis, Tinh Thi Nguyen, Felix Luessi, Anne Régnier‐Vigouroux, Hartmann, Gunther, Simon, Perikles et al. · 2024 · Figshare
- Additional file 3 of Immuno-digital invasive cleavage assay for analyzing Alzheimer’s amyloid ß-bound extracellular vesiclesKohei Yuyama, Sun, Hui, Igarashi, Yasuyuki, Monde, Kenji, Takumi Hirase, Nakayama, Masato, Yoichi Makino · 2022 · Figshare
- Additional file 2 of Delivering synaptic protein mRNAs via extracellular vesicles ameliorates cognitive impairment in a mouse model of Alzheimer’s diseaseCai, Huimin, Yana Pang, Ziye Ren, Xiaofeng Fu, Longfei Jia · 2024 · Figshare
- Additional file 1 of The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic miceJing Di, Ibrar Ahmed Siddique, Li, Zizheng, Ghattas J. Malki, Simon Hornung, Dutta, Suman, Ian Hurst, Ella Ishaaya, Wang, Austin, Sally Tu et al. · 2021 · Figshare
- Isolation of CNS-Originating Extracellular Vesicles from Blood and Cell Culture MediaIbrar Ahmed Siddique, Megan Hong, Kimia Mohseni, Seyed Shahabadin Bidoki, Gal Bitan · 2026 · Neuromethods
- Extracellular Vesicles in Tauopathies: Mechanisms and ApplicationsVarun Nannuri, Ebaa Ababneh, Serena El Rayes, Jonhoi Smith, Kiminobu Sugaya, Jihe Zhao · 2026 · International Journal of Molecular Sciences
- Positive and negative selection of extracellular vesicle-based biomarkers: insights from L1CAM immunocapture and emerging immunodepletion strategiesAdam P. S. Bennett · 2026 · Open Research Europe
- Identification of stable reference genes in plasma astrocyte-derived exosomal mRNA for RT-qPCR analysis in Alzheimer's diseaseGuigui Guo, Yiwen Qu, Qiyao Wang, Zhihua Xiao, Qin Liu, Xianfei Zeng, Shouwen Chen · 2026 · Biochemical and Biophysical Research Communications
- Exosomes as biomarkers for disease diagnosisManu Bala, Netra Prasad Neupane · 2026 · Elsevier eBooks
- Decoding the implicit paradigm of exosome targeting blood brain barrier in neurodegenerative diseases: Molecular insight and therapeutic perspectiveRishika Koley, Sriparna De, Adrija Ghosh, Dipanjan Bhattacharjee, Ankan Mitra, Banashree Mondal, Agnish Pahari, Meghasri Nandi, Rachana Kanri, Sanjukta Dasgupta et al. · 2026 · In vitro models
- Les APP-CTFs au cœur du processus pathologique de la maladie d’Alzheimer : contribution du système lysosomal-autophagique et de la sécrétion exosomaleAnaïs Bécot · 2019 · theses.fr (ABES)
- Fibronectin type III domain-containing protein 5/irisin in extracellular vesicles is reduced in older individualsT. Hunter, Natalia M. Lyra e Silva, Guilherme B. de Freitas, Tayná Rody, Luis E Santos, Jieming Zhang, Alexis Bullock, Maria Carmela Tartaglia, Sheela A. Abraham, Chiara Nicolini et al. · 2026 · Brain Communications
- Recherches de biomarqueurs impliqués dans la maladie d’Alzheimer et associés à la protéine DYRK1A dans le syndrome de Down pour valider des traitements potentielsYuchen Gu · 2020 · theses.fr (ABES)
- Étude du rôle de la microglie dans la propagation de la protéine Tau : mise en place de nouveaux modèlesCharlotte Duwat · 2021 · theses.fr (ABES)
- Influence des lipides membranaires sur les interactions protéiques liées aux anomalies endolysosomales dans un modèle neuronal de la maladie d'AlzheimerMaxime Vigier · 2022 · theses.fr (ABES)
