The DOI matches its Crossref record; 79 of the 80 references it cites were found in a registry or an index.
Down syndrome and Alzheimer's disease: Common pathways, common goals
Open accessAbstract
In the United States, estimates indicate there are between 250,000 and 400,000 individuals with Down syndrome (DS), and nearly all will develop Alzheimer's disease (AD) pathology starting in their 30s. With the current lifespan being 55 to 60 years, approximately 70% will develop dementia, and if their life expectancy continues to increase, the number of individuals developing AD will concomitantly increase. Pathogenic and mechanistic links between DS and Alzheimer's prompted the Alzheimer's Association to partner with the Linda Crnic Institute for Down Syndrome and the Global Down Syndrome Foundation at a workshop of AD and DS experts to discuss similarities and differences, challenges, and future directions for this field. The workshop articulated a set of research priorities: (1) target identification and drug development, (2) clinical and pathological staging, (3) cognitive assessment and clinical trials, and (4) partnerships and collaborations with the ultimate goal to deliver effective disease‐modifying treatments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Individuals with Down syndrome (DS), caused by trisomy of chromosome 21 (chr21, T21), are strongly predisposed to Alzheimer’s disease (AD), due to triplication of the APP gene, with ∼100% penetrance of AD brain pathology by age 40 and variable onset of dementia thereafter.”
From Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model (2025) · cites this paper as [11]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Hyperactivation of the S6K proteins correlates with increased Tau pathology and dysregulation of the insulin/IGF/mTOR signaling pathway, both in individuals with DS‐AD 55 and in idiopathic AD. 56”
From Disruption of hippocampal upstream regulators of mTOR and insulin pathways in Down syndrome with Alzheimer's disease neuropathology: Preliminary observations (2026) · cites this paper as [55]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
RETRACTED AND REPLACED: Nerve growth factor metabolic dysfunction in Down’s syndrome brains
Iulita, M. F., Carmo, S. D., Ower, A. K., Fortress, A. M., Aguilar, L. F., Hanna, M., Wısnıewskı, T., Granholm, A., Buhusi, M. C., Busciglio, J. A., et al. (2014) · Brain · doi:10.1093/brain/awt372 · Cited by 94
Self-citationRetractedInhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
Rovelet‐Lecrux, A., Hannequin, D., Raux, G., Meur, N. L., Laquerrière, A., Vital, A., Dumanchin‐Njock, C., Feuillette, S., Brice, A., Vercelletto, M., et al. (2005) · Nature Genetics · doi:10.1038/ng1718 · Cited by 1,284
Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome
Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159
Cataldo, A. M., Peterhoff, C. M., Troncoso, J. C., Gomez-Isla, T., Hyman, B. T., & Nixon, R. A. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64538-5 · Cited by 776
Self-citationAmyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease
Rumble, B. A., Retallack, R. W., Hilbich, C., Simms, G., Multhaup, G., Martins, R. N., Hockey, A., Montgomery, P., Beyreuther, K. T., & Masters, C. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198906013202203 · Cited by 656
Lemere, C. A., Blusztajn, J. K., Yamaguchi, H., Wisniewski, T., Saido, T. C., & Selkoe, D. J. (1996) · Neurobiology of Disease · doi:10.1006/nbdi.1996.0003 · Cited by 584
Self-citationA Prospective Study of Alzheimer Disease in Down Syndrome
Lai, F., & Williams, R. S. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520440031017 · Cited by 561
Salehi, A., Delcroix, J.-D., Belichenko, P. V., Zhan, K., Wu, C., Valletta, J. S., Takimoto-Kimura, R., Kleschevnikov, A. M., Sambamurti, K., Chung, P. P., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.022 · Cited by 543
