Cited by 961Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchExtracellular vesicles in disease

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

Open access

Fiandaca, Massimo S., Kapogiannis, Dimitrios, Mapstone, Mark, Boxer, Adam, Eitan, Erez, Schwartz, Janice B., Abner, Erin L., Petersen, Ronald C., Federoff, Howard J., Miller, Bruce L., Goetzl, Edward J.·2015·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2014.06.008PMC PMC4329112

Open this paper in CoChat — free account

Abstract

Background: Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD. Methods: Blood exosomes obtained at one time‐point from patients with AD (n = 57) or frontotemporal dementia (FTD) (n = 16), and at two time‐points from others (n = 24) when cognitively normal and 1 to 10 years later when diagnosed with AD were enriched for neural sources by immunoabsorption. AD‐pathogenic exosomal proteins were extracted and quantified by enzyme‐linked immunosorbent assays. Results: Mean exosomal levels of total tau, P‐T181‐tau, P‐S396‐tau, and amyloid β 1–42 (Aβ1–42) for AD and levels of P‐T181‐tau and Aβ1–42 for FTD were significantly higher than for case‐controls. Step‐wise discriminant modeling incorporated P‐T181‐tau, P‐S396‐tau, and Aβ1–42 in AD, but only P‐T181‐tau in FTD. Classification of 96.4% of AD patients and 87.5% of FTD patients was correct. In 24 AD patients, exosomal levels of P‐S396‐tau, P‐T181‐tau, and Aβ1–42 were significantly higher than for controls both 1 to 10 years before and when diagnosed with AD. Conclusions: Levels of P‐S396‐tau, P‐T181‐tau, and Aβ1–42 in extracts of neurally derived blood exosomes predict the development of AD up to 10 years before clinical onset.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.jalz.2014.06.008

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
Sperling, R. A., Aisen, P. S., Beckett, L. A., Bennett, D. A., Craft, S., Fagan, A. M., Iwatsubo, T., Jack, C. R., Kaye, J., Montine, T. J., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.003 · Cited by 7,155
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
Rascovsky, K., Hodges, J. R., Knopman, D., Mendez, M. F., Kramer, J. H., Neuhaus, J., van Swieten, J. C., Seelaar, H., Dopper, E. G. P., Onyike, C. U., et al. (2011) · Brain · doi:10.1093/brain/awr179 · Cited by 5,221
Self-citation
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141
Self-citation
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
Villemagne, V. L., Burnham, S., Bourgeat, P., Brown, B., Ellis, K. A., Salvado, O., Szoeke, C., Macaulay, S. L., Martins, R., Maruff, P., et al. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70044-9 · Cited by 2,279
Alzheimer’s Dementia
Melnick, V. L., & Dubler, N. N. (1985) · Contemporary Issues in Biomedicine, Ethics, and Society · doi:10.1007/978-1-4612-5174-3 · Cited by 1,986
Alzheimer’s disease β-amyloid peptides are released in association with exosomes
Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., & Simons, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603838103 · Cited by 1,343
Plasma phospholipids identify antecedent memory impairment in older adults
Mapstone, M. E., Cheema, A. K., Fiandaca, M. S., Zhong, X., Mhyre, T. R., MacArthur, L. H., Hall, W. J., Fisher, S. G., Peterson, D. R., Haley, J. M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3466 · Cited by 1,060
Self-citation
Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease
Saman, S., Kim, W., Raya, M., Visnick, Y., Miro, S., Saman, S., Jackson, B., McKee, A. C., Alvarez, V. E., Lee, N. C. Y., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.277061 · Cited by 985

Show all 31 references

Sorted by citations

Items 501–600 of 961

Regulation of Hsa‐miR‐4639‐5p expression and its potential role in the pathogenesis of Parkinson's disease