- Proteomic profiling of brain organoids and extracellular vesicles identifies early Alzheimer's disease biomarkers and drug response heterogeneityRachel J. Boyd, Daiyun Dong, Ram Sagar, Anton B. Iliuk, Waqar Ahmed, Xenia Androni, Anton P. Porsteinsson, Paul B. Rosenberg, Constantine George Lyketsos, Kenneth Whitaker Witwer et al. · 2026 · Alzheimer s & Dementia
- Bioproduction de vésicules extracellulaires à partir de cultures de sphéroïdes de cellules humaines en bioréacteurs à cuves agitéesThibaud Dauphin · 2024 · theses.fr (ABES)
- Application of Plasma Neuron-Derived Exosome-Based Multimodal Biomarkers in the Early Diagnosis of Alzheimer's DiseaseMin ZHONG · 2026 · Research Square
- Precision medicine for Alzheimer's disease in Down syndromeSonal Sukreet, Elise K. Kim, Melissa E. Petersen, Fan Zhang, Sid E. O’Bryant, Michael S. Rafii, Robert A. Rissman · 2026 · Alzheimer s & Dementia
- Neuron-Enriched Extracellular Vesicle MicroRNAs Reflect Hormone-Sensitive Neural Pathway Changes from Early to Late PerimenopauseRebekah Frye, Dana M. Lapato, Christopher Sikes-Keilp, JoAnn V. Pinkerton, Jennifer Payne, Vasily Yakovlev, Roxann Roberson‐Nay · 2026 · medRxiv
- Extracellular vesicles in neurodegenerative diseasesGeetanjali Singh, Sonima Prasad, Charan Singh, Arti Singh · 2026 · Elsevier eBooks
- Proteomic identification and validation of novel neuronal EV-based markers for Alzheimer’s disease biomarker discoveryWaqar Ahmed, Carlos J. Nogueras‐Ortiz, Ram Sagar, Daiyun Dong, Rachel J. Boyd, Pamela J. Yao, Anton B. Iliuk, Constantine George Lyketsos, Kenneth Whitaker Witwer, Dimitrios Kapogiannis et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Anti‐CRISPR Protein Regulates CRISPR/Cas12a Fusogenic‐Nanovesicle‐Based Platform for Extracellular Vesicle‐Encapsulated Non‐Nucleic Acid Target In‐Vesicle DetectionQiaoxuan Zhang, Yaling Li, Yuanzhe Li, Liqiao Han, Jun Yan, Min Zhan, Ting Liu, Peifeng Ke, Qiqin Wang, Xianzhang Huang · 2026 · Angewandte Chemie International Edition
- Anti‐CRISPR Protein Regulates CRISPR/Cas12a Fusogenic‐Nanovesicle‐Based Platform for Extracellular Vesicle‐Encapsulated Non‐Nucleic Acid Target In‐Vesicle DetectionQiaoxuan Zhang, Yaling Li, Yuanzhe Li, Liqiao Han, Jun Yan, Min Zhan, Ting Liu, Peifeng Ke, Qiqin Wang, Xianzhang Huang · 2026 · Angewandte Chemie
- Brain-Derived Extracellular Vesicle Subpopulations: from Bulk Measurements to Single-Entity AssaysShiyao Bai, Le Chen, Wei Zhang, Mingyuan Li, Han Liu, Xiaowen Huang, Lianqun Zhou, Weini Xin, Cheng Jiang, Chenzhong Li · 2026 · JACS Au
- Extracellular vesicles as biomarkers of disease progression and therapeutic response in patients with spinal muscular atrophyKathy L. Poulin, Charlotte A. René, Ian C. Smith, Panayiotis O. Vacratsis, Dylan E Burger, Hugh J. McMillan, Rashmi Kothary, Theodore J. Perkins, Jodi Warman‐Chardon, Robin J. Parks · 2026 · Molecular Therapy Advances
- Molecular and Structural Characterization Reveals Divergent Extracellular Vesicle Profiles Between Wild Type and Alzheimer’s Disease Cerebrocortical OrganoidsAnthony Balistreri, Natalie Turner, Jadon Compher, Mireya Almaraz, Akhil Prabhavalkar, Sachita Chittal, Sergio R. Labra, Kehinde Ezekiel, Christine Baal, Claudia Cedeño Kwong et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Exosomes as an emerging biological nanoplatform in the management of Alzheimer's disease: Breakthroughs and bottlenecksVikas Kamble, Kaustubh Ajit Kolekar, Swati Dabhole, Bushra Bashir, Popat Kumbhar, John Disouza, Prof Vandana B. Patravale · 2026 · Journal of Drug Delivery Science and Technology