Self-citationCognitive deficits and associated neurological complications in individuals with Down's syndrome
Lott, I. T., & Dierssen, M. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70112-5 · Cited by 484
Self-citation
Cited by
Sorted by citations
Items 201–293 of 293
Pieper, A. A., & Paul, B. D. (2025) · Neurotherapeutics · doi:10.1016/j.neurot.2025.e00757 · Cited by 4
Health Problems in Down Syndrome
Dey, S. (2015) · InTech eBooks · doi:10.5772/59349 · Cited by 4
Miot, S., Jeandel, C., Baghdadli, A., & Blain, H. (2018) · NPG. Neurologie, psychiatrie, gériatrie/NPG · doi:10.1016/j.npg.2018.01.004 · Cited by 4
Overk, C., Fiorini, E., Babolin, C., Vukicevic, M., Morici, C., Madani, R., Eligert, V., Kosco‐Vilbois, M. H., Roberts, A. J., Becker, A., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1202208 · Cited by 4
Self-citationDomenico, F. D., Greco, V., Tramutola, A., Rataj-Baniowska, M., Barone, E., Lanzillotta, C., Pieroni, L., Butterfield, D. A., Hérault, Y., Pagnotta, S. E., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05432-0 · Cited by 5
A comparison of dementia assessment services for people with intellectual disabilities
Gardner, E., & Slater, S. (2021) · Tizard Learning Disability Review · doi:10.1108/tldr-11-2020-0033 · Cited by 3
Clina, J. G., Danon, J. C., Helsel, B. C., Lepping, R. J., Martin, L. E., Sherman, J. R., Brucks, M. G., Donnelly, J. E., & Ptomey, L. T. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70297 · Cited by 3
Bothersome and Impactful Health Conditions in Children and Adolescents with Down Syndrome
Witt, M., Palumbo, M., & Santoro, S. L. (2025) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2025.114748 · Cited by 3
Down syndrome and Alzheimer’s disease: Same infectious cause, same preventive?
Norins, L. C. (2021) · Medical Hypotheses · doi:10.1016/j.mehy.2021.110745 · Cited by 3
Ocampo, K. E., Fernandez, Y. C., Magaña‐Ordorica, D., Angulo‐Rojo, C., Guadrón‐Llanos, A. M., Castro-Apodaca, F. J., & Magaña‐Gómez, J. A. (2022) · REVMEDUAS · doi:10.28960/revmeduas.2007-8013.v12.se.002 · Cited by 5
Sarangi, S., Minaeva, O. V., Ledoux, D. M., Parsons, D. S., Moncaster, J. A., Black, C. A., Hollander, J., Tripodis, Y., Clark, J. I., Hunter, D. G., et al. (2024) · Experimental Eye Research · doi:10.1016/j.exer.2024.109818 · Cited by 3
Ptomey, L. T., Donnelly, J. E., Burns, J. M., Morris, J. K., Hartley, S. L., Martin, L. E., Choi, I., Lee, P., Li, Y., Hunt, S. L., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70219 · Cited by 3
Anesthetic Management of a Down Syndrome Patient with Subocclusive Syndrome.
Moldoveanu, G. G., Severin, E. M., & Paun, A. (2018) · Europe PMC (PubMed Central) · doi:10.26574/maedica.2018.13.2.159 · Cited by 4
Down Syndrome and Alzheimer’s Disease: Issues and Implications for Social Work Practice
Fredericksen, J., & Fabbre, V. D. (2017) · Journal of Gerontological Social Work · doi:10.1080/01634372.2017.1393480 · Cited by 3
Diagnostic biomarkers of Alzheimer's disease in Down syndrome
Rafii, M. S. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30293-x · Cited by 3
Aging of persons with neurodevelopmental disabilities
Anker, L. A., Chick, C. F., & Hallmayer, J. F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-800136-3.00017-x · Cited by 5
Association of GLOD4 with Alzheimer’s Disease in Humans and Mice
Utyro, O., Włoczkowska, O., & Jakubowski, H. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240512 · Cited by 2
Barros‐Santos, B., Campos‐Marques, C., Salvador, A. F., & Silva, J. M. (2025) · Brain Organoid and Systems Neuroscience Journal · doi:10.1016/j.bosn.2025.04.006 · Cited by 2
Caregiver-Reported Attainment of Developmental Skills in Down Syndrome
Witt, M., Bress, J., Winickoff, J. P., & Santoro, S. L. (2026) · PEDIATRICS · doi:10.1542/peds.2024-070144 · Cited by 2