He, L., Chen, Y., Lin, S., Shen, R., Pan, H., Zhou, Y., Wang, Y., Chen, S., & Ding, J. (2023) · Aging Cell · doi:10.1111/acel.13840 · Cited by 23
The Major Hypotheses of Alzheimer’s Disease: Related Nanotechnology-Based Approaches for Its Diagnosis and Treatment
Cáceres, C., Heusser, B., Garnham, A., & Moczko, E. (2023) · Cells · doi:10.3390/cells12232669 · Cited by 26
Approaches and Challenges in Characterizing the Molecular Content of Extracellular Vesicles for Biomarker Discovery
Kumari, S., Lausted, C. G., Scherler, K., Ng, A. H. C., Lü, Y., Lee, I., Hood, L., & Wang, K. (2024) · Biomolecules · doi:10.3390/biom14121599 · Cited by 25
The potential of exosomes in regenerative medicine and in the diagnosis and therapies of neurodegenerative diseases and cancer
Odehnalová, N., Šandriková, V., Hromádka, R., Skaličková, M., Dytrych, P., Hoskovec, D., Kejík, Z., Hajduch, J., Vellieux, F. M. D., Vašáková, M., et al. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1539714 · Cited by 28
Biomarker Organization in Circulating Extracellular Vesicles: New Applications in Detecting Neurodegenerative Diseases
Lim, C. Z. J., Natalia, A., Sundah, N. R., & Shao, H. (2020) · Advanced Biosystems · doi:10.1002/adbi.201900309 · Cited by 23
Neural extracellular vesicle-derived miR-17 in blood as a potential biomarker of subthreshold depression
Mizohata, Y., Toda, H., Koga, M., Saito, T., Fujita, M., Kobayashi, T., Hatakeyama, S., & Morimoto, Y. (2021) · Human Cell · doi:10.1007/s13577-021-00553-9 · Cited by 24
Biomarkers and Tools for Predicting Alzheimer’s Disease in the Preclinical Stage
Li, T.-R., Yang, Q. Z., Hu, X., & Han, Y. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210524153901 · Cited by 23
Elevated complement mediator levels in endothelial-derived plasma exosomes implicate endothelial innate inflammation in diminished brain function of aging humans
Elahi, F. M., Harvey, D. J., Altendahl, M., Brathaban, N., Fernandes, N. C., Casaletto, K. B., Staffaroni, A. M., Maillard, P., Hinman, J. D., Miller, B. L., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91759-2 · Cited by 27
Self-citation
Cerebrospinal Fluid EV Concentration and Size Are Altered in Alzheimer’s Disease and Dementia with Lewy Bodies
Longobardi, A., Nicsanu, R., Bellini, S., Squitti, R., Catania, M., Tiraboschi, P., Saraceno, C., Ferrari, C., Zanardini, R., Binetti, G. G., et al. (2022) · Cells · doi:10.3390/cells11030462 · Cited by 22
Circulating extracellular vesicle-containing microRNAs reveal potential pathogenesis of Alzheimer’s disease
Wang, Y., Yuan, P., Ding, L., Zhu, J., Qi, X., Zhang, Y., Li, Y., Xia, X., & Zheng, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.955511 · Cited by 23
Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer’s disease
McIntyre, J. A., Ramsey, C. J., Gitter, B. D., Saykin, A. J., Wagenknecht, D. R., Hyslop, P. A., & Initiative, F. T. A. D. N. (2015) · Autoimmunity · doi:10.3109/08916934.2015.1008464 · Cited by 22
Extracellular Vesicles as a Source of Urological Biomarkers: Lessons Learned From Advances and Challenges in Clinical Applications to Major Diseases
Choi, J., Kim, S., Kwak, H., Park, D., Park, J., Ryu, J., Park, C., & Kang, J. (2017) · International Neurourology Journal · doi:10.5213/inj.1734961.458 · Cited by 22
Plasma microRNA markers of upper limb recovery following human stroke
Edwardson, M. A., Zhong, X., Fiandaca, M. S., Federoff, H. J., Cheema, A. K., & Dromerick, A. W. (2018) · Scientific Reports · doi:10.1038/s41598-018-31020-5 · Cited by 22
Self-citation
GBA1 mutations: Prospects for exosomal biomarkers in α-synuclein pathologies
Johnson, P. H., Weinreb, N. J., Cloyd, J. C., Tuite, P., & Kartha, R. V. (2019) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2019.10.006 · Cited by 22