- A combined neuronal extracellular vesicle-haematology panel for clinical stratification of Alzheimer’s disease and dementiaPraveena Ganji, Prasad Rao G, Nagalla Balakrishna, Rajesh V. Bendre, Amitabha Ghosh, Subhashani Prabhakar, Rukmini Mridula Kandadai, Sasidhar Venkata Manda · 2026 · Metabolic Brain Disease
- Cellular basis of medium flow-mediated reduction of Aβ neurotoxicity in cultured neuronsYoshiki Yagi, Sora Oda, Hitoshi Tatsumi · 2026 · Neuroscience Research
- Extracellular Vesicles in Stroke: Drivers of Brain–Body Network CrosstalkZ Y Xu, JIN Yu-Jia, Wei Zhang, Xiang-hua Ye, Feng Gao · 2026 · Translational Stroke Research
- Extracellular Vesicle Translational ResearchAnu Hardenia, Mina Zahiri, Hamed Afkhami, Maryam Sadat Bagheri, Mahdieh Ameri Shah Reza, Piao Yang, Mohsen Sheykhhasan · 2026 · Molecular and translational medicine
- Oral Microbial Extracellular Vesicles as Novel Mediators of Alzheimer’s Pathogenesis: A Critical Review of the Periodontal–Brain AxisSeyed Ebrahim Alavi, Hasan Ebrahimi Shahmabadi, Robert Matthew Love, Arun Kurumathur Vasudevan, Lavanya A. Sharma, Ajay Sharma · 2026 · Neurotoxicity Research
- Isolation and quantification of L1CAM/ATP1A3/GAP43-positive extracellular vesicles on a EVArray biochip as potential biomarkers for Parkinson’s diseaseYuwan Lin, Chunchen Liu, Zongtang Xu, Hui Shu, Siyuan Song, Zhongqiang Su, Weimin Li, Yuping Lin, H Y Chen, Huiyang Lu et al. · 2026 · Microchemical Journal
- Molecular biomarkers in diabetes-related neurological complications: current evidence and translational challengesAthena D. Myrou, Christos Voucharas, Christos G. Savopoulos · 2026 · Acta Diabetologica
- Diagnostic potential of exosomes in the neurodegenerative disorders and cancerNaveen Soni, Shweta Dongre, Bhawana Bissa · 2026 · International review of neurobiology
- Reinterpreting Circulating Neuron- and Oligodendrocyte-Derived Extracellular Vesicles for Non-invasive Monitoring of Neonatal Brain DevelopmentMasato Mitsuhashi · 2026 · Qeios
- Fungal extracellular vesicles as biomarkers in candidiasis: biogenesis, virulence, and CNS diagnostic applicationsJeongin Choi, Xuejin Wang, Jihyun Moon, Dae‐Kyum Kim, Hunsang Lee, Ji‐Eun Kim · 2026 · Frontiers in Cell and Developmental Biology
- Oxyberberine-nanoparticle attenuates the cognitive deficits in a transgenic mouse model of Alzheimer’s disease via modulating gut microbiota through suppressing CXCL10/CXCR3 pathwayYulin Wu, Qingqing Xu, Ze-hui Qin, Xue Wu, Zhen Hu, Wen Yang, Pei-Yao Ren, Yuan-Yang Tian, Zhi‐Xiu Lin, Yan‐Fang Xian · 2026 · Acta Pharmacologica Sinica
- Exosome research and neuroimaging techniques: Visualization analysis of development trends and research hotspotsQian Zhao, Tiantian Liu, Jian Xing, ZiXuan Kong, Dandan Hu, Miao Xia, Hongqiu Li, Zhenjun Chen, Lin Fei, Xinying Wang et al. · 2026 · Neural Regeneration Research