Russell, A. H., Jeffrey, D. A., Seedorf, G., Li, H., Sullivan, K. D., Potter, H., Huang, M., & Dabertrand, F. (2026) · The Journal of Physiology · doi:10.1113/jp290174 · Cited by 2
Self-citationThe role of choline in neurodevelopment
Rickman, N. C., Liu, G., Franz, A. R., Bernhard, W., & Bearer, C. F. (2026) · Pediatric Research · doi:10.1038/s41390-026-05021-4 · Cited by 2
Ringenbach, S. D. R., Holzapfel, S. D., Mulvey, G. M., & Pandya, S. (2015) · InTech eBooks · doi:10.5772/60636 · Cited by 2
Síndrome de Down y enfermedad de Alzheimer: factores de riesgo, evaluación e intervención
Pérez, E. D., Gómez, L. E., & Rodríguez, M. Á. A. (2016) · Revista Española de Discapacidad · doi:10.5569/2340-5104.04.01.02 · Cited by 2
De ziekte van Alzheimer bij mensen met het syndroom van Down
Dekker, A. D., & Deyn, P. P. D. (2018) · Neuropraxis · doi:10.1007/s12474-018-0182-y · Cited by 3
Korb, L., Sheehan, R., & Hassiotis, A. (2022) · Springer eBooks · doi:10.1007/978-3-319-95720-3_10 · Cited by 2
Meguid, N. A., Hemimi, M., Elpatrik, G., Fouad-Elhady, E. A., Dardir, A. A., & Ahmed, H. H. (2024) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-024-01206-y · Cited by 2
Practicalities (and real‐life experiences) of dementia in adults with Down syndrome
Harisinghani, A., Cottrell, C., Donelan, K., Lam, A. D., Pulsifer, M. B., & Santoro, S. L. (2024) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.32098 · Cited by 2
Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome
Saternos, H., Hamlett, E. D., Guzman, S. J., Head, E., Granholm, A., & Ledreux, A. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240043 · Cited by 2
Self-citationDaily Activities, Exercise and Endurance in Down Syndrome
Santoro, S. L., Nichols, D., Witt, M., & Oreskovic, N. M. (2025) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.64283 · Cited by 2
Overview of the Important Physical Health Concerns
Burke, E. A., O’Dwyer, M., McGlinchey, E., Foran, S., Phadraig, C. M. G., Carroll, R. E., McCallion, P., & McCarron, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-90083-4_3 · Cited by 2
Biomarkers show value of studying dementia in Down syndrome
Granholm, A., & Ledreux, A. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00558-w · Cited by 2
Self-citationFluid biomarkers for Alzheimer's disease in Down syndrome: Current status and novel trends
Iulita, M. F., Granholm, A., Carmona‐Iragui, M., Hamlett, E. D., Fortea, J., & Ledreux, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818845-3.00010-4 · Cited by 2
Self-citationCerebral vasoreactivity and intima-media thickness in Down syndrome: A case-control study
Colella, M., Stilo, C., Cocchella, A., Bianchini, D., Pilotto, A., Sette, P. D., & Musolino, R. F. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.11.013 · Cited by 2
COVID‐19 hospitalization with later long COVID in a person with Down syndrome
Amin, M. A., Khan, I. I., Nahin, S., Bonna, A. S., Afrin, S., & Hawlader, M. D. H. (2022) · Clinical Case Reports · doi:10.1002/ccr3.6425 · Cited by 1
The association of dementia risk symptoms and functional activity in adults with Down syndrome
Washington, S. E., Bodde, A. E., Helsel, B. C., Bollinger, R. M., Smith, N., Ptomey, L. T., Ances, B. M., & Stark, S. L. (2024) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70007 · Cited by 1
Wu, C., Tianshu, Z., Ke, W., Xiong, W., Zhang, Z., Zhang, S., Wang, J., Deng, L., Yan, K., Wang, M., et al. (2025) · Genomics Proteomics & Bioinformatics · doi:10.1093/gpbjnl/qzaf054 · Cited by 1
Wagemann, O., Tesky, V. A., Schall, A., Nübling, G., Wlasich, E., Hüer, T., Walendzik, A., Weitzel, M., Giebel, G. D., Raszke, P., et al. (2025) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-2708-3648 · Cited by 1
Development and Validation of a Health Measure for Down Syndrome.