Prodromal Alzheimer’s Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer’s Pathology
de Vidania, S., Palomares-Pérez, I., Frank, A., Saito, T., Saido, T. C., Draffin, J. E., Szaruga, M., Chávez‐Gutiérrez, L., Calero, M., Medina, M., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.562581 · Cited by 22
Tau Secretion
Ruan, Z., & Ikezu, T. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9358-8_11 · Cited by 23
Potential Mechanisms of Tunneling Nanotube Formation and Their Role in Pathology Spread in Alzheimer’s Disease and Other Proteinopathies
Kotarba, S., Kozłowska, M., Scios, M., Saramowicz, K., Barczuk, J., Granek, Z., Siwecka, N., Wiese, W., Golberg, M., Galita, G., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910797 · Cited by 24
Exosome Cargo in Neurodegenerative Diseases: Leveraging Their Intercellular Communication Capabilities for Biomarker Discovery and Therapeutic Delivery
Zhang, S., Yang, Y., Lv, X., Zhou, X., Zhao, W., Meng, L., Zhu, S., Zhang, Z., & Wang, Y. (2024) · Brain Sciences · doi:10.3390/brainsci14111049 · Cited by 22
Neuron-derived extracellular vesicle-based diagnostics for Tau and Alzheimer’s disease
Chinnathambi, S., Kumarappan, M., Malik, S., Velmurugan, G., & Chandrashekar, M. (2025) · Brain Network Disorders · doi:10.1016/j.bnd.2024.12.006 · Cited by 21
The Role of Blood-Based Biomarkers in Transforming Alzheimer’s Disease Research and Clinical Management: A Review
Maschio, V. P. D., Roveta, F., Bonino, L., Boschi, S., Rainero, I., & Rubino, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178564 · Cited by 24
BIOFACE: A Prospective Study of Risk Factors, Cognition, and Biomarkers in a Cohort of Individuals with Early-Onset Mild Cognitive Impairment. Study Rationale and Research Protocols
Antonio, E. E., Rosende‐Roca, M., Pérez‐Cordón, A., Gil, S., Orellana, A., Cano, A. C., Alegret, M., Espinosa, A., Alarcón‐Martín, E., Valero, S., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210254 · Cited by 21
Selective Surface and Intraluminal Localization of Wnt Ligands on Small Extracellular Vesicles Released by HT-22 Hippocampal Neurons
Torres, V. I., Barrera, D. P., Varas‐Godoy, M., Arancibia, D., & Inestrosa, N. C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.735888 · Cited by 21
Nanomaterials-Based Exosomes for the Diagnostics and Drug Deliveries of Central Nervous System Diseases
Haizan, I., Park, D. H., Choi, M. Y., Lee, H.-R., & Choi, J. (2023) · BioChip Journal · doi:10.1007/s13206-023-00112-4 · Cited by 21
Blood-based CNS regionally and neuronally enriched extracellular vesicles carrying pTau217 for Alzheimer’s disease diagnosis and differential diagnosis
Guo, Z., Tian, C., Shi, Y., Song, X., Yin, W., Tao, Q., Liu, J., Peng, G.-P., Wu, Z., Wang, Y., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01727-w · Cited by 23
Research Progress on the Pathogenesis, Diagnosis, and Drug Therapy of Alzheimer’s Disease
Yang, Y., & Qiu, L. (2024) · Brain Sciences · doi:10.3390/brainsci14060590 · Cited by 22
Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer’s Disease
Rosas-Hernández, H., Cuevas, E., Raymick, J. B., Robinson, B. L., Ali, S. F., Hanig, J. P., & Sarkar, S. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190321155422 · Cited by 21
Exosome release and cargo in Down syndrome
Hamlett, E. D., LaRosa, A., Mufson, E. J., Fortea, J., Ledreux, A., & Granholm, A. (2019) · Developmental Neurobiology · doi:10.1002/dneu.22712 · Cited by 21
Circulating MicroRNAs from Serum Exosomes May Serve as a Putative Biomarker in the Diagnosis and Treatment of Patients with Focal Cortical Dysplasia