- Exosomes: emerging biomarkers and therapeutic potential in postoperative delirium and postoperative cognitive dysfunctionXinyu Li, Li Xu, Qiong Song, Qinjun Chu · 2026 · Frontiers in Cell and Developmental Biology
- Exosome-derived biomarkers as non-invasive tools in stroke, Parkinson’s disease, and Alzheimer’s diseaseAthar Talebi, Samira Nabili, Mobarakeh Alaei, Parisa Koohsarian, Ali Doostmohammadi, Mehdi Dadashpour · 2026 · Metabolic Brain Disease
- Dissecting Alzheimer's proteomic landscape through NULISA profiling of brain cell‐specific extracellular vesiclesAshish Kumar, Mitu Sharma, Yixin Su, Sangeeta Singh, Jordan E. Tanley, Ramon Casanova, Fang‐Chi Hsu, Suzanne Craft, Michelle M. Mielke, Timothy M. Hughes et al. · 2026 · Alzheimer s & Dementia
- Use of Neuronal-Enriched Extracellular Vesicles to Distinguish Cognitive Impairment Levels and Sex Differences in People with HIVNorina Tang, Fan Xia, Heather Freasier, Phyllis C. Tien, Marshall Jay Glesby, Daniel Merenstein, Audrey L. French, Heather McKay, Monica Maria Diaz, Igho Ofotokun et al. · 2026 · Cells
- Decoding disease progression: Biomarker in Alzheimer’s and Parkinson’s diseaseSangita Paul, Sanskriti Rai, Saroj Kumar · 2026 · Advances in pharmacology
- Cofilin 1 Is an Extracellular Vesicle‐Associated Plasma Biomarker of Parkinson's Disease in HumansDeepthy Chandran, Unnati Agrawal, Deepa Damayanthi, Divya T. Nair, Geetha Mandagini, Sruthi S. Nair, Deepti Narasimhaiah, Francis Boniface Fernandez, Poonam Singh Thakur, Cibin T. Raghavan et al. · 2026 · Annals of Neurology
- Extracellular vesicles in neurodegenerative diseases: A new frontier in diagnosis and therapySuleiman Ibrahim Mohammad, Asokan Vasudevan, Ghaleb Oriquat, Tushar B. Gajjar, Malathi Hanumanthayya, Sandeep Kumar Shukla, Navin Kumar Tailor, Mirza R. Baig, Omar Fadaam, Amir S. Abdul · 2026 · Behavioural Brain Research
- The emerging role of brain-derived microparticles in trauma-induced coagulopathy after traumatic brain injuryCai Xinrong, Han She, Mao Qingxiang · 2026 · Frontiers in Neurology
- Markers and Enrichment Strategies for Brain-Derived Extracellular Vesicles: Current Evidence, Limitations and Future DirectionsMazumder Adhish, Shubhankhi Dey, Shruti Gupta, Prasenjit Mitra · 2026 · NeuroMolecular Medicine
- Utility of extracellular vesicles in the diagnosis of central nervous system diseasesMinghao Wang, 杨俊文, Conghao Gao, Siyu Qu, Hongyu Mi, Yu Guo, Ting Gui, Zhibo Gai · 2026 · Frontiers in Neurology
- Advancing Exosome Research through Artificial Intelligence: Advancements and ApplicationsSonia Chadha · 2026 · Journal of Pharmacology and Experimental Therapeutics
- Toward objective brain monitoring of cancer-related cognitive impairment: an extracellular vesicle–based conceptual frameworkMasato Mitsuhashi · 2026 · Frontiers in Oncology
- Identification of candidate markers for the isolation of neuron-specific extracellular vesiclesTer-Ovanesyan, Dmitry, Whiteman, Sara, Gilboa, Tal, Kowal, Emma J. K., Trieu, Wendy, Iyer, Siddharth, Budnik, Bogdan, Babila, Clarissa May, Han, Chungmin, Vance, David et al. · 2026 · Nature Neuroscience
- Extracellular vesicles and Alzheimer’s disease: hotspots, trends, and future directions—a tri-database bibliometric analysisXi Wang, Bing-Wei Zhang · 2026 · Frontiers in Aging Neuroscience