Santoro, S. L., Campbell, A., Cabrera, M., Co, J. P. T., Donelan, K., Haugen, K., Krell, K., Shaffer, M., Skotko, B., Winickoff, J. P., et al. (2025) · Jornal de Pediatria · doi:10.1016/j.jpeds.2025.114888 · Cited by 3
Caregivers' Perspectives on Medical Management and Its Helpfulness in Down Syndrome
Krell, K., Witt, M., & Santoro, S. L. (2025) · American Journal of Medical Genetics Part A · doi:10.1002/ajmga.70006 · Cited by 1
The impact of congenital heart disease on the timing of Alzheimer's disease in Down syndrome
Clina, J. G., Helsel, B. C., Hartley, S. L., White, D. A., Fleming, V., Handen, B. L., Christian, B. T., Head, E., Mapstone, M., Hom, C. L., et al. (2026) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.70257 · Cited by 1
Self-citationNeurological complications associated with Down syndrome
Murugesan, L., Cithambaram, S. P., Gunasekaran, A., Abidharini, J. D., Philomenathan, A. P. J., & Arumugam, V. A. (2026) · Brain Science and Child Development · doi:10.1016/j.bscd.2026.100008 · Cited by 1
What We Should Not Forget about Down Syndrome
Fragoso, D. C., Nunes, D. M., Maia, A. C. M., Garcia, L. A. L., Alves, H. C. B. R., da Silva, C. J., & Leite, C. C. (2021) · Neurographics · doi:10.3174/ng.2000043 · Cited by 2
Síndrome de Down como fator de risco genético para a Doença de Alzheimer
Valente, T. J. M. B. D. S., Dantas, J. M. D. S., Vieira, H. E. E., & Martins, A. E. S. (2022) · Anais da Faculdade de Medicina de Olinda · doi:10.56102/afmo.2022.209 · Cited by 1
Down Syndrome—Basque Alzheimer Initiative (DS-BAI): Clinic-Biological Cohort
Altuna, M., Estanga, A., Garrido, A., Saldias, J., Cañada, M., Echeverria, M., Larrea, J. Á., Ayo, P., Fiz, A., Muñoz, M., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13041139 · Cited by 1
Howard, E., Initiative, A. D. N., Moody, J. N., Prieto, S., & Hayes, J. P. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240254 · Cited by 2
A Case Study of Aging and Intellectual and Developmental Disability Collaboration in Ohio
Heston-Mullins, J., Primetica, B., Bibbo, J. L., Bollin, S., Wyrostek, L., Barrett, D., Williman, M., Burman, B., Haas, A., Scharf, L., et al. (2025) · The Gerontologist · doi:10.1093/geront/gnaf137 · Cited by 1
Management of Dementia in Intellectual Disability
Prasher, V. P., & Mahmood, H. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108617444.011 · Cited by 1
Treadmill exercise and neuroinflammation
Real, C. C., Binda, K. H., & Landau, A. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817990-1.00034-2 · Cited by 1
Gomes, F. D. C., Santos, I. B. F., Stephani, C. M., Ferrari, M. D. F. R., Galvis‐Alonso, O. Y., Goloni‐Bertollo, E. M., Neto, J. S. D. M., & Pavarino, É. C. (2022) · Tissue and Cell · doi:10.1016/j.tice.2022.101898 · Cited by 1
McCarron, M., Kelly, K., McCallion, P., Burke, E. A., Haigh, M., & Wormald, A. (2022) · Springer eBooks · doi:10.1007/978-3-030-98697-1_9 · Cited by 1
Genetic Counseling: Preconception, Prenatal, and Perinatal
Milunsky, A., & Milunsky, J. M. (2021) · Wiley eBooks · doi:10.1002/9781119676980.ch1 · Cited by 1
Nordbeck, A. J., Martá‐Ariza, M., Ek Olofsson, H., Kanshin, E., Ueberheide, B., Jones, K., Sanford, B., Hamlett, E. D., Head, E., Mufson, E. J., et al. (2026) · Alzheimer's & Dementia · doi:10.1002/alz.71776
“38 Hyperactivation of the S6K proteins correlates with increased Tau pathology and dysregulation of the insulin/IGF/mTOR signaling pathway, both in individuals with DS-AD 55 and in idiopathic AD.”