Chen, S., Pan, H.-Y., Huang, J.-B., Liu, X.-P., Li, J.-H., Ho, C.-J., Tsai, M., Yang, J., Chen, S., Chen, N.-C., et al. (2020) · Cells · doi:10.3390/cells9081867 · Cited by 21
The Potential of Liquid Biopsy of the Brain Using Blood Extracellular Vesicles: The First Step Toward Effective Neuroprotection Against Neurodegenerative Diseases
Abdel–Haq, H. (2020) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-020-00493-4 · Cited by 22
The Microfluidic Toolbox for Analyzing Exosome Biomarkers of Aging
DeCastro, J., Littig, J., Chou, P. P., Mack‐Onyeike, J., Srinivasan, A., Conboy, M. J., Conboy, I. M., & Aran, K. (2021) · Molecules · doi:10.3390/molecules26030535 · Cited by 21
Secreted Extracellular Vesicle Molecular Cargo as a Novel Liquid Biopsy Diagnostics of Central Nervous System Diseases
Monteiro-Reis, S., Carvalho-Maia, C., Bart, G., Vainio, S. J., Pedro, J., Silva, E. R., Sales, G., Henrique, R., & Jerónimo, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063267 · Cited by 21
Exosomal Aβ-Binding Proteins Identified by “In Silico” Analysis Represent Putative Blood-Derived Biomarker Candidates for Alzheimer´s Disease
Martins, T. S., Marçalo, R., Ferreira, M., Vaz, M., Silva, R. M., Rosa, I. M., Vogelgsang, J. S., Wiltfang, J., Silva, O. A. B. D. C. E., & Henriques, A. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083933 · Cited by 21
Correlation between Cognitive Impairment and Peripheral Biomarkers - Significance of Phosphorylated Tau and Amyloid-β in Alzheimer’s Disease: A New Insight
Sarkar, S., Bhui, U., Kumar, B., Ashique, S., Kumar, P., Sharma, H., Bhowmick, M., Pal, R., & Kumar, T. (2024) · Current Psychiatry Research and Reviews · doi:10.2174/0126660822329981241007105405 · Cited by 25
HIV-Associated Neurocognitive Disorder (HAND) and Alzheimer’s Disease Pathogenesis: Future Directions for Diagnosis and Treatment
Mustafa, M., Musselman, D. L., Jayaweera, D. T., Ferreira, A. D. F., Marzouka, G. R., & Dong, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011170 · Cited by 24
Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives
Kemunto, G., Ghadami, S., & Dellinger, K. (2025) · PROTEOMICS · doi:10.1002/pmic.70066 · Cited by 21
Advanced Technologies in Extracellular Vesicle Biosensing: Platforms, Standardization, and Clinical Translation
Choi, S.-J., Choi, J., Kim, J., Kim, S.-H., Cho, H.-G., Lim, M.-Y., Chae, S., Lim, K. S., Ha, S.-J., & Kim, H. (2026) · Molecules · doi:10.3390/molecules31020227 · Cited by 22
Exosomal bioactive molecules: molecular regulation, functional heterogeneity, and translational implications in disease diagnostics and therapeutics
Chigozie, V. U. (2026) · Clinical and Experimental Medicine · doi:10.1007/s10238-026-02092-9 · Cited by 24
Innovative Biomarkers for Alzheimer’s Disease: Focus on the Hidden Disease Biomarkers
Ghidoni, R., Squitti, R., Siotto, M., & Benussi, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170953 · Cited by 20
Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer’s Disease
Arastoo, M., Lofthouse, R. A., Penny, L. K., Harrington, C. R., Porter, A., Wischik, C. M., & Palliyil, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228673 · Cited by 21
Alpha-synuclein as a biomarker in Parkinson’s disease: focus on neural derived extracelluar vesicles
Agliardi, C., Guerini, F. R., Meloni, M., & Clerici, M. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.330604 · Cited by 20
Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases
Izco, M., Carlos, E., & Alvarez‐Erviti, L. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105651 · Cited by 18
Cross-Cultural Longitudinal Study on Cognitive Decline (CLoCODE) for Subjective Cognitive Decline in China and Germany: A Protocol for Study Design
Sheng, C., Yang, K. Y., He, B., Li, T., Wang, X., Du, W., Hu, X., Jiang, J., Jiang, X., Jessen, F., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215452 · Cited by 19
