Mobley, William C.

Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair

Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience

Nerve injury and regenerationNeurogenesis and neuroplasticity mechanisms

Cited by 1,284

Increased App expression in a mouse model of Down’s syndrome disrupts NGF transport and causes cholinergic neuron degeneration

Salehi, A., Delcroix, J.-D., Belichenko, P. V., Zhan, K., Wu, C., Valletta, J. S., Takimoto-Kimura, R., Kleschevnikov, A. M., Sambamurti, K., Chung, P. P., et al. (2006) · Neuron

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 543

Enabling Technologies for Personalized and Precision Medicine

Ho, D., Quake, S. R., McCabe, E. R. B., Chng, W. J., Chow, E. K., Ding, X., Gelb, B. D., Ginsburg, G. S., Hassenstab, J., Ho, C.-M., et al. (2020) · Trends in Biotechnology

Technology and Human Factors in Education and HealthAdvanced Biosensing Techniques and Applications

Cited by 517

Reversing a model of Parkinson's disease with in situ converted nigral neurons

Qian, H., Kang, X., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang, X., Xue, Y., Maimon, R., Dowdy, S. F., et al. (2020) · Nature

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 480

Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome

Kleschevnikov, A. M., Belichenko, P. V., Villar, A. J., Epstein, C. J., Malenka, R. C., & Mobley, W. C. (2004) · The Journal of Neuroscience

Down syndrome and intellectual disability researchNeuroscience and Neuropharmacology Research

Cited by 459

Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

Holtzman, D. M., Santucci, D., Kilbridge, J., Chua-Couzens, J., Fontana, D. J., Daniels, S. E., Johnson, R. M., Chen, K., Sun, Y., Carlson, E., et al. (1996) · Proceedings of the National Academy of Sciences

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 448

Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities

Sago, H., Carlson, E. J., Smith, D. J., Kilbridge, J., Rubin, E. M., Mobley, W. C., Epstein, C. J., & Huang, T.-T. (1998) · Proceedings of the National Academy of Sciences

Down syndrome and intellectual disability researchGenetics and Neurodevelopmental Disorders

Cited by 382

Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion

Cooper, J. D., Salehi, A., Delcroix, J.-D., Howe, C. L., Belichenko, P. V., Chua-Couzens, J., Kilbridge, J. F., Carlson, E. J., Epstein, C. J., & Mobley, W. C. (2001) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 336

Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome

Belichenko, P. V., Masliah, E., Kleschevnikov, A. M., Villar, A. J., Epstein, C. J., Salehi, A., & Mobley, W. C. (2004) · Journal of Comparative Neurology

Down syndrome and intellectual disability researchNeuroscience and Neuropharmacology Research

Cited by 297

Down syndrome and Alzheimer's disease: common pathways, common goals

Hartley, D., Blumenthal, T., Carrillo, M., DiPaolo, G., Esralew, L., Gardiner, K., Granholm, A.-C., Iqbal, K., Krams, M., Lemere, C., et al. (2015) · Alzheimer's & Dementia

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 290

Widespread changes in dendritic and axonal morphology in Mecp2‐mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

Belichenko, P. V., Wright, E. E., Belichenko, N. P., Masliah, E., Li, H. H., Mobley, W. C., & Francke, U. (2009) · Journal of Comparative Neurology

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 272

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of down syndrome.

Belichenko, P. V., Kleschevnikov, A. M., Masliah, E., Wu, C., Takimoto‐Kimura, R., Salehi, A., & Mobley, W. C. (2009) · Journal of Comparative Neurology

Down syndrome and intellectual disability researchNeuroscience and Neuropharmacology Research

Cited by 141

Traffic at the intersection of neurotrophic factor signaling and neurodegeneration

Salehi, A., Delcroix, J.-D., & Mobley, W. C. (2003) · Trends in Neurosciences

Nerve injury and regenerationHereditary Neurological Disorders

Cited by 131

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice

Yu, T., Liu, C., Belichenko, P., Clapcote, S. J., Li, S., Pao, A., Kleschevnikov, A., Bechard, A. R., Asrar, S., Chen, R., et al. (2010) · Brain Research

Down syndrome and intellectual disability researchGenetics and Neurodevelopmental Disorders

Cited by 127

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

Kleschevnikov, A. M., Belichenko, P. V., Gall, J., George, L., Nosheny, R., Maloney, M. T., Salehi, A., & Mobley, W. C. (2012) · Neurobiology of Disease

Down syndrome and intellectual disability researchNeuroscience and Neuropharmacology Research

Cited by 124

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (−/−) mice but impaired clearance of axonal degeneration products following injury

Fagan, A. M., Murphy, B. A., Patel, S. N., Kilbridge, J. F., Mobley, W. C., Bu, G., & Holtzman, D. M. (1998) · Experimental Neurology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 116

Further understanding the connection between Alzheimer's disease and Down syndrome

Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., et al. (2020) · Alzheimer's & Dementia

Down syndrome and intellectual disability researchDementia and Cognitive Impairment Research

Cited by 105

Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Zhao, Y., Tseng, I.-C., Heyser, C. J., Rockenstein, E., Mante, M., Adame, A., Zheng, Q., Huang, T., Wang, X., Arslan, P. E., et al. (2015) · Neuron

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 98

Genetic dissection of the down syndrome critical region

Jiang, X., Liu, C., Yu, T., Zhang, L., Meng, K., Xing, Z., Belichenko, P. V., Kleschevnikov, A. M., Pao, A., Peresie, J., et al. (2015) · Human Molecular Genetics

Down syndrome and intellectual disability researchGenetics and Neurodevelopmental Disorders

Cited by 88

Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention

Rynearson, K. D., Ponnusamy, M., Prikhodko, O., Xie, Y., Zhang, C., Nguyen, P., Hug, B., Sawa, M., Becker, A., Spencer, B., et al. (2021) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative Diseases

Cited by 76

Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model

Sawa, M., Overk, C., Becker, A., Derse, D., Albay, R., Weldy, K., Salehi, A., Beach, T. G., Doran, E., Head, E., et al. (2022) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 54

Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial

Rafii, M. S., Sol, O., Mobley, W. C., Delpretti, S., Skotko, B. G., Burke, A. D., Sabbagh, M. N., Yuan, S. H., Rissman, R. A., Pulsifer, M., et al. (2022) · JAMA Neurology

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 52

Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain

Fu, X.-D., & Mobley, W. C. (2023) · Annual Review of Neuroscience

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 16