Self-citationRamasamy, P., Gupta, D. P., Paramaswamy, R., & Lakshmi, R. (2019) · International Journal of Medical Anesthesiology · doi:10.33545/26643766.2019.v2.i2b.31
Turner syndrome associated with cerebellar abnormalities
Kitova, T. T., Uchikova, E. H., Kilova, K. P., & Belovejdov, V. (2020) · Journal of Anatomical Society of India · doi:10.4103/jasi.jasi_50_19
Cuidados de enfermagem em pacientes portadores de Alzheimer associado à síndrome de Down
Sugawara, A. M., de Melo, S. F., da Silva, A. D., Luiz, E. D. F. C., & Lima, J. C. S. (2021) · Revista Brasileira de Ciências Biomédicas · doi:10.46675/rbcbm.v1i3.38
CSF Biomarkers in Down Syndrome and Autosomal Dominant Alzheimer DiseasePreprint
Fagan, A. M., Henson, R. L., Li, Y., Boerwinkle, A. H., Xiong, C., Bateman, R. J., Goate, A., Ances, B. M., Doran, E. W., Christian, B. T., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3746265
Self-citationCorrelating MRI-Based Brain Volumetry and Cognitive Assessment in Down Syndrome PatientsPreprint
Hamadelseed, O., & Skutella, T. (2021) · Research Square · doi:10.21203/rs.3.rs-1125604/v1
Zampar, S. (2021) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9004
Amin, M. A., Khan, I. I., Nahin, S., Bonna, A. S., Afrin, S., Das, S. P., & Hawlader, M. D. H. (2022) · doi:10.22541/au.164791948.84586726/v1
Correlating MRI-Based Brain Volumetry and Cognitive Assessment in Down Syndrome PatientsPreprint
Hamadelseed, O., & Skutella, T. (2022) · Research Square · doi:10.21203/rs.3.rs-1125604/v2
Alzheimer disease and neuroinflammation in Down syndrome
Ganguly, B. B. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90456-8.00014-4
Dementia in people with Down syndrome
Lewis, F., Hinson-Raven, M., Saraswat, C., Cruden-Smith, L., Blunstone, R., & Bonnici-Mallia, A. M. (2023) · InnovAiT Education and inspiration for general practice · doi:10.1177/17557380231153674
Screening and functional validations of APP, PSEN1 and PSEN2 mutations from PUMCH dementia cohortPreprint
Li, J., Dong, L., Sha, L., Liu, C., Mao, C., Huang, X., Wang, J., Shang, L., Chu, S., Jin, W., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2622824/v1
Lifestyle modifications and nutrition in Alzheimer's disease
Bhatti, G. K., Mishra, J., Sehrawat, A., Sharma, E., Kanozia, R., Navik, U., Reddy, P. H., & Bhatti, J. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89834-8.00049-0
Investigating Brain Alterations in the Dp1Tyb Mouse Model of Down SyndromePreprint
Navacerrada, M. E. S., Kim, E., Siow, B. M., Ma, D., Gonzalez, L. R., Simmons, C., Hayward, D., Gibbins, D., Singh, N., Strydom, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.26.550698
Reyers, F., & D’Cruz, D. (2023) · FPID Bulletin The Bulletin of the Faculty for People with Intellectual Disabilities · doi:10.53841/bpsfpid.2023.21.2.33
Biomarcadores amiloidogênicos na síndrome de Down
Bram, J. M. D. F. (2023) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2023.tde-20092023-163847
León-Paz-de-Rodríguez, G. E., Rodríguez-León, E., & Iñiguez-Palomares, R. A. (2024) · ACS Omega · doi:10.1021/acsomega.3c07379
Vaiasicca, S., Melone, G., James, D. W., Quintela, M., Preziuso, A., Finnell, R. H., Conlan, R. S., Francis, L. W., & Corradetti, B. (2023) · Figshare · doi:10.6084/m9.figshare.24186068