Exosomes in multiple sclerosis and Alzheimer's disease – Adversary and ally
Tang, N. (2023) · Biomedical Journal · doi:10.1016/j.bj.2023.100665 · Cited by 21
Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder
Burrows, K., Figueroa‐Hall, L. K., Stewart, J. L., Alarbi, A. M., Kuplicki, R., Hannafon, B. N., Tan, C., Risbrough, V. B., McKinney, B. A., Ramesh, R., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02907-x · Cited by 21
Tau Spread, Apolipoprotein E, Inflammation, and More
Gonzalez, B. L., Abud, E. M., Abud, A. M., Poon, W. W., & Gylys, K. H. (2017) · Neurologic Clinics · doi:10.1016/j.ncl.2017.01.001 · Cited by 20
Comprehensive Characterization of Nanosized Extracellular Vesicles from Central and Peripheral Organs: Implications for Preclinical and Clinical Applications
Chand, S., Jo, A., Vellichirammal, N. N., Gowen, A. M., Guda, C., Schaal, V. L., Odegaard, K. E., Lee, H., Pendyala, G., & Yelamanchili, S. V. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c01654 · Cited by 20
Altered Amyloid-β and Tau Proteins in Neural-Derived Plasma Exosomes of Type 2 Diabetes Patients with Orthostatic Hypotension
Zhang, J., Chi, H., Wang, T., Zhang, S., Shen, T., Leng, B., Sun, H., Li, Z., & Li, F. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210216 · Cited by 20
MicroRNAs in Prion Diseases—From Molecular Mechanisms to Insights in Translational Medicine
Contiliani, D. F., Ribeiro, Y. D. A., de Moraes, V. N., & Pereira, T. C. (2021) · Cells · doi:10.3390/cells10071620 · Cited by 21
Clinical implications of extracellular vesicles in neurodegenerative diseases
Vinaiphat, A., & Sze, S. K. (2019) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2019.1657407 · Cited by 20
Stress-Related Roles of Exosomes and Exosomal miRNAs in Common Neuropsychiatric Disorders
Chamakioti, M., Chrousos, G. P., Kassi, E. N., Vlachakis, D., & Yapijakis, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158256 · Cited by 19
Multicellular hypothesis for the pathogenesis of Alzheimer's disease
Goetzl, E. J., & Miller, B. L. (2017) · The FASEB Journal · doi:10.1096/fj.201601221r · Cited by 20
Self-citation
Multi-target polydiacetylene liposome-based biosensor for improved exosome detection
Kim, C., Han, B. H., Kim, D.-W., Lee, G., Hong, C., Kang, J. Y., & Lee, K. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.131286 · Cited by 19
Blood extracellular vesicles carrying brain-specific mRNAs are potential biomarkers for detecting gene expression changes in the female brain
Smirnova, L., Modafferi, S., Schlett, C., Osborne, L. M., Payne, J. L., & Sabunciyan, S. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02384-6 · Cited by 20
The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome
Granholm, A., & Hamlett, E. D. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13051338 · Cited by 23
What amyloid ligands can tell us about molecular polymorphism and disease
LeVine, H., & Walker, L. C. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.03.019 · Cited by 19
(-)-Phenserine and Inhibiting Pre-Programmed Cell Death: In Pursuit of a Novel Intervention for Alzheimer’s Disease
Becker, R. E., Greig, N. H., Lahiri, D. K., Bledsoe, J. R., Majercik, S. D., Ballard, C. G., Aarsland, D., Schneider, L. S. S., Flanagan, D. R., Govindarajan, R., et al. (2018) · Current Alzheimer Research · doi:10.2174/1567205015666180110120026 · Cited by 19
Self-citation
Blood exosomes as a tool for monitoring treatment efficacy and progression of neurodegenerative diseases
Abdel–Haq, H. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.243709 · Cited by 19
Synaptic Activity and (Neuro)Inflammation in Alzheimer’s Disease: Could Exosomes be an Additional Link?
Counil, H., & Krantic, S. M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191237 · Cited by 20
The Role of Extracellular Vesicles in the Developing Brain: Current Perspective and Promising Source of Biomarkers and Therapy for Perinatal Brain Injury
Gamage, T. K. J. B., & Fraser, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.744840 · Cited by 18
Contribution of Extracellular Vesicles and Molecular Chaperones in Age-Related Neurodegenerative Disorders of the CNS
Noori, L., Filip, K., Nazmara, Z., Mahakizadeh, S., Hassanzadeh, G., Bavisotto, C. C., Bucchieri, F., Marino, A., Cappello, F., Wnuk, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020927 · Cited by 18
The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology
Tam, S., Wear, D., Morrone, C. D., & Yu, W. H. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16108 · Cited by 20
Nanoscale flow cytometry‐based quantification of blood‐based extracellular vesicle biomarkers distinguishes MCI and Alzheimer's disease
Dayarathna, T. K., Roseborough, A. D., Gomes, J., Khazaee, R., Silveira, C. R. A., Borron, K., Yu, S., Coleman, K. K. L., Jesso, S., Finger, E. C., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14087 · Cited by 19
Neuronal insulin signaling and brain structure in nondemented older adults: the Atherosclerosis Risk in Communities Study
Walker, K. A., Chawla, S., Nogueras‐Ortiz, C. J., Coresh, J., Sharrett, A. R., Wong, D. F., Jack, C. R., Spychalla, A. J., Gottesman, R. F., & Kapogiannis, D. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.09.022 · Cited by 18
Self-citation
The oxidatively damaged DNA and amyloid-β oligomer hypothesis of Alzheimer's disease
Sanders, O. D., Rajagopal, L., & Rajagopal, J. A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.08.019 · Cited by 18
Expanding the Repertoire of Biomarkers for Alzheimer’s Disease: Targeted and Non-targeted Approaches
Galasko, D. R. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00256 · Cited by 19
Hydrogel empowered extracellular vesicles isolation, detection, and delivery
Li, Y., Liu, Z., Zheng, Z., Bai, L., Wang, W., Min, L., Hu, H., & Shi, Y. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102817 · Cited by 17
Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential
Dellar, E. R., Nikel, L., Fowler, S. L., Vahsen, B. F., Dafinca, R., Feneberg, E., Talbot, K., Turner, M. R., & Thompson, A. G. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00859-4 · Cited by 17
Biomarkers and Tools for Predicting Alzheimer's Disease in the Preclinical Stage
Li, T., Yang, Q. Z., Hu, X., & Han, Y. (2022) · Kölner Universitäts PublikationsServer (Universität zu Köln) · Cited by 17
Rational Design of Nitrogen-Doped Carbon Dots for Inhibiting β-Amyloid Aggregation
Liu, H., Guo, H., Fang, Y., Wang, L. F., & Li, P. (2023) · Molecules · doi:10.3390/molecules28031451 · Cited by 18
Tau: a biomarker of Huntington’s disease
Lepinay, E., & Cicchetti, F. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02230-9 · Cited by 19
A meta-analysis of neurogenic exosomes in the diagnosis of Alzheimer's disease
Zhang, X., Liu, H., Huang, Y., & Wang, R. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20604 · Cited by 17
Mesenchymal stem cell-derived extracellular vesicles: A novel promising neuroprotective agent for Alzheimer's disease
Chang, J., Feng, Z., Li, Y., Lv, H., Liu, S., Luo, Y., Hao, N., Zhao, L., & Liu, J. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116064 · Cited by 18
The role of exosomes derived from stem cells in nerve regeneration: A contribution to neurological repair
Zhang, Q., Liu, J., Wang, W., Lin, W., Waqas, A., Duan, W., Huang, S., Zhu, Z., & Chen, L. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114882 · Cited by 17
Dosing, collection, and quality control issues in cerebrospinal fluid research using animal models
Barten, D. M., Cadelina, G. W., & Weed, M. R. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804279-3.00004-6 · Cited by 17
The Role of Aptamer Loaded Exosome Complexes in the Neurodegenerative Diseases
Sekhon, S. S., Ahn, G., Park, G., Park, D. Y., Lee, S., Ahn, J., & Kim, Y. (2019) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-019-0392-6 · Cited by 17