Vaiasicca, S., Melone, G., James, D. W., Quintela, M., Preziuso, A., Finnell, R. H., Conlan, R. S., Francis, L. W., & Corradetti, B. (2023) · Figshare · doi:10.6084/m9.figshare.24186062
Vaiasicca, S., Melone, G., James, D. W., Quintela, M., Preziuso, A., Finnell, R. H., Conlan, R. S., Francis, L. W., & Corradetti, B. (2023) · Figshare · doi:10.6084/m9.figshare.24186065
Vaiasicca, S., Melone, G., James, D. W., Quintela, M., Preziuso, A., Finnell, R. H., Conlan, R. S., Francis, L. W., & Corradetti, B. (2023) · Figshare · doi:10.6084/m9.figshare.24186056
Exploring the complex nexus of Alzheimer’s disease in down syndrome
Li, Y. (2024) · Theoretical and Natural Science · doi:10.54254/2753-8818/44/20240409
Aging and dementia in Down syndrome
Ali, S., Pelt, K. L. V., Head, E., Harp, J. P., Glueck, A. C., & Schmitt, F. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19041-4.00037-6
Polyamine biosynthesis dysregulation in Alzheimer’s disease and Down syndrome cellular modelsPreprint
Sola, A., Sandberg, A., Pham, C., Revier, A., Hebinck, M., Penney, A. L., Caviedes, P. A., Kumar, S., Granholm, A., Linseman, D. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.31.635912
Self-citationA review of clinical trials in Down Syndrome
Denne, E., Channell, M. M., White, N., Fidler, D., Baumer, N., Wu, J., Tapia, I. E., Froehlich, T. E., Hartley, S. L., & Esbensen, A. J. (2025) · International review of research in developmental disabilities · doi:10.1016/bs.irrdd.2025.09.002
Toman, M., Atanasio, M., & Teaster, P. B. (2025) · Healthcare · doi:10.3390/healthcare13222925
Vaiasicca, S., Melone, G., James, D. W., Quintela, M., Preziuso, A., Finnell, R. H., Conlan, R. S., Francis, L. W., & Corradetti, B. (2023) · Figshare · doi:10.6084/m9.figshare.24186074
Vaiasicca, S., Melone, G., James, D. W., Quintela, M., Preziuso, A., Finnell, R. H., Conlan, R. S., Francis, L. W., & Corradetti, B. (2023) · Figshare · doi:10.6084/m9.figshare.24186050
Lemoine, L., Ledreux, A., Mufson, E. J., Perez, S. E., Simic, G., Doran, E. W., Lott, I. T., Carroll, S., Bharani, K., Thomas, S., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13272076
Self-citationVaiasicca, S., Melone, G., James, D. W., Quintela, M., Preziuso, A., Finnell, R. H., Conlan, R. S., Francis, L. W., & Corradetti, B. (2023) · Figshare · doi:10.6084/m9.figshare.24186053
Węgiel, J., Flory, M. J., Kuchna, I., Nowicki, K., Wegiel, J., Ma, S. Y., Zhong, N., Wierzba‐Bobrowicz, T., de Leon, M., Lai, F., et al. (2022) · Figshare · doi:10.6084/m9.figshare.17870374
Self-citationVaiasicca, S., Melone, G., James, D. W., Quintela, M., Preziuso, A., Finnell, R. H., Conlan, R. S., Francis, L. W., & Corradetti, B. (2023) · Figshare · doi:10.6084/m9.figshare.24186059
Vaiasicca, S., Melone, G., James, D. W., Quintela, M., Preziuso, A., Finnell, R. H., Conlan, R. S., Francis, L. W., & Corradetti, B. (2023) · Figshare · doi:10.6084/m9.figshare.24186071
Takenoshita, S., Terada, S., Inoue, T., Kurozumi, T., Takaki, M., Kuwano, R., & Suemitsu, S. (2025) · Journal of Intellectual Disability Research · doi:10.1111/jir.70075