Dark-Side of Exosomes
Engin, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-49844-3_4 · Cited by 18
Extracellular Vesicles in Molecular Diagnostics
Hirshman, B. R., Kras, R. T., Akers, J. C., Carter, B. S., & Chen, C. C. (2016) · Advances in clinical chemistry · doi:10.1016/bs.acc.2016.05.005 · Cited by 17
Neuron‐Derived Extracellular Vesicles: Emerging Biomarkers and Functional Mediators in Alzheimer's Disease, With Comparative Insights Into Neurodevelopment and Aging
Gonul, C. P., Karaçiçek, B., & Genç, Ş. (2025) · Developmental Neurobiology · doi:10.1002/dneu.22984 · Cited by 17
Exosomal Dynamics and Brain Redox Imbalance: Implications in Alzheimer’s Disease Pathology and Diagnosis
Bir, A., Ghosh, A., Chauhan, A., Saha, S., Saini, A. K., Bisaglia, M., & Chakrabarti, S. (2024) · Antioxidants · doi:10.3390/antiox13030316 · Cited by 18
Microfluidic Isolation of Neuronal-Enriched Extracellular Vesicles Shows Distinct and Common Neurological Proteins in Long COVID, HIV Infection and Alzheimer’s Disease
Pulliam, L., Sun, B., McCafferty, E., Soper, S. A., Witek, M. A., Hu, M., Ford, J. M., Song, S., Kapogiannis, D., Glesby, M. J., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073830 · Cited by 16
Self-citation
NIH workshop report on the trans-agency blood–brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface
Ochocinska, M. J., Zloković, B. V., Searson, P. C., Crowder, A. T., Kraig, R. P., Ljubimova, J. Y., Mainprize, T. G., Banks, W. A., Warren, R. Q., Kindzelski, A., et al. (2017) · Fluids and Barriers of the CNS · doi:10.1186/s12987-017-0061-6 · Cited by 16
Tau-Reactive Endogenous Antibodies: Origin, Functionality, and Implications for the Pathophysiology of Alzheimer’s Disease
Hromádková, L., & Ovsepian, S. V. (2019) · Journal of Immunology Research · doi:10.1155/2019/7406810 · Cited by 17
Extracellular vesicle-associated proteins as potential biomarkers
Schou, A. S., Nielsen, J. E., Askeland, A., & Jørgensen, M. M. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.02.011 · Cited by 16
Evaluation of Blood-Based Plasma Biomarkers as Potential Markers of Amyloid Burden in Preclinical Alzheimer’s Disease
Winston, C. N., Langford, O., Levin, N., Raman, R., Yarasheski, K. E., West, T., Abdel‐Latif, S., Donohue, M., Nakamura, A., Toba, K., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221118 · Cited by 16
Identification of markers for the isolation of neuron-specific extracellular vesiclesPreprint
Ter‐Ovanesyan, D., Whiteman, S. T., Gilboa, T., Kowal, E. J. K., Trieu, W., Iyer, S., Budnik, B., Babila, C. M., Heimberg, G., Burgess, M. W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.03.587267 · Cited by 16
Mesenchymal Stem Cell-Derived Extracellular Vesicles: Emerging Therapies for Neurodegenerative Diseases
Chen, P., Wang, F., Ling, B., Zhu, Y., Lin, H., Huang, J., & Wang, X.-L. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s526945 · Cited by 16
Small Extracellular Vesicles in Neurodegenerative Disease: Emerging Roles in Pathogenesis, Biomarker Discovery, and Therapy
Ghosh, M., Bayat, A., & Pearse, D. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157246 · Cited by 19
Exosomes in Age-Related Cognitive Decline: Mechanistic Insights and Improving Outcomes
Duggan, M. R., Lu, A., Foster, T. C., Wimmer, M. E., & Parikh, V. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.834775 · Cited by 15
Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma
Valle‐Tamayo, N., Pérez‐González, R., Chiva‐Blanch, G., Belbin, O., Serrano‐Requena, S., Sirisi, S., González, A. C., Giró, O., Sánchez‐Aced, É., Dols‐Icardo, O., et al. (2022) · Journal of Visualized Experiments · doi:10.3791/64107 · Cited by 19
Salivary Exosomes in Health and Disease: Future Prospects in the Eye
Liu, A., Hefley, B. S., Escandon, P., Nicholas, S. E., & Karamichos, D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076363 · Cited by 16
Exposure to environmental airborne particulate matter caused wide-ranged transcriptional changes and accelerated Alzheimer's-related pathology: A mouse study