Recupero, M., Zagaria, T., Elia, F., Grasso, M., Caraci, F., Barone, C., Greco, D., Ferri, R., Serretti, A., & Buono, S. (2026) · L Encéphale · doi:10.1016/j.encep.2025.10.009
Novel PSEN1 ( Q223 L ) mutation causes early-onset Alzheimer’s disease: A case report
Li, J., Zhou, F.-L., Chen, J.-J., Lin, Z.-J., Shi, X., Zhang, G.-G., Yang, H.-J., Dong, M., Yi, L., Hu, J., et al. (2026) · World Journal of Radiology · doi:10.4329/wjr.116652
Witt, M., Zeng, C., & Santoro, S. L. (2026) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.70219
Multiomics and proteomic insights into Alzheimer’s disease biology in Down syndrome
Martá-Ariza, M., & Wisniewski, T. R. (2026) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2026.2695187
Self-citationEspina, M. G., Becerra-Quinteros, A., Hermosilla-Navea, C., Orellana-Rubilar, J., López-Véliz, X., & Flores-Carrasco, S. V. (2026) · Aging & Mental Health · doi:10.1080/13607863.2026.2733920
Acton, D., Kumar, M., & Jaydeokar, S. (2026) · British Journal of Learning Disabilities · doi:10.1111/bld.70082
Metadata
- Authors
- Hartley, D., Blumenthal, T., Carrillo, M., DiPaolo, G., Esralew, L., Gardiner, K., Granholm, A.-C., Iqbal, K., Krams, M., Lemere, C., Lott, I., Mobley, W., Ness, S., Nixon, R., Potter, H., Reeves, R., Sabbagh, M., Silverman, W., Tycko, B., Whitten, M., & Wisniewski, T.
- Affiliations
- Alzheimer's Association (US)
- University of Colorado Boulder (US)
- Medical and Scientific Relations Alzheimer's Association Chicago IL USA
- Department of Pathology and Cell Biology Columbia University Medical Center and The Taub Institute for Research on Alzheimer's Disease and The Aging Brain New York NY USA
- Trinitas Regional Medical Center (US)
- University of Colorado Anschutz (US)
- Medical University of South Carolina (US)
- Department of Neurochemistry New York State Institute for Basic Research in Developmental Disabilities New York NY USA
- Janssen Research & Development (United States) (US)
- Brigham and Women's Hospital (US)
- University of California, Irvine (US)
- University of California San Diego (US)
- NYU Langone Health (US)
- Johns Hopkins University (US)
- Banner Health (US)
- Kennedy Krieger Institute (US)
- Columbia University Irving Medical Center (US)
- Global Down Syndrome Foundation (US)
- Department of Neurology, Pathology, and Psychiatry New York University, Langone Medical Center New York NY USA
- Corresponding author
- Hartley, Dean
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2014-12-12
- Volume
- 11
- Issue
- 6
- Pages
- 700-709
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC4817997
- OpenAlex
- W1991023630
- Cited by
- 290
- References
- 80
- Citations by year
- 2026: 12 · 2025: 26 · 2024: 24 · 2023: 33 · 2022: 27 · 2021: 46 · 2020: 27 · 2019: 26 · 2018: 15 · 2017: 19 · 2016: 20 · 2015: 13 · 2014: 2
- FWCI
- 17.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (R01AG012122, R01AG037942)
- National Institute of Neurological Disorders and Stroke (R01NS076291)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Down syndrome, Alzheimer's disease
- MeSH terms
- Alzheimer Disease, Animals, Clinical Trials as Topic, Congresses as Topic, Disease Models, Animal, Down Syndrome, Humans, Neuropsychological Tests, Drug Discovery
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