Israel, L. L., Braubach, O., Shatalova, E. S., Chepurna, O. M., Sharma, S., Klymyshyn, D., Galstyan, A., Chiechi, A., Cox, A., Herman, D. A., et al. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106307 · Cited by 14
Extracellular vesicles mediate inflammasome signaling in the brain and heart of Alzheimer’s disease mice
Cyr, B. S., Ranaldi, E. D. L. R. M. C., Hadad, R., Dietrich, W. D., Keane, R. W., & Vaccari, J. P. D. R. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1369781 · Cited by 15
Research progress on astrocyte-derived extracellular vesicles in the pathogenesis and treatment of neurodegenerative diseases
Zhu, Y., Wang, F., Xia, Y., Wang, L., Lin, H., Zhong, T., & Wang, X. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0043 · Cited by 15
Blood biomarkers for clinical applications in Alzheimer's disease: A narrative review
Li, H., & Wang, Z. (2025) · NeuroMarkers. · doi:10.1016/j.neumar.2025.100078 · Cited by 16
Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research
Zwi‐Dantsis, L., Jayarajan, V., Church, G. M., Kamm, R. D., de Magalhães, J. P., & Moeendarbary, E. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202500217 · Cited by 16
Elevated levels of extracellular vesicles in progranulin‐deficient mice and FTD‐GRN Patients
Arrant, A. E., Davis, S. E., Vollmer, R. M., Murchison, C., Mobley, J. A., Nana, A. L., Spina, S., Grinberg, L. T., Karydas, A. M., Miller, B. L., et al. (2020) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51242 · Cited by 15
Self-citation
Photooxidation-induced fluorescence amplification system for an ultra-sensitive enzyme-linked immunosorbent assay (ELISA)
Heo, Y., Shin, K., Park, M. C., & Kang, J. Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-85107-7 · Cited by 15
Perspective: Neuroregenerative Nutrition
Steindler, D. A., & Reynolds, B. A. (2017) · Advances in Nutrition · doi:10.3945/an.117.015388 · Cited by 18
Sowing the Seeds of Discovery: Tau-Propagation Models of Alzheimer’s Disease
Bell, B. J., Malvankar, M. M., Tallon, C., & Slusher, B. S. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00531 · Cited by 15
Extracellular vesicles in patients in the acute phase of psychosis and after clinical improvement: an explorative study
Tunset, M. E., Haslene‐Hox, H., Bossche, T. V. D., Vaaler, A. E., Sulheim, E., & Kondziella, D. (2020) · PeerJ · doi:10.7717/peerj.9714 · Cited by 17

Authors: Fiandaca, M. S., Kapogiannis, D., Mapstone, M., Boxer, A., Eitan, E., Schwartz, J. B., Abner, E. L., Petersen, R. C., Federoff, H. J., Miller, B. L., & Goetzl, E. J.
Affiliations: Georgetown University Medical Center (US)
National Institute on Aging (US)
University of Rochester Medicine (US)
University of California San Francisco Medical Center (US)
University of Kentucky (US)
Mayo Clinic (US)
Corresponding author: Goetzl, Edward J.
ORCID: Fiandaca, Massimo S.
Kapogiannis, Dimitrios
Mapstone, Mark
Boxer, Adam
Eitan, Erez
Schwartz, Janice B.
Abner, Erin L.
Petersen, Ronald C.
Federoff, Howard J.
Miller, Bruce L.
Goetzl, Edward J.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2014-08-14
Volume: 11
Issue: 6
Pages: 600
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2014.06.008
PMC: PMC4329112
OpenAlex: W1995903088
Cited by: 959
References: 31
Citations by year: 2026: 77 · 2025: 91 · 2024: 109 · 2023: 86 · 2022: 115 · 2021: 106 · 2020: 105 · 2019: 93 · 2018: 46 · 2017: 50 · 2016: 50 · 2015: 24 · 2014: 3
FWCI: 28.15
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institute on Aging (NIA RO1AG030753)
National Institutes of Health (UK ADC P30 AG028383)
Genentech
Alzheimer's Association
Association for Frontotemporal Degeneration
Alzheimer's Drug Discovery Foundation
Pfizer
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: preclinical Alzheimer's disease, blood exosomes
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Peptide Fragments, Phosphorylation, Retrospective Studies, Severity of Illness Index, Time Factors, Biomarkers, Discriminant Analysis, Case-Control Studies, Amyloid beta-Peptides, tau Proteins, Exosomes, Frontotemporal Dementia, Prodromal Symptoms

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks